Obesity
|
0.700 |
Biomarker
|
disease |
BEFREE |
In addition, SH2B1 is an obesity-related gene, and epidemiological surveys suggest a complex relationship between obesity and cancer.
|
31739166 |
2020 |
Obesity
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
While the majority of these were located in intergenic regions or in a locus on chromosome 16 near and in the NPIPL1 and SH2B1 genes (best SNP: rs4788101, p = 2.1E-24), five were located in the ETV5 gene (best SNP: rs1516725, p = 1E-24), which was previously associated with both BD and obesity, and one in the RPGRIP1L gene (rs1477199, p = 5.7E-09), which was also included in the Signaling by Hedgehog pathway.
|
31754094 |
2019 |
Obesity
|
0.700 |
Biomarker
|
disease |
BEFREE |
An understanding of this expanded peptide recognition will allow for the identification of novel physiologically relevant SH2B1/peptide interactions, which can contribute to the design of obesity and diabetes pharmaceuticals to target the ligand-binding interface of SH2B1 with high specificity.
|
29127727 |
2018 |
Obesity
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Of these, 4% (3/67) had 16p11.2 microdeletions encompassing the known obesity risk gene SH2B1.
|
29976977 |
2018 |
Obesity
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
A 200∼240 kb SH2B1-containing deletion region on 16p11.2 is associated with early-onset obesity and developmental delay.
|
28544142 |
2017 |
Obesity
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Variants in APOBR contributed as strongly as variants in SH2B1 to the association with extreme obesity in the chromosomal region chr16p11.2.
|
25955518 |
2015 |
Obesity
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Obesity-related genetic variants, including TMEM18 (rs6548238), SH2B1 (rs7498665), and GNPDA2 (rs10938397), have been shown to be associated with obesity in the general population.
|
26263223 |
2015 |
Obesity
|
0.700 |
Biomarker
|
disease |
BEFREE |
Animal studies, genome-wide association and genomic structural variation studies have identified the SH2B1 gene as a candidate gene for obesity.
|
26031769 |
2015 |
Obesity
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
In the meta-analysis of 42 studies for 11 obesity/BMI-associated loci, we observed a statistically significant association of the FTO rs9939609 polymorphism (66 425 T2D cases/239 689 normoglycaemic subjects; P = 1·00 × 10(-41) ) and six other variants with T2D risk (17 915 T2D cases/27 531 normoglycaemic individuals: n = 40 629-130 001; all P < 0·001 for SH2B1 rs7498665, FAIM2 rs7138803, TMEM18 rs7561317, GNPDA2 rs10938397, BDNF rs925946 and NEGR1 rs2568958).
|
24528214 |
2014 |
Obesity
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Inversion alleles strongly correlate with expression levels of neighboring genes, especially TUFM (p = 3.0 × 10(-40)) that encodes a mitochondrial protein regulator of energy balance and inhibitor of type 1 interferon, and other candidates for asthma (IL27) and obesity (APOB48R and SH2B1).
|
24560518 |
2014 |
Obesity
|
0.700 |
Biomarker
|
disease |
BEFREE |
This study highlighted the importance of above two candidate genes (SH2B1 and FAIM2) in the risk of overweight/obesity.
|
24621099 |
2014 |
Obesity
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Here, we identify 4 additional SH2B1 variants by sequencing 500 individuals with severe early-onset obesity.
|
24971614 |
2014 |
Obesity
|
0.700 |
Biomarker
|
disease |
BEFREE |
In addition, SH2B1 was associated only with class I/II obesity and MC4R only with class III obesity.
|
23950976 |
2013 |
Obesity
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Sanger sequencing of PCR products of all FTO and SH2B1 exons and their flanking regions were performed in 338 Chinese Han children with obesity and 221 age- and sex-matched lean controls.
|
23825611 |
2013 |
Obesity
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The nominal associations of rs925946 and rs7498665 obesity risk variants near the BDNF and SH2B1 genes with increased snacking deserve further investigation.
|
23640704 |
2013 |
Obesity
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The mean systolic blood pressure was lowered and concentrations of HDL-cholesterol increased significantly.The obesity risk alleles of non-synonymous SNPs at SH2B1 and APOB48R have no strong effect on weight loss-related phenotypes in overweight children after a 1-year lifestyle intervention.
|
23519644 |
2013 |
Obesity
|
0.700 |
Biomarker
|
disease |
BEFREE |
Thus, the role of SH2B1 in both obesity and insulin resistance makes it a strong candidate for T2D.
|
24103803 |
2013 |
Obesity
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Of five studied variants, only two (SEC16B rs10913469, SH2B1 rs4788102) were nominally associated with indices of adiposity and obesity risk in girls and only SEC16B rs10913469 in children at puberty (p < 0·05), while no statistical associations was found for three other variants (PCSK1rs6235, KCTD15 rs29941, BAT2 rs2844479).
|
23121087 |
2013 |
Obesity
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
We genotyped obesity risk single nucleotide polymorphisms (SNPs) derived from genome-wide association studies in or in proximity to the following genes: NEGR1, TNKS, SDCCAG8, FTO, MC4R, TMEM18, PTER, MTCH2, SH2B1, MAF, NPC1, and KCTD15.
|
23843577 |
2013 |
Obesity
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
We identified SH2B1 loss-of-function mutations in a large cohort of patients with severe early-onset obesity.
|
23160192 |
2012 |
Obesity
|
0.700 |
Biomarker
|
disease |
BEFREE |
The SH2B1 gene (Src-homology 2B adaptor protein 1 gene) is a solid candidate gene for obesity.
|
23270367 |
2012 |
Obesity
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Six other SNPs, rs2815752 (NEGR1), rs10938397 (GNPDA2), rs10838738 (MTCH2), rs7498665 (SH2B1), rs17782313 (MC4R) and rs11084753 (KCTD15), were not associated with obesity (P>0.05).
|
22083549 |
2012 |
Obesity
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Recurrent deletions in this region encompassing the SH2B1 gene were recently reported in early-onset obesity and in individuals with neurodevelopmental disorders associated with phenotypic variability.
|
22234155 |
2012 |
Obesity
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
With the current study we were able to replicate and confirm that the SH2B1 gene locus is significantly associated with complex obesity in a Caucasian population.
|
22248999 |
2011 |
Obesity
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
These data support the original finding that there is an association between measures of obesity and a variant near the MC4R gene and extends these results to a younger population and implicates FTO, TMEM18, and SH2B1 polymorphisms in subcutaneous fat regulation.
|
20725061 |
2011 |