|
Colorectal Carcinoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Western blot and wound scratch analyses were used to determine the signaling pathway for KRT23-mediated activation of CRC growth and migration.
|
28749462 |
2017 |
|
Neoplasms
|
0.020 |
Biomarker
|
group |
BEFREE |
By contrast, KRT23 inhibition significantly inhibited tumor cell growth in vitro and in vivo.
|
28749462 |
2017 |
|
Malignant tumor of colon
|
0.020 |
Biomarker
|
disease |
BEFREE |
Knockdown of KRT23 rendered colon cancer cells more sensitive to irradiation and reduced proliferation of the KRT23 depleted cells compared to irradiated control cells.
|
24039993 |
2013 |
|
Colorectal Carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Silencing the most highly upregulated genes, CDH3, CLDN1, KRT23, and MMP7, in adenoma and CRC cell lines resulted in a significant decrease in viability (P < 0.0001) and proliferation (P < 0.0001) as compared to controls and an increase in cellular apoptosis (P < 0.05 for CDH3, KRT23).
|
23682078 |
2013 |
|
Neoplasms
|
0.020 |
AlteredExpression
|
group |
BEFREE |
Promoter methylation correlated with absent expression, while increased KRT23 expression in tumor samples correlated with promoter hypomethylation, as confirmed by bisulfite sequencing.
|
24039993 |
2013 |
|
Malignant tumor of colon
|
0.020 |
Biomarker
|
disease |
BEFREE |
Phosphoprotein Keratin 23 accumulates in MSS but not MSI colon cancers in vivo and impacts viability and proliferation in vitro.
|
19383294 |
2007 |
|
Hepatitis A
|
0.010 |
Biomarker
|
disease |
BEFREE |
Identification of Keratin 23 as a Hepatitis C Virus-Induced Host Factor in the Human Liver.
|
31216713 |
2019 |
|
Hepatitis C
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Ectopic expression of KRT23 enhanced HCV infection; however, CRIPSPR/Cas9-mediated knockout did not show altered replication efficiency.
|
31216713 |
2019 |
|
Liver diseases
|
0.010 |
AlteredExpression
|
group |
BEFREE |
For example, keratin 23 (KRT23) was reported as a stress-inducible protein, whose expression levels correlate with the severity of liver disease.
|
31216713 |
2019 |
|
Adult Liver Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Conclusion: These results revealed that MYC-mediated transcriptional potentiation of select PPARA target genes, such as Krt23, may remove rate-limiting constraints on hepatocyte growth and proliferation leading to liver cancer.
|
30697791 |
2019 |
|
Liver and Intrahepatic Biliary Tract Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Conclusion: These results revealed that MYC-mediated transcriptional potentiation of select PPARA target genes, such as Krt23, may remove rate-limiting constraints on hepatocyte growth and proliferation leading to liver cancer.
|
30697791 |
2019 |
|
Malignant neoplasm of liver
|
0.010 |
Biomarker
|
disease |
BEFREE |
Conclusion: These results revealed that MYC-mediated transcriptional potentiation of select PPARA target genes, such as Krt23, may remove rate-limiting constraints on hepatocyte growth and proliferation leading to liver cancer.
|
30697791 |
2019 |
|
Hepatitis C, Chronic
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In this study, we investigated KRT23 mRNA levels in datasets from liver biopsies of chronic hepatitis C (CHC) patients and in primary human hepatocytes experimentally infected with HCV, in addition to hepatoma cells.
|
31216713 |
2019 |
|
Liver carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Finally, KRT23 protein is highly elevated in human HCCs.
|
30697791 |
2019 |
|
Malignant Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
KRT23 promoted cancer stem cell properties and increased the expression of CD133 and CD44.
|
28749462 |
2017 |
|
Malignant neoplasm of stomach
|
0.010 |
Biomarker
|
disease |
BEFREE |
We found that GCs with different Lauren classifications had different molecular characteristics and identified FRZB, EFEMP1, and KRT23 as subtype-specific prognostic factors for GC patients.
|
28013168 |
2017 |
|
Stomach Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
We found that GCs with different Lauren classifications had different molecular characteristics and identified FRZB, EFEMP1, and KRT23 as subtype-specific prognostic factors for GC patients.
|
28013168 |
2017 |
|
Primary malignant neoplasm
|
0.010 |
Biomarker
|
group |
BEFREE |
KRT23 promoted cancer stem cell properties and increased the expression of CD133 and CD44.
|
28749462 |
2017 |
|
Malignant neoplasm of colon and/or rectum
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Keratin 23 promotes telomerase reverse transcriptase expression and human colorectal cancer growth.
|
28749462 |
2017 |
|
Adenocarcinoma
|
0.010 |
PosttranslationalModification
|
group |
BEFREE |
Array based methylation profiling of 40 colon samples showed that the promoter of KRT23 was methylated in normal colon mucosa, while hypomethylated in most adenocarcinomas.
|
24039993 |
2013 |
|
Colon Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Knockdown of KRT23 rendered colon cancer cells more sensitive to irradiation and reduced proliferation of the KRT23 depleted cells compared to irradiated control cells.
|
24039993 |
2013 |
|
Steatohepatitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
We propose that KRT23 and AKR1B10 may serve as future potential biomarkers for steatohepatitis as well as markers for progression to HCC.
|
23071592 |
2012 |
|
Acute periodontitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Association evaluation by Fisher's exact test (p < 0.01) revealed statistically significant SNPs in multiple genes, not only in inflammatory mediators (IL6ST and PTGDS, associated with aggressive periodontitis; and CTSD, associated with severe chronic periodontitis), but also in structural factors of periodontal tissues (COL4A1, COL1A1, and KRT23, associated with aggressive periodontitis; and HSPG2, COL17A1, and EGF, associated with severe chronic periodontitis).
|
15081423 |
2004 |
|
Aggressive Periodontitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Association evaluation by Fisher's exact test (p < 0.01) revealed statistically significant SNPs in multiple genes, not only in inflammatory mediators (IL6ST and PTGDS, associated with aggressive periodontitis; and CTSD, associated with severe chronic periodontitis), but also in structural factors of periodontal tissues (COL4A1, COL1A1, and KRT23, associated with aggressive periodontitis; and HSPG2, COL17A1, and EGF, associated with severe chronic periodontitis).
|
15081423 |
2004 |
|
Chronic Periodontitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Association evaluation by Fisher's exact test (p < 0.01) revealed statistically significant SNPs in multiple genes, not only in inflammatory mediators (IL6ST and PTGDS, associated with aggressive periodontitis; and CTSD, associated with severe chronic periodontitis), but also in structural factors of periodontal tissues (COL4A1, COL1A1, and KRT23, associated with aggressive periodontitis; and HSPG2, COL17A1, and EGF, associated with severe chronic periodontitis).
|
15081423 |
2004 |