IBTK, inhibitor of Bruton tyrosine kinase, 25998

N. diseases: 33; N. variants: 0
Disease: Diffuse Large B-Cell Lymphoma ×
Source: BEFREE ×
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0079744
Disease: Diffuse Large B-Cell Lymphoma
Diffuse Large B-Cell Lymphoma 		0.020 Biomarker disease BEFREE <b/> In this issue Grommes and colleagues elegantly show that the irreversible inhibitor of Bruton tyrosine kinase, ibrutinib, promotes a high proportion of durable responses in primary central nervous system lymphoma, a type of diffuse large B-cell lymphoma (DLBCL), and also in secondary DLBCL relapsing to the central nervous system. 28864640 2017
CUI: C0079744
Disease: Diffuse Large B-Cell Lymphoma
Diffuse Large B-Cell Lymphoma 		0.020 GeneticVariation disease BEFREE Deletions of CDKN2A/B (28%) and IBTK (23%) were frequent events in relapsed DLBCLs. 27276707 2016