|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The lethal(3)malignant brain tumor (D-l(3)mbt) gene is considered to be one of the tumor suppressor genes of Drosophila, and its recessive mutations are associated with malignant transformation of the neuroblasts in the larval brain.
|
10445843 |
1999 |
|
Malignant neoplasm of brain
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
The lethal(3)malignant brain tumor (D-l(3)mbt) gene is considered to be one of the tumor suppressor genes of Drosophila, and its recessive mutations are associated with malignant transformation of the neuroblasts in the larval brain.
|
10445843 |
1999 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Homozygous mutations in the l(3)mbt gene cause brain tumors in Drosophila, identifying l(3)mbt as a tumor suppressor gene.
|
12588862 |
2003 |
|
Brain Neoplasms
|
0.040 |
GeneticVariation
|
group |
BEFREE |
Homozygous mutations in the l(3)mbt gene cause brain tumors in Drosophila, identifying l(3)mbt as a tumor suppressor gene.
|
12588862 |
2003 |
|
Malignant neoplasm of brain
|
0.040 |
Biomarker
|
disease |
BEFREE |
H-L(3)MBT, the human homolog of the Drosophila lethal(3)malignant brain tumor protein, is a member of the polycomb group (PcG) of proteins, which function as transcriptional regulators in large protein complexes.
|
12588862 |
2003 |
|
Hematopoietic Neoplasms
|
0.030 |
GeneticVariation
|
group |
BEFREE |
The h-l(3)mbt gene maps to chromosome 20q12, within a common deleted region associated with myeloid hematopoietic malignancies.
|
12588862 |
2003 |
|
leukemia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
H-L(3)MBT contains three repeats of 100 residues called MBT repeats, whose function is unknown, and a C-terminal alpha-helical structure, the SPM (SCM, PH, MBT domain, which is structurally similar to the SAM (sterile alpha motif) protein-protein interaction domain, found in several ETS transcription factors, including TEL (translocation Ets leukemia).
|
12588862 |
2003 |
|
Childhood Leukemia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
H-L(3)MBT contains three repeats of 100 residues called MBT repeats, whose function is unknown, and a C-terminal alpha-helical structure, the SPM (SCM, PH, MBT domain, which is structurally similar to the SAM (sterile alpha motif) protein-protein interaction domain, found in several ETS transcription factors, including TEL (translocation Ets leukemia).
|
12588862 |
2003 |
|
Hematopoietic Neoplasms
|
0.030 |
GeneticVariation
|
group |
BEFREE |
We report on the X-ray structure of three 100-amino acid mbt repeats in h-l(3)mbt, a polycomb group protein involved in transcriptional repression, whose gene is located in a region of chromosome 20 associated with hematopoietic malignancies.
|
12842041 |
2003 |
|
Malignant Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
Our results demonstrate that L3MBTL represents a previously undescribed imprinted locus, a vertebrate Polycomb group gene shown to be regulated by this mechanism, and has implications for the pathogenesis of myeloid malignancies associated with 20q deletions.
|
15123827 |
2004 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
L3MBTL is highly homologous to the D-lethal(3) malignant brain tumor [D-l(3)mbt] gene, which is a putative tumor-suppressor gene (TSG) identified in Drosophila and which is closely related to the Drosophila sex combs on midleg (SCM) protein, a member of the Polycomb group (PcG) family of transcriptional repressors.
|
15334543 |
2004 |
|
Malignant neoplasm of brain
|
0.040 |
Biomarker
|
disease |
BEFREE |
L3MBTL is highly homologous to the D-lethal(3) malignant brain tumor [D-l(3)mbt] gene, which is a putative tumor-suppressor gene (TSG) identified in Drosophila and which is closely related to the Drosophila sex combs on midleg (SCM) protein, a member of the Polycomb group (PcG) family of transcriptional repressors.
|
15334543 |
2004 |
|
Leukemia, Myelocytic, Acute
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
However, five leukemia cell lines showed no L3MBTL expression, and two of the AML samples showed aberrant L3MBTL expression.
|
15334543 |
2004 |
|
Myeloproliferative disease
|
0.020 |
Biomarker
|
group |
BEFREE |
The human L3MBTL gene is located in 20q12, a region that is commonly deleted in myeloproliferative disorders (MPD), myelodysplastic syndromes (MDS), and acute myeloid leukemia (AML).
|
15334543 |
2004 |
|
Chronic myeloproliferative disorder
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
These data suggest that L3MBTL is not mutated in MDS or MPD.
|
15334543 |
2004 |
|
Myeloid Leukemia
|
0.010 |
Biomarker
|
disease |
LHGDN |
To examine whether L3MBTL functions as a "classic" TSG in human hematologic malignancies, we screened a panel of 17 myeloid leukemia cell lines and peripheral blood or bone marrow samples from 29 MDS and 13 MPD patients for mutations in the entire L3MBTL coding sequence, including intron/exon splice junctions.
|
15334543 |
2004 |
|
Myeloid Leukemia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
However, given the known dosage effects of PcG proteins in regulating gene expression, reduced or absent L3MBTL expression may be relevant in some cases of myeloid leukemia.
|
15334543 |
2004 |
|
Hematologic Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
To examine whether L3MBTL functions as a "classic" TSG in human hematologic malignancies, we screened a panel of 17 myeloid leukemia cell lines and peripheral blood or bone marrow samples from 29 MDS and 13 MPD patients for mutations in the entire L3MBTL coding sequence, including intron/exon splice junctions.
|
15334543 |
2004 |
|
MYELODYSPLASTIC SYNDROME
|
0.010 |
GeneticVariation
|
group |
BEFREE |
These data suggest that L3MBTL is not mutated in MDS or MPD.
|
15334543 |
2004 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
L3MBTL represents a strong candidate tumour suppressor gene since it lies within the common deleted region, is a member of the Polycomb-like family, encodes the human homologue of a Drosophila tumour suppressor and is expressed within haematopoietic progenitor cells.
|
15566354 |
2004 |
|
Malignant Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
Characterization of the imprinted polycomb gene L3MBTL, a candidate 20q tumour suppressor gene, in patients with myeloid malignancies.
|
15566354 |
2004 |
|
Polycythemia Vera
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
In addition, our results demonstrate that inactivation of L3MBTL is not a common occurrence in patients with a 20q deletion or in cytogenetically normal patients with polycythaemia vera.
|
15566354 |
2004 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
L3MBTL1, the human homolog of the Drosophila L(3)MBT polycomb group tumor suppressor gene, is located on chromosome 20q12, within the common deleted region identified in patients with 20q deletion-associated polycythemia vera, myelodysplastic syndrome, and acute myeloid leukemia.
|
20585043 |
2010 |
|
Leukemia, Myelocytic, Acute
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
L3MBTL1, the human homolog of the Drosophila L(3)MBT polycomb group tumor suppressor gene, is located on chromosome 20q12, within the common deleted region identified in patients with 20q deletion-associated polycythemia vera, myelodysplastic syndrome, and acute myeloid leukemia.
|
20585043 |
2010 |
|
Myeloproliferative disease
|
0.020 |
Biomarker
|
group |
BEFREE |
Our data suggest that haploinsufficiency of L3MBTL1 contributes to some (20q-) myeloproliferative neoplasms, especially polycythemia vera, by promoting erythroid differentiation.
|
20585043 |
2010 |