|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The tumor suppressor L(3)mbt has been shown to secure cellular identity in <i>Drosophila</i> larval brains by repressing germline-specific genes.
|
29511022 |
2018 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Here, we have meta-analyzed gene expression profiles of the human orthologs of Drosophila melanogaster germline genes that are ectopically expressed in l(3)mbt brain tumors using gene expression datasets derived from a large cohort of human tumors.
|
24243547 |
2014 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Further analyses of tumor features among patients indicated that high expression of L3MBTL1 was associated with low grade and hormone receptor-positive tumors, as well as low risk of disease recurrence and breast cancer death.
|
21837478 |
2012 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The tumour suppressor L(3)mbt inhibits neuroepithelial proliferation and acts on insulator elements.
|
21857667 |
2011 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
L3MBTL1 is a human homolog of the Drosophila polycomb L(3)MBT tumor suppressor protein and thus a candidate tumor suppressor in del(20q12) myeloid disorders.
|
21149733 |
2010 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Chromatin protein L3MBTL1 is dispensable for development and tumor suppression in mice.
|
20592034 |
2010 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
L3MBTL1, the human homolog of the Drosophila L(3)MBT polycomb group tumor suppressor gene, is located on chromosome 20q12, within the common deleted region identified in patients with 20q deletion-associated polycythemia vera, myelodysplastic syndrome, and acute myeloid leukemia.
|
20585043 |
2010 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
L3MBTL represents a strong candidate tumour suppressor gene since it lies within the common deleted region, is a member of the Polycomb-like family, encodes the human homologue of a Drosophila tumour suppressor and is expressed within haematopoietic progenitor cells.
|
15566354 |
2004 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
L3MBTL is highly homologous to the D-lethal(3) malignant brain tumor [D-l(3)mbt] gene, which is a putative tumor-suppressor gene (TSG) identified in Drosophila and which is closely related to the Drosophila sex combs on midleg (SCM) protein, a member of the Polycomb group (PcG) family of transcriptional repressors.
|
15334543 |
2004 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Homozygous mutations in the l(3)mbt gene cause brain tumors in Drosophila, identifying l(3)mbt as a tumor suppressor gene.
|
12588862 |
2003 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The lethal(3)malignant brain tumor (D-l(3)mbt) gene is considered to be one of the tumor suppressor genes of Drosophila, and its recessive mutations are associated with malignant transformation of the neuroblasts in the larval brain.
|
10445843 |
1999 |
|
Brain Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
Here, we show that <i>Drosophila</i> l(3)mbt brain tumors are more invasive and develop as malignant neoplasms more often in males than in females.
|
31453329 |
2019 |
|
Malignant neoplasm of brain
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
Mutations in the lethal (3) malignant brain tumor gene (l(3)mbt) have been shown to cause ectopic expression of germline genes, including ping-pong factors.
|
28552546 |
2017 |
|
Brain Neoplasms
|
0.040 |
AlteredExpression
|
group |
BEFREE |
Here, we have meta-analyzed gene expression profiles of the human orthologs of Drosophila melanogaster germline genes that are ectopically expressed in l(3)mbt brain tumors using gene expression datasets derived from a large cohort of human tumors.
|
24243547 |
2014 |
|
Brain Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
We demonstrate that brain tumours in l(3)mbt mutants originate from overproliferation of neuroepithelial cells in the optic lobes caused by derepression of target genes in the Salvador-Warts-Hippo (SWH) pathway.
|
21857667 |
2011 |
|
Malignant neoplasm of brain
|
0.040 |
Biomarker
|
disease |
BEFREE |
L3MBTL is highly homologous to the D-lethal(3) malignant brain tumor [D-l(3)mbt] gene, which is a putative tumor-suppressor gene (TSG) identified in Drosophila and which is closely related to the Drosophila sex combs on midleg (SCM) protein, a member of the Polycomb group (PcG) family of transcriptional repressors.
|
15334543 |
2004 |
|
Brain Neoplasms
|
0.040 |
GeneticVariation
|
group |
BEFREE |
Homozygous mutations in the l(3)mbt gene cause brain tumors in Drosophila, identifying l(3)mbt as a tumor suppressor gene.
|
12588862 |
2003 |
|
Malignant neoplasm of brain
|
0.040 |
Biomarker
|
disease |
BEFREE |
H-L(3)MBT, the human homolog of the Drosophila lethal(3)malignant brain tumor protein, is a member of the polycomb group (PcG) of proteins, which function as transcriptional regulators in large protein complexes.
|
12588862 |
2003 |
|
Malignant neoplasm of brain
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
The lethal(3)malignant brain tumor (D-l(3)mbt) gene is considered to be one of the tumor suppressor genes of Drosophila, and its recessive mutations are associated with malignant transformation of the neuroblasts in the larval brain.
|
10445843 |
1999 |
|
Malignant Neoplasms
|
0.030 |
GeneticVariation
|
group |
BEFREE |
The l3mbtl1 gene is located on the long arm of chromosome 20 (q12), within a region commonly deleted in several myeloid malignancies.
|
21149733 |
2010 |
|
Hematopoietic Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
We propose that the loss of L3MBTL1 contributes to the development of 20q(-) hematopoietic malignancies by inducing replicative stress, DNA damage, and genomic instability.
|
21149733 |
2010 |
|
Malignant Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
Our results demonstrate that L3MBTL represents a previously undescribed imprinted locus, a vertebrate Polycomb group gene shown to be regulated by this mechanism, and has implications for the pathogenesis of myeloid malignancies associated with 20q deletions.
|
15123827 |
2004 |
|
Malignant Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
Characterization of the imprinted polycomb gene L3MBTL, a candidate 20q tumour suppressor gene, in patients with myeloid malignancies.
|
15566354 |
2004 |
|
Hematopoietic Neoplasms
|
0.030 |
GeneticVariation
|
group |
BEFREE |
We report on the X-ray structure of three 100-amino acid mbt repeats in h-l(3)mbt, a polycomb group protein involved in transcriptional repression, whose gene is located in a region of chromosome 20 associated with hematopoietic malignancies.
|
12842041 |
2003 |
|
Hematopoietic Neoplasms
|
0.030 |
GeneticVariation
|
group |
BEFREE |
The h-l(3)mbt gene maps to chromosome 20q12, within a common deleted region associated with myeloid hematopoietic malignancies.
|
12588862 |
2003 |