|
Anorexia Nervosa
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Protein expression in PBMCs of cyclooxygenase-2 (COX-2) and the activated forms of the mitogen-activated protein kinases p38 and ERK were also increased in the AN group.
|
31398429 |
2020 |
|
beta Thalassemia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Oridonin enhances γ‑globin expression in erythroid precursors from patients with β‑thalassemia via activation of p38 MAPK signaling.
|
31789406 |
2020 |
|
Jaundice, Obstructive
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
All these data demonstrated that p38 MAPK-pHsp27 mediates vascular hyporesponsiveness in rats with obstructive jaundice by modulating the expression level of pHsp27 and F-actin, and that inhibition of p38 MAPK signaling could remodel the vascular activity.
|
31810142 |
2020 |
|
Retinitis Pigmentosa
|
0.010 |
Biomarker
|
disease |
BEFREE |
The mechanism might be related to inhibit the activation of P38 pathway.<b>Conclusions:</b> This study showed the beneficial effects of DHAG, a compound possessing antioxidant properties, and provided scientific rationale to develop DHAG as a potential agent to treat RP.
|
31648555 |
2020 |
|
Skin Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
Hyperoside markedly inhibited diffuse epidermal hyperplasia and significantly reduced the changes in phosphorylated levels of PI3K, AKT, mTOR and AMPK while reducing p38 phosphorylation as well as of tumor burden <i>in vivo</i> in DMBA/TPA induced skin tumors.
|
31585897 |
2020 |
|
Influenza A virus infection
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In this study, we demonstrated that p38 MAPK-mediated matrix metalloproteinase-13 expression by influenza A virus infection led to destabilization of vulnerable atherosclerotic plaques in artery.(191 words).
|
31693113 |
2020 |
|
precancerous lesions
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
DFMO was also found to suppress the development of esophageal precancerous lesions in an NMBA-induced rat model; IHC demonstrated p38 α, ERK1/2, and AKT/mTOR/p70S6K pathways to be downregulated in these rats.
|
31793679 |
2020 |
|
Influenza A
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, the expression of matrix metalloproteinase-13 was regulated by influenza A virus through activation of the p38 MAPK signal pathway.
|
31693113 |
2020 |
|
beta^+^ Thalassemia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Oridonin enhances γ‑globin expression in erythroid precursors from patients with β‑thalassemia via activation of p38 MAPK signaling.
|
31789406 |
2020 |
|
Neointimal hyperplasia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Though homozygous deletion of Poldip2 is lethal, heterozygous mice are viable and show protection against aneurysm and injury-induced neointimal hyperplasia, diseases linked to loss of VSMC differentiation.
|
31656131 |
2020 |
|
Exacerbation of allergic asthma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Blocking TRPV4or p38 MAPK using HC-067047 and SB203580 respectively, effectively alleviated the exacerbation of allergic asthma induced by this simultaneous exposure to formaldehyde and high relative humidity.
|
31662264 |
2020 |
|
AIDS related complex
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Taken together, our results implied that the elevated LMα4, which was possibly caused by the decreased MMP-9, increased TGF-β1 and activated p38 MAPK signaling during senescence, leading to the development of ARC.
|
31076560 |
2019 |
|
Anemia, Sickle Cell
|
0.010 |
Biomarker
|
disease |
BEFREE |
<b>Materials and methods:</b> Humanized mouse model with SCD defined as moderate- and non-responders to EA were intraperitoneally administered with antagonist of SP receptor NK1R (netupitant, 10 mg/kg/day, i.p.) or p38 MAPK inhibitor (SB203580, 10 mg/kg/day, i.p.) alone or in combination with EA (acupoint GB30, every 3rd day until day 12).
|
31447579 |
2019 |
|
Chikungunya Fever
|
0.010 |
Biomarker
|
disease |
BEFREE |
A strong polar interaction was predicted between Thr-180 (within the phosphorylation lip) of p38 and Gln-273 of nsP2, whereas, no such polar interaction was predicted for the phosphorylation lip of JNK which indicates the differential roles of p-p38 and p-JNK during CHIKV infection in the host macrophages.
|
31031770 |
2019 |
|
Peptic Esophagitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Additionally, treatment with isorhamnetin inhibited p38 MAPK and NFκB activation in RE esophagus.
|
31586635 |
2019 |
|
Fatigue
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Our findings identify that penfluridol acts as an inducer of ER stress and p38 MAPK activation, which led to UPR-mediated nonapoptotic cell death via autophagosome accumulation-caused energy loss.
|
31308361 |
2019 |
|
Fetal Alcohol Syndrome
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our study supplies the evidence supporting the molecular mechanism by which ropivacaine activates the MAPK/p38/Fas signal to promote neurogliocyte apoptosis and suggests that the combination of p38 inhibitor with ropivacaine might be an effective strategy to decrease the ropivacaine-caused neurogliotoxicity.
|
31028842 |
2019 |
|
IGA Glomerulonephritis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Assessment of kidney biopsy specimens from IgA nephropathy patients revealed that the degree of interstitial fibrosis was significantly associated with the tissue immunoactivity of phosphorylated p38.
|
30897126 |
2019 |
|
Guillain-Barre Syndrome
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
GBS infection increased levels of total and phosphorylated mitogen-activated protein kinase (MAPK) family members such as p38 and JNK and induced nuclear factor kappa B (NF-κB) pathway activation.
|
31548323 |
2019 |
|
Hemolytic-Uremic Syndrome
|
0.010 |
Biomarker
|
disease |
BEFREE |
Enterohemorrhagic <i>Escherichia coli</i> (EHEC) is a pathological strain that can induce mitogen-activated protein (MAP) kinase (Erk, Jnk and p38 MAPK) and NF-κB pathway activation and proinflammatory cytokine production, which then causes diarrheal diseases such as hemorrhagic colitis and hemolytic uremic syndrome.
|
31130074 |
2019 |
|
Hyperlipidemia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Hyperlipidemia enhanced the expression of p-MLC and MLCK, which were associated with the increased phosphorylation of ERK, p38 and JNK.
|
30651770 |
2019 |
|
Immunologic Deficiency Syndromes
|
0.010 |
AlteredExpression
|
group |
BEFREE |
By contrast, downregulation of p38 MAPK by SB203580 enhanced expression of HO-1 and iNOS and decreased migration of leukemic cells in vitro and their seeding efficiency to vital organs in vivo after injection into immunodeficient mice.
|
30302660 |
2019 |
|
Male infertility
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
Therefore, these results demonstrate that inhibition of p38 activity prevents CdCl<sub>2</sub>-induced apoptotic GC-2spd cell death by reducing depolarization of mitochondrial membrane potential and mitochondrial ROS levels via ERK phosphorylation in a signal pathway different from the CdCl<sub>2</sub>-induced ERK/Drp1/p38 axis and suggest a therapeutic strategy for CdCl<sub>2</sub>-induced male infertility.
|
31676320 |
2019 |
|
Mycosis Fungoides
|
0.010 |
Biomarker
|
group |
BEFREE |
Our work provided direct evidences for effects of SHARPIN on JNKs and NF-κB pathway, and the contributing roles of JNKs, NF-κB and p38 pathway regulated by SHARPIN in the development of MF.
|
31461795 |
2019 |
|
Myocarditis
|
0.010 |
Biomarker
|
disease |
BEFREE |
<i>Scutellaria baicalensis</i> Inhibits Coxsackievirus B3-Induced Myocarditis Via AKT and p38 Pathways.
|
31370111 |
2019 |