|
nervous system disorder
|
0.010 |
Biomarker
|
group |
BEFREE |
The three classical MAPK subfamilies, extracellular signal-regulated kinase 1 and 2 (ERK1/2), c-Jun N-terminal kinase (JNK), and p38 kinase have been linked to various neurological disorders often in conjunction with activation of a wide range of G protein-coupled receptors and receptor tyrosine kinases.
|
30983972 |
2019 |
|
Osteoporosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Taken together, these results suggest that TAT-TN13 inhibits osteoclast differentiation by regulating the p38 and NF-κB signaling pathway; thus, it may be a useful agent for preventing or treating osteoporosis.
|
30934850 |
2019 |
|
Pancreatitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Inhibition of p38 activation resulted in alleviated pancreatitis.
|
31432106 |
2019 |
|
Familial Mediterranean Fever
|
0.010 |
Biomarker
|
disease |
BEFREE |
Based on preliminary data by our group suggesting an upregulation of the mitogen-activated protein kinases (MAPKs) in human lymphocytes exposed to dabrafenib and trametinib, specifically elevated expression of phosphorylated JNK (p-JNK), p38 MAPK (p-p38 MAPK), and ERK5 (p-ERK5), we hypothesized that the mechanism of MAPK pathway activation with DT therapy is similar to that reported in patients with familial Mediterranean fever (FMF), a rare, inherited condition characterized by episodes of fever and rash that responds exceedingly well to colchicine-based therapy in which the MAPK pathway is hyper-activated.
|
30767130 |
2019 |
|
Peripheral Neuropathy
|
0.010 |
PosttranslationalModification
|
group |
BEFREE |
Collectively these data suggest that spinal P450c17 activates astrocytes via p38 phosphorylation, ultimately leading to the development of mechanical allodynia in a model of peripheral neuropathy.
|
31387001 |
2019 |
|
Pituitary Adenoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
The combined use of ERK inhibitor (e.g., SOM230, OCT, or dopamine) plus p38 activator (e.g., cabergoline, bromocriptine, and fulvestrant) and/or JNK activator (e.g., UA), or the development of single drug (e.g., BIM-23A760) to target both ERK and p38 or JNK pathways, might produce better anti-tumor effects on PAs.
|
31231308 |
2019 |
|
Ankylosing spondylitis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Despite the lower basal expression of TLRs, AS-MSCs were as sensitive or more sensitive to TLR agonists as compared with HD-MSCs in terms of activation of p38 and ERK MAPK signaling pathways.
|
31456484 |
2019 |
|
Status Epilepticus
|
0.010 |
Biomarker
|
disease |
BEFREE |
Roscovitine Attenuates Microglia Activation and Monocyte Infiltration via p38 MAPK Inhibition in the Rat Frontoparietal Cortex Following Status Epilepticus.
|
31331032 |
2019 |
|
Stress, Psychological
|
0.010 |
Biomarker
|
disease |
BEFREE |
β-Endorphin Induction by Psychological Stress Promotes Leydig Cell Apoptosis through p38 MAPK Pathway in Male Rats.
|
31623282 |
2019 |
|
Thymoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In experimental models of disease, the carotenoid astaxanthin has been shown to modulate autophagy by regulating signaling pathways, including the AMP-activated protein kinase (AMPK), cellular homolog of murine thymoma virus akt8 oncogene (Akt), and mitogen-activated protein kinase (MAPK), such as c-Jun N-terminal kinase (JNK) and p38.
|
31547619 |
2019 |
|
Tuberous Sclerosis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Accompanying this improvement was correction of activity in the p38 MAPK-TSC-Rheb-mTORC1-S6K1 pathway.
|
30928642 |
2019 |
|
Ureteral obstruction
|
0.010 |
PosttranslationalModification
|
phenotype |
BEFREE |
In a mouse UUO model, renal protein expression of COL1 and phosphorylated p38 were significantly increased, and the protein expression of COL1 and phosphorylated p38 decreased in mice administered 10 mg/kg/day p38 MAPK inhibitor.
|
30897126 |
2019 |
|
Diffuse Large B-Cell Lymphoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Newly formed NETs directly upregulated the Toll-like receptor 9 (TLR9) pathways in DLBCL and subsequently activated NFκB, STAT3, and p38 pathways to promote tumor progression.
|
30446590 |
2019 |
|
Bicuspid aortic valve
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The senescent-collagenolytic SMC phenotype depended on p38 MAPK signaling, which was chronically activated in BAV aortas.
|
31078518 |
2019 |
|
Hemorrhagic colitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Enterohemorrhagic <i>Escherichia coli</i> (EHEC) is a pathological strain that can induce mitogen-activated protein (MAP) kinase (Erk, Jnk and p38 MAPK) and NF-κB pathway activation and proinflammatory cytokine production, which then causes diarrheal diseases such as hemorrhagic colitis and hemolytic uremic syndrome.
|
31130074 |
2019 |
|
Adrenoleukodystrophy
|
0.010 |
PosttranslationalModification
|
disease |
BEFREE |
GME attenuated ALD through inhibiting the phosphorylation of JNK and P38 and further suppressing the initiation of inflammation.
|
30298517 |
2019 |
|
Aortic Aneurysm, Abdominal
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Inhibition of Iars significantly reduced the incidence of angiotensin II (AngII)-induced AAA in mice, coincident with decreased activity of the p38 MAPK pathway and increased PI3K pathway activity.
|
30905780 |
2019 |
|
Adult Liver Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Moreover, SATB1 expression and anoikis resistance were mainly regulated by HBV-encoded viral protein HBx through the activation of ERK and p38 MAPK signaling pathways to promote metastasis of liver cancer.
|
31147803 |
2019 |
|
Muscular Dystrophy, Facioscapulohumeral
|
0.010 |
Biomarker
|
disease |
BEFREE |
We propose p38 inhibition as a disease-modifying therapeutic strategy for FSHD.
|
31189728 |
2019 |
|
Acute hepatitis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
In this study, we found that a mutation of alternative p38 in mice augmented the severity of acute liver inflammation.
|
31780731 |
2019 |
|
Mink parvovirus infection
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Taken together, our results demonstrated that MEV induces apoptosis through activation of p38 MAPK and the p53-mediated mitochondrial apoptotic pathway induced by NS1 protein, which sheds light on the molecular pathogenesis of MEV infection.<b>IMPORTANCE</b> MEV causes fatal hemorrhagic enteritis in minks.
|
31484746 |
2019 |
|
Radicular pain
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
Spinal SFKs contribute to radicular pain by activation of p38 MAPK and increasing pro-inflammatory cytokines expression in rats with NP implantation.
|
31261268 |
2019 |
|
Liver and Intrahepatic Biliary Tract Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Moreover, SATB1 expression and anoikis resistance were mainly regulated by HBV-encoded viral protein HBx through the activation of ERK and p38 MAPK signaling pathways to promote metastasis of liver cancer.
|
31147803 |
2019 |
|
Malignant neoplasm of liver
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Moreover, SATB1 expression and anoikis resistance were mainly regulated by HBV-encoded viral protein HBx through the activation of ERK and p38 MAPK signaling pathways to promote metastasis of liver cancer.
|
31147803 |
2019 |
|
AICARDI-GOUTIERES SYNDROME
|
0.010 |
Biomarker
|
disease |
BEFREE |
Notably, DRP1 knockdown or SB203580-induced p38 inhibition reduced indomethacin-induced damage to AGSs.
|
30940726 |
2019 |