|
Coronary Artery Disease
|
0.110 |
GeneticVariation
|
disease |
GWASCAT |
Identification of 64 Novel Genetic Loci Provides an Expanded View on the Genetic Architecture of Coronary Artery Disease.
|
29212778 |
2018 |
|
Coronary Artery Disease
|
0.110 |
GeneticVariation
|
disease |
GWASCAT |
Genetic analysis in UK Biobank links insulin resistance and transendothelial migration pathways to coronary artery disease.
|
28714974 |
2017 |
|
Coronary Artery Disease
|
0.110 |
GeneticVariation
|
disease |
GWASCAT |
Association analyses based on false discovery rate implicate new loci for coronary artery disease.
|
28714975 |
2017 |
|
Coronary Artery Disease
|
0.110 |
Biomarker
|
disease |
BEFREE |
We also identified SGEF as a candidate gene in one of the novel CAD loci.
|
28584231 |
2017 |
|
Waist-Hip Ratio
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
Systolic Pressure
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Trans-ethnic association study of blood pressure determinants in over 750,000 individuals.
|
30578418 |
2019 |
|
Schizophrenia
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association study of schizophrenia in Ashkenazi Jews.
|
26198764 |
2015 |
|
Glioblastoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Previous observations indicated that SGEF (ARHGEF26), a RhoG-specific guanine nucleotide exchange factor (GEF), is overexpressed in GB tumors and plays a role in promoting TWEAK-Fn14-mediated glioma invasion.
|
26764186 |
2016 |
|
Glioma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Here, further investigation revealed an important role for SGEF in glioma cell survival.
|
26764186 |
2016 |
|
Neoplasms
|
0.020 |
Biomarker
|
group |
BEFREE |
Previous observations indicated that SGEF (ARHGEF26), a RhoG-specific guanine nucleotide exchange factor (GEF), is overexpressed in GB tumors and plays a role in promoting TWEAK-Fn14-mediated glioma invasion.
|
26764186 |
2016 |
|
Adult Glioblastoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Previous observations indicated that SGEF (ARHGEF26), a RhoG-specific guanine nucleotide exchange factor (GEF), is overexpressed in GB tumors and plays a role in promoting TWEAK-Fn14-mediated glioma invasion.
|
26764186 |
2016 |
|
Childhood Glioblastoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Previous observations indicated that SGEF (ARHGEF26), a RhoG-specific guanine nucleotide exchange factor (GEF), is overexpressed in GB tumors and plays a role in promoting TWEAK-Fn14-mediated glioma invasion.
|
26764186 |
2016 |
|
Tumor Cell Invasion
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
Previous observations indicated that SGEF (ARHGEF26), a RhoG-specific guanine nucleotide exchange factor (GEF), is overexpressed in GB tumors and plays a role in promoting TWEAK-Fn14-mediated glioma invasion.
|
26764186 |
2016 |
|
Glioblastoma Multiforme
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Previous observations indicated that SGEF (ARHGEF26), a RhoG-specific guanine nucleotide exchange factor (GEF), is overexpressed in GB tumors and plays a role in promoting TWEAK-Fn14-mediated glioma invasion.
|
26764186 |
2016 |
|
Glioblastoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Mutation of the Fn14-TRAF domain site or depletion of TNF receptor-associated factor 2 (TRAF2) expression by siRNA oligonucleotides blocked SGEF recruitment to Fn14 and inhibited SGEF activity and subsequent GB cell migration.
|
23775076 |
2013 |
|
Glioma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
SGEF mRNA expression is increased in GB cells at the invasive rim relative to those in the tumor core, and knockdown of SGEF expression by shRNA decreases glioma cell migration in vitro and invasion ex vivo.
|
23775076 |
2013 |
|
Neoplasms
|
0.020 |
AlteredExpression
|
group |
BEFREE |
SGEF mRNA expression is increased in GB cells at the invasive rim relative to those in the tumor core, and knockdown of SGEF expression by shRNA decreases glioma cell migration in vitro and invasion ex vivo.
|
23775076 |
2013 |
|
Adult Glioblastoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Mutation of the Fn14-TRAF domain site or depletion of TNF receptor-associated factor 2 (TRAF2) expression by siRNA oligonucleotides blocked SGEF recruitment to Fn14 and inhibited SGEF activity and subsequent GB cell migration.
|
23775076 |
2013 |
|
Childhood Glioblastoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Mutation of the Fn14-TRAF domain site or depletion of TNF receptor-associated factor 2 (TRAF2) expression by siRNA oligonucleotides blocked SGEF recruitment to Fn14 and inhibited SGEF activity and subsequent GB cell migration.
|
23775076 |
2013 |
|
Tumor Cell Invasion
|
0.020 |
AlteredExpression
|
phenotype |
BEFREE |
SGEF mRNA expression is increased in GB cells at the invasive rim relative to those in the tumor core, and knockdown of SGEF expression by shRNA decreases glioma cell migration in vitro and invasion ex vivo.
|
23775076 |
2013 |
|
Glioblastoma Multiforme
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Mutation of the Fn14-TRAF domain site or depletion of TNF receptor-associated factor 2 (TRAF2) expression by siRNA oligonucleotides blocked SGEF recruitment to Fn14 and inhibited SGEF activity and subsequent GB cell migration.
|
23775076 |
2013 |
|
Arteriosclerosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Taken together, these results show for the first time that a Rho-GEF, namely SGEF, contributes to the formation of atherosclerosis by promoting endothelial docking structures and thereby retention of leukocytes at athero-prone sites of inflammation experiencing high shear flow.
|
23372835 |
2013 |
|
Atherosclerosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Taken together, these results show for the first time that a Rho-GEF, namely SGEF, contributes to the formation of atherosclerosis by promoting endothelial docking structures and thereby retention of leukocytes at athero-prone sites of inflammation experiencing high shear flow.
|
23372835 |
2013 |