This study revealed four key findings for HIV-positive patients: <i>1</i>) coexpression of the CD142 coagulation marker together with immune activation on both CD4<sup>+</sup> and CD8<sup>+</sup> T cells during chronic infection stages; <i>2</i>) Treg cell activation and upregulated GARP and SATB-1 contributing to Treg dysfunction in chronic HIV; <i>3</i>) proatherogenic monocyte subset expansion with significant correlation between T-cell activation and macrophage activation (marker: CD163); and <i>4</i>) significant correlation between immune activation and lipid subclasses, revealing crucial changes that can be missed by traditional lipid marker assessments (LDL and HDL).