|
Global developmental delay
|
0.110 |
GeneticVariation
|
disease |
BEFREE |
We identified a homozygous stop-gain variant in LRRC32 (c.1630C>T; p.(Arg544Ter)) in two families with developmental delay, cleft palate, and proliferative retinopathy.
|
30976112 |
2019 |
|
Uranostaphyloschisis
|
0.110 |
GeneticVariation
|
disease |
BEFREE |
Homozygous stop-gain variant in LRRC32, encoding a TGFβ receptor, associated with cleft palate, proliferative retinopathy, and developmental delay.
|
30976112 |
2019 |
|
Global developmental delay
|
0.110 |
GeneticVariation
|
disease |
CLINVAR |
|
|
|
|
Uranostaphyloschisis
|
0.110 |
GeneticVariation
|
disease |
CLINVAR |
|
|
|
|
Herpes zoster disease
|
0.100 |
GeneticVariation
|
group |
GWASCAT |
The eMERGE genotype set of 83,717 subjects imputed to ~40 million variants genome wide and association with the herpes zoster medical record phenotype.
|
30298529 |
2019 |
|
Allergic Reaction
|
0.100 |
GeneticVariation
|
phenotype |
GWASDB |
A genome-wide association meta-analysis of self-reported allergy identifies shared and allergy-specific susceptibility loci.
|
23817569 |
2013 |
|
Vitreoretinal degeneration
|
0.100 |
GeneticVariation
|
disease |
CLINVAR |
|
|
|
|
Malignant Neoplasms
|
0.060 |
AlteredExpression
|
group |
BEFREE |
Thus, GARP empowers the functionality of Treg cells and their tissue-specific accumulation, highlighting the importance of cell surface TGFβ in Treg function and GARP as a potential therapeutic target for colorectal cancer therapy.<b>Significance:</b> These findings uncover functions of membrane-bound TGFβ and GARP that tune the activity of Treg cells, highlighting a potential treatment strategy in autoimmune diseases and cancer.
|
30674536 |
2019 |
|
Malignant Neoplasms
|
0.060 |
Biomarker
|
group |
BEFREE |
These results, if confirmed by independent investigations, will aid in devising personalized GARP-based immunotherapeutic strategies against breast cancer and other GARP-overexpressing malignancies.
|
29879453 |
2018 |
|
Malignant Neoplasms
|
0.060 |
Biomarker
|
group |
BEFREE |
While GARP is implicated in immune invasion in cancer, the roles of the GARP-TGF-β axis in systemic autoimmune diseases are unknown.
|
29618665 |
2018 |
|
Malignant Neoplasms
|
0.060 |
Biomarker
|
group |
BEFREE |
The promise for GARP-targeted strategy as a novel immunotherapy of cancer is also highlighted.
|
29458436 |
2018 |
|
Malignant Neoplasms
|
0.060 |
Biomarker
|
group |
BEFREE |
Platelets subvert T cell immunity against cancer via GARP-TGFβ axis.
|
28763790 |
2017 |
|
Malignant Neoplasms
|
0.060 |
Biomarker
|
group |
BEFREE |
As Treg-derived TGF-β may mediate the suppressive functions of Tregs, GARP may represent a target to inhibit Treg suppression in cancer or augment suppression in autoimmunity.
|
28001437 |
2017 |
|
Primary malignant neoplasm
|
0.050 |
AlteredExpression
|
group |
BEFREE |
Thus, GARP empowers the functionality of Treg cells and their tissue-specific accumulation, highlighting the importance of cell surface TGFβ in Treg function and GARP as a potential therapeutic target for colorectal cancer therapy.<b>Significance:</b> These findings uncover functions of membrane-bound TGFβ and GARP that tune the activity of Treg cells, highlighting a potential treatment strategy in autoimmune diseases and cancer.
|
30674536 |
2019 |
|
Neoplasms
|
0.050 |
Biomarker
|
group |
BEFREE |
Deletion of GARP on mouse regulatory T cells is not sufficient to inhibit the growth of transplanted tumors.
|
30093071 |
2018 |
|
Primary malignant neoplasm
|
0.050 |
Biomarker
|
group |
BEFREE |
While GARP is implicated in immune invasion in cancer, the roles of the GARP-TGF-β axis in systemic autoimmune diseases are unknown.
|
29618665 |
2018 |
|
Primary malignant neoplasm
|
0.050 |
Biomarker
|
group |
BEFREE |
The promise for GARP-targeted strategy as a novel immunotherapy of cancer is also highlighted.
|
29458436 |
2018 |
|
Neoplasms
|
0.050 |
GeneticVariation
|
group |
BEFREE |
Platelet-specific deletion of the GARP-encoding gene <i>Lrrc32</i> blunted TGFβ activity at the tumor site and potentiated protective immunity against both melanoma and colon cancer.
|
28763790 |
2017 |
|
Primary malignant neoplasm
|
0.050 |
Biomarker
|
group |
BEFREE |
As Treg-derived TGF-β may mediate the suppressive functions of Tregs, GARP may represent a target to inhibit Treg suppression in cancer or augment suppression in autoimmunity.
|
28001437 |
2017 |
|
Primary malignant neoplasm
|
0.050 |
Biomarker
|
group |
BEFREE |
Platelets subvert T cell immunity against cancer via GARP-TGFβ axis.
|
28763790 |
2017 |
|
Neoplasms
|
0.050 |
AlteredExpression
|
group |
BEFREE |
Interestingly, membrane bound GARP is shed from the surface of both, activated Treg and melanoma cells, and, in its soluble form (sGARP), not only induces peripheral Treg but also a tumor associated (M2) macrophage phenotype.
|
27248166 |
2016 |
|
Neoplasms
|
0.050 |
Biomarker
|
group |
BEFREE |
Apart from the known differentially expressed genes on 11q13 (e.g., phosphofurin acidic cluster sorting protein 1 (PACS1) and FOS ligand 1 (FOSL1 or Fra-1)), we detected novel differentially expressed cellular genes located within the tumor suppressor gene region (e.g., EGF-containing fibulin-like extracellular matrix protein 2 (EFEMP2) and leucine rich repeat containing 32 (LRRC32) (also known as glycoprotein-A repetitions predominant (GARP)) that may have potential tumor suppressor functions in this model system of non-tumorigenic and tumorigenic HeLa x fibroblast hybrid cells.
|
24042169 |
2013 |
|
Degenerative polyarthritis
|
0.050 |
Biomarker
|
disease |
BEFREE |
To identify regulating genes in innate immunity, we analyzed data from a genome-wide linkage scan using microsatellites in osteoarthritis (OA) patients (The GARP study) and their innate cytokine data on interleukin (IL)-1beta, IL-1Ra, IL-10 and tumor necrosis factor (TNF)alpha.
|
20407468 |
2010 |
|
Degenerative polyarthritis
|
0.050 |
Biomarker
|
disease |
BEFREE |
Allele-sharing methods were applied to the symptomatic osteoarthritis GARP study where taking into account the family-history increased considerably the evidence of linkage in the region of the DIO2 susceptibility locus.
|
20707788 |
2010 |
|
Degenerative polyarthritis
|
0.050 |
GeneticVariation
|
disease |
BEFREE |
To identify a new osteoarthritis susceptibility locus, a genome-wide linkage scan and combined linkage association analysis were applied to 179 affected siblings and four trios with generalized osteoarthritis (The GARP study).
|
18334578 |
2008 |