|
Holoprosencephaly
|
0.430 |
Biomarker
|
disease |
BEFREE |
Clinical manifestations presented by these patients suggest that GAS1 could be considered a candidate locus for one of the types of human HPE.
|
20583177 |
2010 |
|
Holoprosencephaly
|
0.430 |
GeneticVariation
|
disease |
BEFREE |
Missense substitutions in the GAS1 protein present in holoprosencephaly patients reduce the affinity for its ligand, SHH.
|
21842183 |
2012 |
|
Holoprosencephaly
|
0.430 |
Biomarker
|
disease |
BEFREE |
Gas1(-/-) mice exhibited microform HPE, including midfacial hypoplasia, premaxillary incisor fusion, and cleft palate, in addition to severe ear defects; however, gross integrity of the forebrain remained intact.
|
17525797 |
2007 |
|
Cleft Palate
|
0.110 |
Biomarker
|
disease |
BEFREE |
As human GAS1 maps to chromosome 9q21.3-q22, a region previously associated with nonsyndromic cleft palate and congenital deafness, our results establish GAS1 as a potential locus for several human craniofacial malformations.
|
17525797 |
2007 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The human growth-arrest specific gene GAS1 maps to chromosome bands 9q21.3-->q22, the region known to contain the tumour suppressor gene responsible for nevoid basal cell carcinoma syndrome (NBCCS).
|
7956349 |
1995 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
We describe here the diagnostic power of a novel 8-genes signature: ornithine decarboxylase (ODC), ornithine decarboxylase antizyme (OAZ), adenosylmethionine decarboxylase (AdoMetDC), spermidine/spermine N(1)-acetyltransferase (SSAT), histone H3 (H3), growth arrest specific gene (GAS1), glyceraldehyde 3-phosphate dehydrogenase (GAPDH) and Clusterin (CLU) in tumour detection/classification of human CaP.
|
18974881 |
2008 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Furthermore, retroviral-mediated transfer of gas1 to gliomas implanted in nude mice induces a significant inhibition of tumor growth, accompanied by increased caspase-3 activation.
|
15056455 |
2004 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Our results indicate that the targeted expression of tumor suppressor genes (gas1 and p53) regulated by the gfa2 promoter, together with adenoviral vectors may provide an interesting approach for adjuvant selective glioma gene therapy.
|
17599090 |
2007 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Up-regulation of histone H3 and down-regulation of growth arrest-specific gene 1 (Gas1) mRNAs in CaP-developing TRAMP mice demonstrated a high proliferation rate in tumors, while the opposite occurred in the glands of GTC chemoprevented animals.
|
15358631 |
2004 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The growth arrest-specific gene (GAS1), a candidate tumor suppressor gene, was included within the proximal minimal region.
|
8895761 |
1996 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The potential of Gas1 as an adjuvant in the treatment of cancer, and its role as a tumor suppressor have also been proposed.
|
19460624 |
2009 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Exogenous IL-11 but not IL-6 activated oncogenic signal transducer and activator of transcription-3, and altered expression of novel proliferative and cytoprotective genes RegIII-beta, RegIII-gamma, gremlin-1, clusterin, and growth arrest specific-1 in wild-type gastric mucosa, a gene signature common in gp130(757F/F) and HKbeta-/- tumors as well as nonneoplastic mucosa of gastric cancer patients.
|
19121317 |
2009 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
We further demonstrated that Gas1 has all the expected properties of a melanoma tumor suppressor including: suppression of metastasis in a spontaneous metastasis assay, promotion of apoptosis following dissemination of cells to secondary sites, and frequent down-regulation in human melanoma metastasis-derived cell lines and metastatic tumor samples.
|
18981472 |
2008 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Growth arrest-specific gene 1 is downregulated and inhibits tumor growth in gastric cancer.
|
22846196 |
2012 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
On the other hand, several studies have shown the interaction between Gas1 and Hh (Hedgehog) proteins to potentiate the positive regulation of this pathway, which is involved in the development of the nervous system, and in both the origin and progression of different tumors.
|
25429664 |
2014 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
A soluble form of GAS1 inhibits tumor growth and angiogenesis in a triple negative breast cancer model.
|
24992044 |
2014 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Therefore, it is relevant to investigate the potential additive effect of the overexpression of GAS1 and PTEN on tumor growth.
|
29941984 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Growth arrest specific1 (GAS1) protein is a tumor suppressor that inhibits cancer cell proliferation and induces apoptosis through inhibition of RET receptor tyrosine kinase.
|
24220341 |
2013 |
|
Glioma
|
0.050 |
Biomarker
|
disease |
BEFREE |
Growth arrest specific-1 (Gas1) is a protein that induces cell arrest and apoptosis of gliomas and a soluble form, tGas1, increases these effects acting in both autocrine and paracrine manners.
|
24529556 |
2014 |
|
Glioma
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
Glial-specific retrovirally mediated gas1 gene expression induces glioma cell apoptosis and inhibits tumor growth in vivo.
|
15056455 |
2004 |
|
Glioma
|
0.050 |
Biomarker
|
disease |
BEFREE |
We suggest that Gas1 does not act in combination with p53 in the C6 and U373 glioma cell lines, inducing apoptosis and cell cycle arrest.
|
17599090 |
2007 |
|
Glioma
|
0.050 |
Biomarker
|
disease |
BEFREE |
In the present work, we present evidence demonstrating that Gas1 exerts its effects inhibiting cell growth and inducing apoptosis of glioma cells in the absence of Shh.
|
19460624 |
2009 |
|
Glioma
|
0.050 |
Biomarker
|
disease |
BEFREE |
Lentiviral transfer of an inducible transgene expressing a soluble form of Gas1 causes glioma cell arrest, apoptosis and inhibits tumor growth.
|
20885451 |
2011 |
|
Malignant Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
Gas1 is a pleiotropic regulator of cellular functions: from embryonic development to molecular actions in cancer gene therapy.
|
25429664 |
2014 |
|
Malignant Neoplasms
|
0.040 |
AlteredExpression
|
group |
BEFREE |
Occludin (OCLN) and growth arrest-specific 1 (GAS1) genes were underexpressed in ccRCC, and we report that miR-122 and miR-34a, respectively, may regulate their expression in this cancer.
|
28184927 |
2017 |