|
Lobar Holoprosencephaly
|
0.500 |
Biomarker
|
disease |
CTD_human |
Gas1 is a modifier for holoprosencephaly and genetically interacts with sonic hedgehog.
|
17525797 |
2007 |
|
Alobar Holoprosencephaly
|
0.500 |
Biomarker
|
disease |
CTD_human |
Gas1 is a modifier for holoprosencephaly and genetically interacts with sonic hedgehog.
|
17525797 |
2007 |
|
Semilobar Holoprosencephaly
|
0.500 |
Biomarker
|
disease |
CTD_human |
Gas1 is a modifier for holoprosencephaly and genetically interacts with sonic hedgehog.
|
17525797 |
2007 |
|
Lobar Holoprosencephaly
|
0.500 |
GermlineCausalMutation
|
disease |
ORPHANET |
|
|
|
|
Alobar Holoprosencephaly
|
0.500 |
GermlineCausalMutation
|
disease |
ORPHANET |
|
|
|
|
Semilobar Holoprosencephaly
|
0.500 |
GermlineCausalMutation
|
disease |
ORPHANET |
|
|
|
|
Holoprosencephaly
|
0.430 |
GeneticVariation
|
disease |
BEFREE |
Missense substitutions in the GAS1 protein present in holoprosencephaly patients reduce the affinity for its ligand, SHH.
|
21842183 |
2012 |
|
Holoprosencephaly
|
0.430 |
Biomarker
|
disease |
BEFREE |
Clinical manifestations presented by these patients suggest that GAS1 could be considered a candidate locus for one of the types of human HPE.
|
20583177 |
2010 |
|
Holoprosencephaly
|
0.430 |
Biomarker
|
disease |
CTD_human |
Gas1(-/-) mice exhibited microform HPE, including midfacial hypoplasia, premaxillary incisor fusion, and cleft palate, in addition to severe ear defects; however, gross integrity of the forebrain remained intact.
|
17525797 |
2007 |
|
Holoprosencephaly
|
0.430 |
Biomarker
|
disease |
BEFREE |
Gas1(-/-) mice exhibited microform HPE, including midfacial hypoplasia, premaxillary incisor fusion, and cleft palate, in addition to severe ear defects; however, gross integrity of the forebrain remained intact.
|
17525797 |
2007 |
|
Holoprosencephaly
|
0.430 |
Biomarker
|
disease |
HPO |
|
|
|
|
Arhinencephaly
|
0.300 |
Biomarker
|
disease |
CTD_human |
Gas1 is a modifier for holoprosencephaly and genetically interacts with sonic hedgehog.
|
17525797 |
2007 |
|
Cleft Palate
|
0.110 |
Biomarker
|
disease |
BEFREE |
As human GAS1 maps to chromosome 9q21.3-q22, a region previously associated with nonsyndromic cleft palate and congenital deafness, our results establish GAS1 as a potential locus for several human craniofacial malformations.
|
17525797 |
2007 |
|
Cleft Palate
|
0.110 |
Biomarker
|
disease |
HPO |
|
|
|
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Therefore, it is relevant to investigate the potential additive effect of the overexpression of GAS1 and PTEN on tumor growth.
|
29941984 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
On the other hand, several studies have shown the interaction between Gas1 and Hh (Hedgehog) proteins to potentiate the positive regulation of this pathway, which is involved in the development of the nervous system, and in both the origin and progression of different tumors.
|
25429664 |
2014 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
A soluble form of GAS1 inhibits tumor growth and angiogenesis in a triple negative breast cancer model.
|
24992044 |
2014 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Growth arrest specific1 (GAS1) protein is a tumor suppressor that inhibits cancer cell proliferation and induces apoptosis through inhibition of RET receptor tyrosine kinase.
|
24220341 |
2013 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Growth arrest-specific gene 1 is downregulated and inhibits tumor growth in gastric cancer.
|
22846196 |
2012 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The potential of Gas1 as an adjuvant in the treatment of cancer, and its role as a tumor suppressor have also been proposed.
|
19460624 |
2009 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Exogenous IL-11 but not IL-6 activated oncogenic signal transducer and activator of transcription-3, and altered expression of novel proliferative and cytoprotective genes RegIII-beta, RegIII-gamma, gremlin-1, clusterin, and growth arrest specific-1 in wild-type gastric mucosa, a gene signature common in gp130(757F/F) and HKbeta-/- tumors as well as nonneoplastic mucosa of gastric cancer patients.
|
19121317 |
2009 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
We describe here the diagnostic power of a novel 8-genes signature: ornithine decarboxylase (ODC), ornithine decarboxylase antizyme (OAZ), adenosylmethionine decarboxylase (AdoMetDC), spermidine/spermine N(1)-acetyltransferase (SSAT), histone H3 (H3), growth arrest specific gene (GAS1), glyceraldehyde 3-phosphate dehydrogenase (GAPDH) and Clusterin (CLU) in tumour detection/classification of human CaP.
|
18974881 |
2008 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
We further demonstrated that Gas1 has all the expected properties of a melanoma tumor suppressor including: suppression of metastasis in a spontaneous metastasis assay, promotion of apoptosis following dissemination of cells to secondary sites, and frequent down-regulation in human melanoma metastasis-derived cell lines and metastatic tumor samples.
|
18981472 |
2008 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Our results indicate that the targeted expression of tumor suppressor genes (gas1 and p53) regulated by the gfa2 promoter, together with adenoviral vectors may provide an interesting approach for adjuvant selective glioma gene therapy.
|
17599090 |
2007 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Furthermore, retroviral-mediated transfer of gas1 to gliomas implanted in nude mice induces a significant inhibition of tumor growth, accompanied by increased caspase-3 activation.
|
15056455 |
2004 |