Rheumatoid Arthritis
|
0.700 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide meta-analysis reveals shared new loci in systemic seropositive rheumatic diseases.
|
30573655 |
2019 |
Rheumatoid Arthritis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The recent meta-analysis of GWAS has expanded the total number of RA-associated loci to more than 100, out of which approximately ∼97% (98 variants) loci are located in non-coding regions, and the other ∼3% (3 variants) are in three different non-HLA genes, i.e., TYK2 (Prp1104Ala), IL6R (Asp358Ala), and PTPN22 (Trp620Arg).
|
30899276 |
2019 |
Rheumatoid Arthritis
|
0.700 |
GeneticVariation
|
disease |
GWASCAT |
Studying the effects of haplotype partitioning methods on the RA-associated genomic results from the North American Rheumatoid Arthritis Consortium (NARAC) dataset.
|
30891314 |
2019 |
Rheumatoid Arthritis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Results showed that 1858 C/T PTPN22 SNP significantly (P = 0.007, OR = 2.321, 95% CI = 1.063-5.067) associated with RA.
|
31669381 |
2019 |
Rheumatoid Arthritis
|
0.700 |
GeneticVariation
|
disease |
GWASCAT |
Genetic influences on susceptibility to rheumatoid arthritis in African-Americans.
|
30423114 |
2019 |
Rheumatoid Arthritis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Overall, these results showed that the PTPN22 +788 G>A polymorphism is not associated with RA susceptibility in western Mexican population, whereas the presence of G/A genotype is associated with increased PTPN22 mRNA expression in RA patients.
|
30637604 |
2019 |
Rheumatoid Arthritis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
This is the first study of HLA-DRB1 alleles and PTPN22 polymorphism associations with progression to early RA in an Argentinian population.
|
30306282 |
2019 |
Rheumatoid Arthritis
|
0.700 |
Biomarker
|
disease |
BEFREE |
In addition to the long-recognized genetic impact of the HLA locus, interferon regulatory factors, PTPN22, STAT4, and NOX have been implicated in pathogenesis of systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA).
|
30920455 |
2019 |
Rheumatoid Arthritis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
PTPN22 1858C>T polymorphism confers rheumatoid arthritis (RA) susceptibility.
|
30402903 |
2019 |
Rheumatoid Arthritis
|
0.700 |
Biomarker
|
disease |
BEFREE |
Within RA discordant twin pairs PTPN22(T) positive RA twins had a significantly lower amount than their co-twins (-16.3 mtDNA CN).
|
30327147 |
2019 |
Rheumatoid Arthritis
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
More importantly, the in vitro normalization of PTPN22 expression correlates with clinical response to the targeted therapies in a longitudinal RA cohort.
|
31030958 |
2019 |
Rheumatoid Arthritis
|
0.700 |
Biomarker
|
disease |
BEFREE |
Literature was searched using PubMed, EMBASE, Cochrane Library, Korean scientific database, Chinese medical databases, and the Indian medical database to identify eligible studies for determining the association of PTPN22-1123 and RA risk.
|
30957405 |
2019 |
Rheumatoid Arthritis
|
0.700 |
Biomarker
|
disease |
BEFREE |
Similarly, heterozygous (GA) or minor (AA) alleles of <i>PTPN22:rs2476601</i> occurred in 29% RA compared to 6% healthy controls (<i>p</i>-values ≤ 0.05; OR = 5.90).
|
29423382 |
2018 |
Rheumatoid Arthritis
|
0.700 |
Biomarker
|
disease |
BEFREE |
PTPN22 (that encodes a tyrosine phosphatase) has been associated with the development of several autoimmune diseases, including type 1 diabetes, rheumatoid arthritis and systemic lupus erythematosus.
|
29512901 |
2018 |
Rheumatoid Arthritis
|
0.700 |
Biomarker
|
disease |
CTD_human |
Fine-mapping and functional studies highlight potential causal variants for rheumatoid arthritis and type 1 diabetes.
|
30224649 |
2018 |
Rheumatoid Arthritis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
A C1858T single nucleotide polymorphism within PTPN22 (which encodes PTPN22<sup>R620W</sup>) is associated with an enhanced susceptibility to multiple autoimmune diseases including type 1 diabetes and rheumatoid arthritis.
|
30139951 |
2018 |
Rheumatoid Arthritis
|
0.700 |
Biomarker
|
disease |
BEFREE |
Areas covered: This review covers the literature showing how PTPN22 is implicated in signalling pathways involved in the autoimmune and autoinflammatory processes underlying RA.
|
30251905 |
2018 |
Rheumatoid Arthritis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Altogether, we propose a novel mechanism of action of PTPN22 risk allele through the generation of cytotoxic CD4<sup>+</sup> T cells and identify EOMES<sup>+</sup> CD4<sup>+</sup> T cells as a relevant T-cell subset in RA pathogenesis.
|
29388193 |
2018 |
Rheumatoid Arthritis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Meta-analysis by autoimmune disease type showed a significant negative association between the PTPN22 788A allele and systemic lupus erythematous (SLE) (p = 001), rheumatoid arthritis (RA) (p = 0.008), ulcerative colitis (UC) (p = 0.016), but not Crohn's disease (CD).
|
29729713 |
2018 |
Rheumatoid Arthritis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
We also found PTPN22 rs2476601 has no role in susceptibility to RA in Egyptian patients.
|
28424905 |
2017 |
Rheumatoid Arthritis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The GG genotype of PTPN22 rs6665194 (-3508A>G) was associated with significantly reduced risk of RA.
|
28653215 |
2017 |
Rheumatoid Arthritis
|
0.700 |
GeneticVariation
|
disease |
GWASCAT |
A combined large-scale meta-analysis identifies COG6 as a novel shared risk locus for rheumatoid arthritis and systemic lupus erythematosus.
|
27193031 |
2017 |
Rheumatoid Arthritis
|
0.700 |
Biomarker
|
disease |
BEFREE |
Protective Effect of Pinitol Against Inflammatory Mediators of Rheumatoid Arthritis via Inhibition of Protein Tyrosine Phosphatase Non-Receptor Type 22 (PTPN22).
|
28430763 |
2017 |
Rheumatoid Arthritis
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Interestingly, a reduced PTPN22 expression was disclosed in RA patients with ischemic heart disease (p = 0.009).
|
28874816 |
2017 |
Rheumatoid Arthritis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The PTPN22 -1123CC genotype is a protector factor to RA in a Mexican-mestizo population and is associated with low anti-CCP antibodies.
|
28291534 |
2017 |