Autoimmune Diseases
|
0.500 |
GeneticVariation
|
group |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
Autoimmune Diseases
|
0.500 |
GeneticVariation
|
group |
BEFREE |
For Caucasian females, PTPN22 SNP rs2476601 was significantly associated with autoimmune disease by allelic association tests (OR = 1.99, [1.30-3.04]).
|
31759816 |
2019 |
Autoimmune Diseases
|
0.500 |
GeneticVariation
|
group |
BEFREE |
Results set-up the stage for ultimate trials in the treatment of autoimmunity based on the specific inhibitory targeting of C1858T PTPN22 by lipoplexes.
|
30439564 |
2019 |
Autoimmune Diseases
|
0.500 |
GeneticVariation
|
group |
BEFREE |
We synthesized all meta-analyses reporting a genetic association of the PTPN22 1858T C/T polymorphism with autoimmune diseases.
|
30871019 |
2019 |
Autoimmune Diseases
|
0.500 |
GeneticVariation
|
group |
BEFREE |
Our data showed that the PTPN22 R620W polymorphism is a risk factor for TA (CC vs. CT: OR 4.3, p = 0.002, and C vs. T: OR 4.1, p = 0.003); however, the PTPN22 R263Q and - 1123G/C polymorphisms are not associated with this AD.
|
30470857 |
2019 |
Autoimmune Diseases
|
0.500 |
GeneticVariation
|
group |
BEFREE |
A variant in protein tyrosine phosphatase non-receptor type 22 (PTPN22) is associated with reduced risk of developing IBD, but promotes the onset of autoimmune disorders.
|
31107248 |
2019 |
Autoimmune Diseases
|
0.500 |
GeneticVariation
|
group |
BEFREE |
Protein-tyrosine phosphatase nonreceptor type 22 (PTPN22) is a lymphoid-specific tyrosine phosphatase (LYP), and mutations in the <i>PTPN22</i> gene are highly correlated with a spectrum of autoimmune diseases.
|
30979725 |
2019 |
Autoimmune Diseases
|
0.500 |
GeneticVariation
|
group |
BEFREE |
Attenuated T cell receptor (TCR) signalling contributes to the susceptibility for autoimmunity as shown via mutants of PTPN22 and Zap70 genes.
|
29105157 |
2018 |
Autoimmune Diseases
|
0.500 |
Biomarker
|
group |
BEFREE |
These findings highlight PTPN22 as a novel regulator of dectin-1 signals, providing a link between genetically conferred perturbations of innate receptor signaling and the risk of autoimmune disease.
|
28948613 |
2018 |
Autoimmune Diseases
|
0.500 |
Biomarker
|
group |
BEFREE |
Autoimmunity-Associated PTPN22 Polymorphisms in Latent Autoimmune Diabetes of the Adult Differ from Those of Type 1 Diabetes Patients.
|
29895027 |
2018 |
Autoimmune Diseases
|
0.500 |
GeneticVariation
|
group |
BEFREE |
A missense C1858T single nucleotide polymorphism within PTPN22 is a strong genetic risk factor for the development of multiple autoimmune diseases.
|
30054208 |
2018 |
Autoimmune Diseases
|
0.500 |
GeneticVariation
|
group |
BEFREE |
PTPN22 and CTLA-4 polymorphisms are associated with APS and differentiate between polyglandular and monoglandular autoimmunity.
|
29409002 |
2018 |
Autoimmune Diseases
|
0.500 |
GeneticVariation
|
group |
BEFREE |
The presence of the PTPN22 risk allele (1858T) is associated with several autoimmune diseases including rheumatoid arthritis (RA).
|
29388193 |
2018 |
Autoimmune Diseases
|
0.500 |
Biomarker
|
group |
BEFREE |
The indices of glomerular endothelial injuries (EF density and immunopositive area of CD34 and VEGF A) and podocyte injuries (PEP density and immunopositive area of podocyte functional molecules) were also significantly correlated with each other and with indices of autoimmune disease and renal dysfunction.
|
29980767 |
2018 |
Autoimmune Diseases
|
0.500 |
GeneticVariation
|
group |
BEFREE |
This meta-analysis demonstrates that the PTPN22 G788A polymorphism confers protection against SLE, RA, and UC, supporting evidence of association of the PTPN22 gene with a subgroup of autoimmune diseases.
|
29729713 |
2018 |
Autoimmune Diseases
|
0.500 |
Biomarker
|
group |
BEFREE |
We discuss progress in our understanding of the impact of PTPN22 in autoimmune disease in humans and mouse models, as well as recent evidence suggesting that genetic manipulation of PTPN22 expression might enhance the efficacy of anti-tumour T-cell responses.
|
29512901 |
2018 |
Autoimmune Diseases
|
0.500 |
Biomarker
|
group |
BEFREE |
PTPN22 is a known susceptibility gene associated with increased risks of multiple autoimmune diseases.
|
30384852 |
2018 |
Autoimmune Diseases
|
0.500 |
GeneticVariation
|
group |
BEFREE |
The -1123G > C SNP in the PTPN22 gene promoter and HLA DRB1*0405-DQB1*0401 might influence the concurrence of systemic and organ-specific ADs in patients with type 1 diabetes.
|
29762907 |
2018 |
Autoimmune Diseases
|
0.500 |
Biomarker
|
group |
BEFREE |
These findings highlight PTPN22 as a regulator of FcR mediated responses and provide a link between the association of PTPN22<sup>R620W</sup> with autoantibody associated autoimmune diseases.
|
30139951 |
2018 |
Autoimmune Diseases
|
0.500 |
GeneticVariation
|
group |
BEFREE |
The R620W polymorphism in protein tyrosine phosphatase nonreceptor type 22 (PTPN22) predisposes carriers to several autoimmune diseases.
|
29666305 |
2018 |
Autoimmune Diseases
|
0.500 |
Biomarker
|
group |
BEFREE |
Expert commentary: Current data suggest that PTPN22 can be a promising target for therapeutic interventions and identification of at-risk subjects in autoimmune diseases such as T1D.
|
27892782 |
2017 |
Autoimmune Diseases
|
0.500 |
GeneticVariation
|
group |
BEFREE |
PTPN22 C1858T mutation encoding for the R620W lymphoid tyrosine phosphatase variant, plays a potential pathophysiological role in autoimmunity.
|
28437437 |
2017 |
Autoimmune Diseases
|
0.500 |
Biomarker
|
group |
BEFREE |
We show that CD8<sup>+</sup> T cells that lack the tyrosine phosphatase Ptpn22, a major predisposing gene for autoimmune disease, are resistant to the suppressive effects of TGFβ.
|
29116089 |
2017 |
Autoimmune Diseases
|
0.500 |
GeneticVariation
|
group |
BEFREE |
Analysis of PTPN22, ZFAT and MYO9B polymorphisms in Turner Syndrome and risk of autoimmune disease.
|
28627089 |
2017 |
Autoimmune Diseases
|
0.500 |
GeneticVariation
|
group |
BEFREE |
The c.1858C>T polymorphism of the PTPN22 gene, which codes a protein tyrosine phosphatase important in lymphocyte activation, predisposes to a number of autoimmune diseases.
|
27866840 |
2017 |