|
Psoriasis
|
0.190 |
GeneticVariation
|
disease |
BEFREE |
We discovered three significant associations at rs6679677 on 1p13.2 (P=6.15×10<sup>-5</sup> , OR=5.07), rs16861329 on 3q27.3 (P=2.02×10<sup>-4</sup> , OR=0.87) and rs849135 on 7p15.1 (P=6.59×10<sup>-9</sup> , OR=1.78), which suggested PTPN22, ST6GAL1 and JAZF1 as novel susceptibility genes for psoriasis in Chinese population.
|
28603863 |
2017 |
|
Psoriasis
|
0.190 |
GeneticVariation
|
disease |
GWASCAT |
Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci.
|
26974007 |
2016 |
|
Psoriasis
|
0.190 |
GeneticVariation
|
disease |
BEFREE |
For the first time, we report genome-wide significant association of PTPN22 (rs2476601) to PsA susceptibility, but no evidence for association to psoriasis.
|
25923216 |
2015 |
|
Psoriasis
|
0.190 |
GeneticVariation
|
disease |
BEFREE |
The current analysis showed a non-significantly positive association between psoriasis and the PTPN22 T1858 allele, and the association appeared stronger among subjects with psoriatic arthritis.
|
22544573 |
2012 |
|
Psoriasis
|
0.190 |
GeneticVariation
|
disease |
BEFREE |
For example, genetic polymorphisms in the Protein Tyrosine Phosphatase-22 (PTPN22) gene have reproducibly shown to have association with systemic lupus erythematosus (SLE), Graves' disease (GD), rheumatoid arthritis (RA) and multiple sclerosis (MS), but not with psoriasis.
|
22204900 |
2012 |
|
Psoriasis
|
0.190 |
GeneticVariation
|
disease |
BEFREE |
Our results provide evidence that the PTPN22 1858T allele is not a susceptibility factor for PS in the Cretan population.
|
20039785 |
2010 |
|
Psoriasis
|
0.190 |
GeneticVariation
|
disease |
BEFREE |
Thirteen single nucleotide polymorphisms (SNPs) mapping to the PTPN22 region were genotyped in 647 patients with Type I psoriasis and 566 normal controls.
|
18341666 |
2008 |
|
Psoriasis
|
0.190 |
GeneticVariation
|
disease |
LHGDN |
This study demonstrates evidence of association of two SNPs (rs1217414 and rs3789604) in the PTPN22 region with Type I psoriasis, providing evidence for a role of this gene in Type I psoriasis that is not conferred by the R620W variant previously associated with a number of inflammatory diseases.
|
18341666 |
2008 |
|
Psoriasis
|
0.190 |
GeneticVariation
|
disease |
BEFREE |
We exclude a major role of *620W in German psoriasis patients but suggest that other susceptibility determinant(s) within non-coding regions of PTPN22 or its proximity might exist acting independently of the major PSORS1 risk factor.
|
16339849 |
2006 |
|
Psoriasis
|
0.190 |
GeneticVariation
|
disease |
LHGDN |
Protein tyrosine phosphatase gene PTPN22 polymorphism in psoriasis: lack of evidence for association.
|
16098055 |
2005 |
|
Psoriasis
|
0.190 |
GeneticVariation
|
disease |
BEFREE |
The aim of this study was to investigate associations of the missense SNP of PTPN22 in a number of autoimmune diseases in the UK population, including RA, juvenile idiopathic arthritis (JIA), psoriasis, psoriatic arthritis (PsA), and multiple sclerosis (MS), some of which have not been examined previously.
|
15934099 |
2005 |