|
Vitiligo
|
0.180 |
GeneticVariation
|
disease |
BEFREE |
We found that the allelic frequency of variants of PTPN22 (rs2476601) were significantly different between controls and cases showing a vitiligo risk in the South Indian Tamil population.
|
30008646 |
2018 |
|
Vitiligo
|
0.180 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association studies of autoimmune vitiligo identify 23 new risk loci and highlight key pathways and regulatory variants.
|
27723757 |
2016 |
|
Vitiligo
|
0.180 |
GeneticVariation
|
disease |
BEFREE |
Meta-analysis of the PTPN22 1858 C/T polymorphism showed an association between the PTPN22 T allele and vitiligo in all subjects (OR = 1.507, 95 % CI = 1.320-1.720, p < 1.0 × 10(-8)) and in European group (OR = 1.530, 95 % CI = 1.339-1.748, p < 1.0 × 10(-8)), but not in Asians (OR = 0.482, 95 % CI = 0.152-1.530, p = 0.216).
|
23264102 |
2013 |
|
Vitiligo
|
0.180 |
GeneticVariation
|
disease |
GWASDB |
Genome-wide association analyses identify 13 new susceptibility loci for generalized vitiligo.
|
22561518 |
2012 |
|
Vitiligo
|
0.180 |
GeneticVariation
|
disease |
GWASDB |
Genome-wide analysis identifies a quantitative trait locus in the MHC class II region associated with generalized vitiligo age of onset.
|
21326295 |
2011 |
|
Vitiligo
|
0.180 |
GeneticVariation
|
disease |
GWASCAT |
Variant of TYR and autoimmunity susceptibility loci in generalized vitiligo.
|
20410501 |
2010 |
|
Vitiligo
|
0.180 |
GeneticVariation
|
disease |
BEFREE |
In this study, we investigated vitiligo patients in Jordan for patient characteristics and analyzed the association of the 1858C/T (rs2476601, rs2476601" genes_norm="26191">R620W) variant of the PTPN22 gene with vitiligo in our patients.
|
20560680 |
2010 |
|
Vitiligo
|
0.180 |
GeneticVariation
|
disease |
GWASDB |
Variant of TYR and autoimmunity susceptibility loci in generalized vitiligo.
|
20410501 |
2010 |
|
Vitiligo
|
0.180 |
GeneticVariation
|
disease |
BEFREE |
Our results provide evidence that the PTPN22 1858T allele contributes to risk of generalized vitiligo in European Caucasian populations, and underscores the importance of a genetically mediated autoimmune mechanism in the pathogenesis of vitiligo.
|
18426414 |
2008 |
|
Vitiligo
|
0.180 |
Biomarker
|
disease |
LHGDN |
PTPN22 is genetically associated with risk of generalized vitiligo, but CTLA4 is not.
|
18200060 |
2008 |
|
Vitiligo
|
0.180 |
GeneticVariation
|
disease |
LHGDN |
The PTPN22-1858C>T (R620W) functional polymorphism is associated with generalized vitiligo in the Romanian population.
|
18426414 |
2008 |
|
Vitiligo
|
0.180 |
GeneticVariation
|
disease |
BEFREE |
Recently, a gain of function variant C1858T of the lymphoid-specific protein tyrosine phosphatase non-receptor (LYP, PTPN22) gene has been reported to be associated with several autoimmune disorders including Graves' disease, type 1 diabetes, rheumatoid arthritis and vitiligo.
|
16893384 |
2006 |
|
Vitiligo
|
0.180 |
GeneticVariation
|
disease |
BEFREE |
The minor allele of the rs2476601" genes_norm="26191">R620W missense single-nucleotide polymorphism (SNP; rs2476601) in the PTPN22 (protein tyrosine phosphatase non-receptor 22) gene has been reported to be associated with multiple autoimmune diseases, including type 1 diabetes, systemic lupus erythematosus, rheumatoid arthritis, juvenile idiopathic arthritis, autoimmune thyroiditis and vitiligo.
|
16464986 |
2006 |
|
Vitiligo
|
0.180 |
GeneticVariation
|
disease |
BEFREE |
The objective of this study was to ascertain if the disease-associated 1858T allele was also associated with generalised (nonsegmental) vitiligo and so the frequencies of the PTPN22 1858C/T alleles were investigated in 165 English patients with generalised vitiligo and 304 ethnically matched control subjects.
|
16015369 |
2005 |
|
Vitiligo
|
0.180 |
Biomarker
|
disease |
HPO |
|
|
|