PHGDH, phosphoglycerate dehydrogenase, 26227

N. diseases: 288; N. variants: 33
Disease: Breast Carcinoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.500 AlteredExpression disease BEFREE Here, we demonstrate that increased PHGDH expression promotes tumor progression in mouse models of melanoma and breast cancer, human tumor types that exhibit PHGDH copy-number gain. 30905671 2019
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.500 Biomarker disease BEFREE Homo sapiens 3-phosphoglycerate dehydrogenase (PHGDH) catalyzes the first committed step for the synthesis of glucose-derived serine via the phosphoserine pathway and has been associated with a wide variety of cancers, including breast cancer, melanoma, colon cancer, glioma, nasopharyngeal carcinoma, cervical adenocarcinoma, etc. 30852233 2019
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.500 Biomarker disease BEFREE Importantly, we find that PHGDH<sup>high</sup> breast cancer cell lines are exquisitely sensitive to inhibition of the NAD<sup>+</sup> salvage pathway. 30157431 2018
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.500 Biomarker disease BEFREE We have used siRNA-mediated suppression of PHGDH expression to show that PHGDH is a potential therapeutic target in <i>PHGDH</i>-amplified breast cancer. 29568346 2018
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.500 Biomarker disease BEFREE Administration of R11-NLS-pep8 to tumor-bearing mice suppressed tumor growth in the 4T1 breast cancer and the B16 melanoma <i>in vivo</i> models. 29875773 2018
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.500 GeneticVariation disease GWASCAT Association analysis identifies 65 new breast cancer risk loci. 29059683 2017
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.500 Biomarker disease BEFREE TAT-NLS-BLBD-6 commonly down-regulated 27 candidate genes in MCF-7 and MDA-MB-231 cells, which are concurrent with Wnt downstream target genes in human breast cancer. 26750754 2016
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.500 Biomarker disease BEFREE However, PHGDH knockdown does not affect tumor maintenance and growth in established breast cancer xenograft models, suggesting that PHGDH-dependent cancer cell growth may be context-dependent. 24318446 2013
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.500 Biomarker disease BEFREE Recent evidence has shown that PHGDH is amplified in human breast cancer and melanoma and plays a key role in cancer metabolism. 23229761 2013
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.500 Biomarker disease BEFREE PHGDH catalyses the first step in the serine biosynthesis pathway, and breast cancer cells with high PHGDH expression have increased serine synthesis flux. 21760589 2011
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.500 AlteredExpression disease BEFREE High expression of PHGDH and PSAT1 in primary breast cancer was significantly associated with decreased relapse-free and overall survival of patients and malignant phenotypic features of breast cancer. 20352489 2011
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.500 AlteredExpression disease BEFREE Increased expression was also associated with breast cancer subtypes, and ectopic expression of PHGDH in mammary epithelial cells disrupted acinar morphogenesis and induced other phenotypic alterations that may predispose cells to transformation. 21804546 2011
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.500 Biomarker disease CTD_human Increased expression was also associated with breast cancer subtypes, and ectopic expression of PHGDH in mammary epithelial cells disrupted acinar morphogenesis and induced other phenotypic alterations that may predispose cells to transformation. 21804546 2011