GATA2, GATA binding protein 2, 2624

N. diseases: 229; N. variants: 33
Disease: Childhood Leukemia ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1332977
Disease: Childhood Leukemia
Childhood Leukemia 		0.080 AlteredExpression disease BEFREE In summary, reduction of Gata2 activity affects mutational dynamics of leukemia with delayed leukemia onset in Cbfb-MYH11 knockin mice, but paradoxically results in a more aggressive leukemia phenotype, which may be correlated with leukemia relapse or poor prognosis in human patients. 31624376 2020
CUI: C1332977
Disease: Childhood Leukemia
Childhood Leukemia 		0.080 GeneticVariation disease BEFREE GATA-2 mutations are associated with immunodeficiency, lymphedema, myelodysplastic syndrome (MDS), and leukemia. 28566565 2017
CUI: C1332977
Disease: Childhood Leukemia
Childhood Leukemia 		0.080 GeneticVariation disease BEFREE Hematopoietic development requires the transcription factor GATA-2, and GATA-2 mutations cause diverse pathologies, including leukemia. 28930689 2017
CUI: C1332977
Disease: Childhood Leukemia
Childhood Leukemia 		0.080 GeneticVariation disease BEFREE GATA2 mutations are associated with several conditions, including Emberger syndrome which is the association of primary lymphedema with hematological anomalies and an increased risk for myelodysplasia and leukemia. 28271814 2017
CUI: C1332977
Disease: Childhood Leukemia
Childhood Leukemia 		0.080 GeneticVariation disease BEFREE Transcription factor gene GATA2: Association of leukemia and nonsynonymous to the synonymous substitution rate across five mammals. 26850985 2016
CUI: C1332977
Disease: Childhood Leukemia
Childhood Leukemia 		0.080 Biomarker disease BEFREE A single oncogenic enhancer rearrangement causes concomitant EVI1 and GATA2 deregulation in leukemia. 24703711 2014
CUI: C1332977
Disease: Childhood Leukemia
Childhood Leukemia 		0.080 Biomarker disease BEFREE Mutations in the master regulator of hematopoiesis GATA-2 underlie an immunodeficiency associated with myelodysplastic syndrome and leukemia. 25056917 2014
CUI: C1332977
Disease: Childhood Leukemia
Childhood Leukemia 		0.080 AlteredExpression disease BEFREE We found a significant correlation among the amounts of WT1, GATA-1 and GATA-2 mRNAs from leukemia and solid tumor cell lines. 19212333 2009