GATA4, GATA binding protein 4, 2626

N. diseases: 336; N. variants: 72
Disease: Heart Diseases ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0018799
Disease: Heart Diseases
Heart Diseases 		0.080 GeneticVariation group BEFREE Our observations demonstrate that cGMP-PKG signaling mediates transcriptional activity of GATA4 and links defective GATA4 and PKG-1α mutations to the development of human heart disease. 26946174 2016
CUI: C0018799
Disease: Heart Diseases
Heart Diseases 		0.080 Biomarker group BEFREE The finding that postnatal upregulation of a cell-cycle gene in GATA4 haplo-insufficient hearts may be protective opens new avenues for maintaining or restoring cardiac function in GATA4-dependent cardiac disease. 22923619 2012
CUI: C0018799
Disease: Heart Diseases
Heart Diseases 		0.080 GeneticVariation group BEFREE Mutations in GATA4, the mammalian homolog of pnr, have also been implicated in causing human cardiac disease in a haploinsufficient manner. 19494035 2009
CUI: C0018799
Disease: Heart Diseases
Heart Diseases 		0.080 GeneticVariation group LHGDN GATA4 mutations in 486 Chinese patients with congenital heart disease. 18672102 2009
CUI: C0018799
Disease: Heart Diseases
Heart Diseases 		0.080 GeneticVariation group BEFREE Spectrum of heart disease associated with murine and human GATA4 mutation. 17643447 2007
CUI: C0018799
Disease: Heart Diseases
Heart Diseases 		0.080 GeneticVariation group LHGDN Mutations in the 3'-untranslated region of GATA4 as molecular hotspots for congenital heart disease (CHD). 17592645 2007
CUI: C0018799
Disease: Heart Diseases
Heart Diseases 		0.080 GeneticVariation group LHGDN Screening and biochemical analysis of GATA4 sequence variations identified in patients with congenital heart disease. 17352393 2007
CUI: C0018799
Disease: Heart Diseases
Heart Diseases 		0.080 GeneticVariation group LHGDN Screening of 99 Danish patients with congenital heart disease for GATA4 mutations. 17253934 2006