GATA6, GATA binding protein 6, 2627

N. diseases: 259; N. variants: 21
Disease: Pyelonephritis ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0034186
Disease: Pyelonephritis
Pyelonephritis 		0.010 Biomarker disease BEFREE In mice deficient in GATA6+ peritoneal macrophages, neutrophils infiltrated more robustly and reduced S. aureus dissemination.Antibiotics administered i.v. did not prevent dissemination into the peritoneum or to the kidneys, whereas peritoneal administration of vancomycin (particularly liposomal vancomycin with optimized intracellular penetrance capacity) reduced kidney infection and mortality, even when administered 24 hours after infection. 31545300 2019