|
Parkinson Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Mechanisms by which fibroblast growth factor 20 improves motor performance in a mouse model of Parkinson's disease.
|
30964070 |
2019 |
|
Parkinson Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Previous studies have demonstrated that FGF20 enhances the survival of dopaminergic neurons suggesting the potential use of FGF20 to treat Parkinson's disease (PD).
|
30043675 |
2018 |
|
Parkinson Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our results suggest that FGF 20 is a susceptibility gene for PD in Eastern Indians.
|
29604408 |
2018 |
|
Parkinson Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Boosting the endogenous FGF20 production might offer potential as a future therapeutic strategy in Parkinson's disease.
|
29698669 |
2018 |
|
Parkinson Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The pooled odds ratios (OR) and 95% confidence interval (CI) were calculated to assess the association between FGF20 rs12720208 polymorphism and PD risk.
|
28191856 |
2017 |
|
Parkinson Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our study is the first to demonstrate that FGF20 (rs591323) is associated with a lower risk of PD in a Southern Han Chinese population from mainland China.
|
28238162 |
2017 |
|
Parkinson Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Variants in the fibroblast growth factor 20 gene (FGF20) have been reported to be associated with the risk of Parkinson's disease.
|
27040428 |
2016 |
|
Parkinson Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The pooled odds ratio (OR) with its 95 % confidence interval (CI) was calculated to assess the genetic association between FGF20 rs12720208 polymorphism and the risk of PD.
|
27023076 |
2016 |
|
Parkinson Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Variation in the miRNA-433 binding site of FGF20 is a risk factor for Parkinson's disease in Iranian population.
|
26070653 |
2015 |
|
Parkinson Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
To evaluate the relationships among 3 polymorphic markers located in the fibroblast growth factor 20 and transmembrane protein 175 genes and the genetic susceptibility to PD in northern Chinese subjects, 2 single nucleotide polymorphisms, and 1 insertion/deletion marker (rs591323 in FGF20; rs6599388 and rs142821586 in transmembrane protein 175 near the G-associated kinase/diacylglycerol kinase theta region) were investigated in 313 PD patients and 318 matched controls.
|
26535683 |
2015 |
|
Parkinson Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The meta-analysis showed an association between FGF20 gene rs1721100 polymorphism and risk of Parkinson's disease under a recessive model (GG versus CG+GG; OR = 1.15, 95 % CI 1.02-1.29, p = 0.02) but not under a dominant model (CG+GG versus CC; OR = 1.03, 95 % CI 0.93-1.13, p = 0.57).
|
24942208 |
2014 |
|
Parkinson Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
This indicates the FGF20 gene might not play a major role in the genetic predisposition to PD in this population.
|
23938014 |
2013 |
|
Parkinson Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Genetic variation in fibroblast growth factor 20 (FGF20) might influence the risk of PD occurrence and development.
|
22342445 |
2012 |
|
Parkinson Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
FGF20 rs12720208 SNP and microRNA-433 variation: no association with Parkinson's disease in Spanish patients.
|
20471450 |
2010 |
|
Parkinson Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We explored the effect of single-nucleotide polymorphisms (SNPs) in the fibroblast growth factor 20 gene (FGF20) associated with risk for Parkinson's disease on brain structure and function in a large sample of healthy young-adult human subjects and also in elderly subjects to look at the interaction between genetic variations and age (N = 237; 116 men; 18-87 years).
|
20427658 |
2010 |
|
Parkinson Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We found no evidence of association between FGF20 variability and PD risk, and no relationship between the rs12720208 genotype, FGF20 and alpha-synuclein protein levels.
|
19133659 |
2009 |
|
Parkinson Disease
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
These include FGF3 in Michel aplasia; FGF8 in cleft lip/palate and in hypogonadotropic hypogonadism; FGF9 in carcinoma; FGF10 in the lacrimal/salivary glands aplasia, and lacrimo-auriculo-dento-digital syndrome; FGF14 in spinocerebellar ataxia; FGF20 in Parkinson disease; and FGF23 in tumoral calcinosis and hypophosphatemic rickets.
|
19621416 |
2009 |
|
Parkinson Disease
|
0.100 |
GeneticVariation
|
disease |
LHGDN |
In a cell-based system and in PD brains, this increase in translation of FGF20 is correlated with increased alpha-synuclein expression, which has previously been shown to cause PD through both overexpression and point mutations.
|
18252210 |
2008 |
|
Parkinson Disease
|
0.100 |
Biomarker
|
disease |
LHGDN |
We also replicated the association of fibroblast growth factor 20 (FGF20) with PD (P = 0.0089).
|
18568448 |
2008 |
|
Parkinson Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, variants in FGF20 and MAOB show evidence of statistical interactions, which emphasizes the importance of considering them jointly in genetic analysis of PD and illustrates potential patterns of biological interaction contributing to PD risk.
|
18205889 |
2008 |
|
Parkinson Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
In a cell-based system and in PD brains, this increase in translation of FGF20 is correlated with increased alpha-synuclein expression, which has previously been shown to cause PD through both overexpression and point mutations.
|
18252210 |
2008 |
|
Parkinson Disease
|
0.100 |
GeneticVariation
|
disease |
LHGDN |
In conclusion, variants in FGF20 and MAOB show evidence of statistical interactions, which emphasizes the importance of considering them jointly in genetic analysis of PD and illustrates potential patterns of biological interaction contributing to PD risk.
|
18205889 |
2008 |
|
Parkinson Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
We also replicated the association of fibroblast growth factor 20 (FGF20) with PD (P = 0.0089).
|
18568448 |
2008 |
|
Parkinson Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
These results suggest that the FGF20 gene is a susceptibility gene for Parkinson's disease in the Japanese population.
|
17515805 |
2007 |
|
Parkinson Disease
|
0.100 |
Biomarker
|
disease |
LHGDN |
These results suggest that the FGF20 gene is a susceptibility gene for Parkinson's disease in the Japanese population.
|
17515805 |
2007 |