GBA, glucosylceramidase beta, 2629

N. diseases: 319; N. variants: 157
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1332979
Disease: Childhood Lymphoma
Childhood Lymphoma
0.050 Biomarker disease BEFREE Here, we show that UCH-L1 reflects GC lineage in lymphoma and is an oncogenic biomarker of aggressive GCB-DLBCL. 26702068 2016
CUI: C1332979
Disease: Childhood Lymphoma
Childhood Lymphoma
0.050 Biomarker disease BEFREE Diffuse large B-cell lymphoma (DLBCL) is the most common lymphoma and can be separated into two subtypes based upon molecular features with similarities to germinal centre B-cells (GCB-like) or activated B-cells (ABC-like). 24887457 2014
CUI: C1332979
Disease: Childhood Lymphoma
Childhood Lymphoma
0.050 Biomarker disease BEFREE Gα13-deficient mouse germinal centre B cells and human GCB-DLBCL cells were unable to suppress pAkt and migration in response to S1P, and Gα13-deficient mice developed germinal centre B-cell-derived lymphoma. 25274307 2014
CUI: C1332979
Disease: Childhood Lymphoma
Childhood Lymphoma
0.050 AlteredExpression disease BEFREE Here, we identified candidate genes which were upregulated after an epigenetic treatment of B-cell lymphoma cell lines (Burkitt's lymphoma, BL; Follicular lymphoma, FL; Diffuse large B-cell lymphoma, DLBCL activated B-cell like, ABC; and germinal center like, GCB) and simultaneously expressed at low levels in samples from lymphoma patients. 25226156 2014
CUI: C1332979
Disease: Childhood Lymphoma
Childhood Lymphoma
0.050 GeneticVariation disease BEFREE EZH2 mutations were frequently associated with the presence of BCL2 rearrangement (BCL2-R) in both the FL (28% of BCL-R cases versus 0% of BCL2-WT cases, p<0.05) and GCB-DLBCL groups (33% of BCL2-R cases versus 4% of BCL2-WT cases, p<0.04), and across all lymphoma types excluding BL (27% of BCL2-R cases versus 3% of BCL2-WT cases, p<0.003). 22194861 2011