FGF21, fibroblast growth factor 21, 26291

N. diseases: 236; N. variants: 2
Disease: Kidney Failure ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0035078
Disease: Kidney Failure
Kidney Failure 		0.020 GeneticVariation disease BEFREE In this study, we developed gene therapies based on 3 longevity associated genes (fibroblast growth factor 21 [FGF21], αKlotho, soluble form of mouse transforming growth factor-β receptor 2 [sTGFβR2]) delivered using adeno-associated viruses and explored their ability to mitigate 4 age-related diseases: obesity, type II diabetes, heart failure, and renal failure. 31685628 2019
CUI: C0035078
Disease: Kidney Failure
Kidney Failure 		0.020 Biomarker disease BEFREE In diabetes mellitus, FGF21 predicted disease incidence or progression (HR: 1.35, 95% CI: 1.06-1.72, P < 0.05, I<sup>2</sup> = 69%) and worsening renal failure (HR: 1.06, 95% CI: 1.03-1.09, P < 0.0001, I<sup>2</sup> = 47%). 29410351 2018