GCG, glucagon, 2641

N. diseases: 441; N. variants: 10
Disease: Pain ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0030193
Disease: Pain
Pain 		0.040 Biomarker phenotype BEFREE Glucagon-like peptide-1 (GLP-1) is beneficial in relieving pain-related symptoms of Irritable bowel syndrome (IBS), a prevalent, multi-factorial functional bowel disorder characterized by diarrhea and/or constipation, abdominal bloating, and pain. 31602785 2020
CUI: C0030193
Disease: Pain
Pain 		0.040 Biomarker phenotype BEFREE The involvement of opioid receptor (OR) subtypes, Y1-, and GLP1 receptors were also investigated.In CFA pain model it. diprotin A or vildagliptin dose-dependently inhibits hyperalgesia in ipsilateral while has no effect in contralateral paws. 30738866 2019
CUI: C0030193
Disease: Pain
Pain 		0.040 Biomarker phenotype BEFREE GLP-1 (0.2 mg/kg) and GLP-2 (0.05, 0.2 mg/kg) significantly increased pain threshold. 30607480 2019
CUI: C0030193
Disease: Pain
Pain 		0.040 Biomarker phenotype BEFREE Activation of spinal glucagon-like peptide-1 receptors specifically suppresses pain hypersensitivity. 24719110 2014