GCKR, glucokinase regulator, 2646

N. diseases: 136; N. variants: 23
Disease: Fatty Liver ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0015695
Disease: Fatty Liver
Fatty Liver 		0.060 GeneticVariation disease BEFREE Metabolic effects of LYPLAL1 rs12137855-C were similar, but statistically less robust, to the effects of GCKR rs1260326-T. TM6SF2 rs58542926-T displayed opposite metabolic effects when compared with the fatty liver associations. 29648650 2018
CUI: C0015695
Disease: Fatty Liver
Fatty Liver 		0.060 GeneticVariation disease BEFREE PNPLA3 rs738409, GCKR rs780094 and TM6SF2 rs58542926 variants were independent risk factors of hepatic steatosis and elevated ALT levels. 29314568 2018
CUI: C0015695
Disease: Fatty Liver
Fatty Liver 		0.060 GeneticVariation disease BEFREE We determined the frequency of PNPLA3 (rs738409), CSPG3/NCAN (rs2228603), GCKR (rs780094), PPP1R3B (rs4240624), TM6SF (rs8542926), LYPLAL1 (rs12137855) and MBOAT7 (rs626283) by RT-PCR in 117 HIV-positive patients on cART and stratified participants based on their "controlled attenuation parameter" (CAP) into probable (CAP: 215-300 dB/m) and definite (CAP >300 dB/m) hepatic steatosis. 28594920 2017
CUI: C0015695
Disease: Fatty Liver
Fatty Liver 		0.060 GeneticVariation disease BEFREE Variant in glucokinase regulatory protein (GCKR), associated with lipid and glucose traits, has been suggested to affect fatty liver infiltration. 24498332 2014
CUI: C0015695
Disease: Fatty Liver
Fatty Liver 		0.060 GeneticVariation disease BEFREE The importance of GCKR in this protective mechanism is supported by "less-active" GCKR variants in association not only with hepatic steatosis and hyperuricaemia but also with lower fasting plasma glucose and decreased insulin resistance. 23022226 2013
CUI: C0015695
Disease: Fatty Liver
Fatty Liver 		0.060 Biomarker disease BEFREE GCKR and PNPLA3 act together to convey susceptibility to fatty liver in obese youths. 22105854 2012