|
Hypertriglyceridemia
|
0.490 |
GeneticVariation
|
phenotype |
BEFREE |
Gene-centric analysis revealed burden of variants for increasing HTG risk in GCKR (p = 2.1x10-5), LPL (p = 1.6x10-3) and MLXIPL (p = 1.6x10-2) genes.
|
31369557 |
2019 |
|
Hypertriglyceridemia
|
0.490 |
GeneticVariation
|
phenotype |
BEFREE |
In the dominant inheritance model, we identified probands harboring deleterious heterozygous variants in LPL, glucokinase regulatory protein, and solute carrier family 25 member 40 genes, possibly associated with this extreme HTG phenotype.
|
30389453 |
2019 |
|
Hypertriglyceridemia
|
0.490 |
Biomarker
|
phenotype |
BEFREE |
GCKR was associated with protection against type 2 diabetes (T2D) in MAs, and with hypertriglyceridemia and protection against low HDL Cholesterol (HDL-C) levels in MEZs.
|
30176313 |
2018 |
|
Hypertriglyceridemia
|
0.490 |
GeneticVariation
|
phenotype |
GWASCAT |
A common variant association study in ethnic Saudi Arabs reveals novel susceptibility loci for hypertriglyceridemia.
|
27599772 |
2017 |
|
Hypertriglyceridemia
|
0.490 |
GeneticVariation
|
phenotype |
BEFREE |
Once demographics, medication use and baseline adiposity, and fitness were accounted for, ILI did not modify the baseline association of GCKR-Leu446Pro with elevated triglycerides (β±SE=0.067±0.013, P=1.5×10(-7) and β±SE=0.052±0.015, P=5×10(-4)) or with elevated CRP (β±SE=0.136±0.034, P=5.1×10(-5)and β±SE=0.903±0.038, P=0.015) in the overall sample and Non-Hispanic Whites, respectively.
|
26578543 |
2016 |
|
Hypertriglyceridemia
|
0.490 |
GeneticVariation
|
phenotype |
BEFREE |
The T2D risk alleles of rs972283 near KLF14 and rs11634397 near ZFAND6 were associated with a higher risk for elevated triglycerides (rs972283: 1.11 (1.02, 1.24), P = 1.46 × 10-2; rs11634397: 1.14 (1.00, 1.29), P = 4.66 × 10-2), while the T2D risk alleles of rs780094 in GCKR and rs7903146 in TCF7L2 were related to a lower risk of elevated triglycerides (rs780094: 0.86 (0.80, 0.93), P = 1.35 × 10-4; rs7903146: 0.82 (0.69, 0.98), P = 3.18 × 10-2).
|
26599349 |
2015 |
|
Hypertriglyceridemia
|
0.490 |
AlteredExpression
|
phenotype |
BEFREE |
Common genetic variants found in LPL, APOA5, and GCKR are associated with triglycerides levels in patients with primary hypertriglyceridemias.
|
25176936 |
2014 |
|
Hypertriglyceridemia
|
0.490 |
GeneticVariation
|
phenotype |
BEFREE |
GCKR rs780094 was also associated with decreased plasma glucose, and increased triglycerides in the patient and control groups.
|
24785259 |
2014 |
|
Hypertriglyceridemia
|
0.490 |
GeneticVariation
|
phenotype |
GWASDB |
Genomic study in Mexicans identifies a new locus for triglycerides and refines European lipid loci.
|
23505323 |
2013 |
|
Hypertriglyceridemia
|
0.490 |
GeneticVariation
|
phenotype |
BEFREE |
Recently, the single nucleotide polymorphism (SNP) identified as rs1260326, in the glucokinase regulatory protein (GCKR), was associated with hypertriglyceridemia in adults.
|
22105854 |
2012 |
|
Hypertriglyceridemia
|
0.490 |
GeneticVariation
|
phenotype |
GWASCAT |
Through GWAS, we identified common variants in APOA5, GCKR, LPL and APOB associated with HTG.
|
20657596 |
2010 |
|
Hypertriglyceridemia
|
0.490 |
Biomarker
|
phenotype |
CTD_human |
Through GWAS, we identified common variants in APOA5, GCKR, LPL and APOB associated with HTG.
|
20657596 |
2010 |
|
Hypertriglyceridemia
|
0.490 |
GeneticVariation
|
phenotype |
BEFREE |
Through GWAS, we identified common variants in APOA5, GCKR, LPL and APOB associated with HTG.
|
20657596 |
2010 |
|
Hypertriglyceridemia
|
0.490 |
GeneticVariation
|
phenotype |
GWASDB |
Through GWAS, we identified common variants in APOA5, GCKR, LPL and APOB associated with HTG.
|
20657596 |
2010 |