GCKR, glucokinase regulator, 2646

N. diseases: 136; N. variants: 23
Disease: Obesity ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0028754
Disease: Obesity
Obesity 		0.090 GeneticVariation disease BEFREE Ga allele of GCKR (rs780094) SNPs had a protective effect on obesity. 29531563 2018
CUI: C0028754
Disease: Obesity
Obesity 		0.090 Biomarker disease BEFREE GKRP deacetylation-mimicking mutants dissociate from glucokinase in a glucose concentration-dependent manner in obese diabetic mouse-derived hepatocytes and increase HGU and glucose tolerance in HFD-induced or db/db obese diabetic mice. 29296001 2018
CUI: C0028754
Disease: Obesity
Obesity 		0.090 GeneticVariation disease BEFREE Here we show that adiposity significantly amplifies the effect of three sequence variants (encoding PNPLA3 p.I148M, TM6SF2 p.E167K, and GCKR p.P446L) associated with nonalcoholic fatty liver disease (NAFLD). 28436986 2017
CUI: C0028754
Disease: Obesity
Obesity 		0.090 Biomarker disease BEFREE Moderate improvements in adiposity and fitness with ILI did not mitigate the adverse cardiometabolic effects of GCKR inhibition in overweight/obese individuals with diabetes mellitus. 26578543 2016
CUI: C0028754
Disease: Obesity
Obesity 		0.090 Biomarker disease BEFREE Hepatic De Novo Lipogenesis in Obese Youth Is Modulated by a Common Variant in the GCKR Gene. 26043229 2015
CUI: C0028754
Disease: Obesity
Obesity 		0.090 GeneticVariation disease BEFREE Results of logistic regression revealed that, despite higher triglyceride levels, the carriers of the GCKR variants were more protected against the development of obesity; the adjusted models confirmed the lower risk of obesity for both variants (rs1260326: OR, 0.46; 95% CI, 0.25-0.83; rs780094: OR, 0.41; 95% CI, 0.23-0.74). 21511510 2011
CUI: C0028754
Disease: Obesity
Obesity 		0.090 GeneticVariation disease BEFREE There is evidence that obesity and obesity-related phenotypes are associated with variations in several genes, including NEGR1, SEC16B, TMEM18, ETV5, GNPDA2, BDNF, MTCH2, SH2B1, FTO, MAF, MC4R, KCTD15, SCG3, MTMR9, TFAP2B, MSRA, LYPLAL1, GCKR and FADS1. 21796137 2011
CUI: C0028754
Disease: Obesity
Obesity 		0.090 GeneticVariation disease BEFREE The GCKR rs780094 was also associated with obesity and BMI, independently of its association with type 2 diabetes. 19241058 2009
CUI: C0028754
Disease: Obesity
Obesity 		0.090 GeneticVariation disease BEFREE Mutations were sought in the GKRP gene of 57 patients from the families of the French genome-wide scan for obesity that contributed most to the positive LOD score with 2p21-23. 12739015 2003