|
Dyslipidemias
|
0.090 |
GeneticVariation
|
group |
BEFREE |
Targeted sequencing of candidate genes of dyslipidemia in Punjabi Sikhs: Population-specific rare variants in GCKR promote ectopic fat deposition.
|
31369557 |
2019 |
|
Dyslipidemias
|
0.090 |
GeneticVariation
|
group |
BEFREE |
The results of this population-based study provide evidence for a relationship between lipid regulatory gene polymorphisms including GCKR (rs780094), GCKR (rs1260333), FADS (rs174547), and MLXIPL (rs3812316) with dyslipidemia in an Iranian population.
|
29858861 |
2018 |
|
Dyslipidemias
|
0.090 |
GeneticVariation
|
group |
BEFREE |
Recently, genome-wide association studies (GWASs) have shown that variants in the gene encoding GKRP protect against T2DM and kidney disease but predispose to gout, nonalcoholic fatty liver disease, and dyslipidemia.
|
26432016 |
2015 |
|
Dyslipidemias
|
0.090 |
Biomarker
|
group |
BEFREE |
Our cross-sectional study confirmed the essential roles of the polymorphisms of the APOA5, GCK and GCKR in the lipid or glucose metabolism disorders, and suggested the importance of fat intake control in the individualized prevention of dyslipidemia.
|
22517333 |
2012 |
|
Dyslipidemias
|
0.090 |
GeneticVariation
|
group |
BEFREE |
Several studies have shown that variants in the glucokinase regulatory protein gene (GCKR) were associated with type 2 diabetes and dyslipidemia.
|
21569451 |
2011 |
|
Dyslipidemias
|
0.090 |
GeneticVariation
|
group |
BEFREE |
Consistent with observations in white Europeans, the GCKR rs780094 polymorphism contributes to the risk of type 2 diabetes and dyslipidaemia in Han Chinese individuals.
|
19241058 |
2009 |
|
Dyslipidemias
|
0.090 |
GeneticVariation
|
group |
LHGDN |
GCKR-L446 carriers are protected against type 2 diabetes despite higher triglyceride levels and risk of dyslipidemia, which suggests a potential molecular mechanism by which these two components of the metabolic syndrome can be dissociated.
|
18556336 |
2008 |
|
Dyslipidemias
|
0.090 |
GeneticVariation
|
group |
BEFREE |
A polymorphism in the GCKR gene predicted dyslipidaemia (rs1260326, OR 1.15, 95% CI 1.09-1.22, p < 0.00001) but not the metabolic syndrome.
|
18853134 |
2008 |
|
Dyslipidemias
|
0.090 |
GeneticVariation
|
group |
BEFREE |
GCKR-L446 carriers are protected against type 2 diabetes despite higher triglyceride levels and risk of dyslipidemia, which suggests a potential molecular mechanism by which these two components of the metabolic syndrome can be dissociated.
|
18556336 |
2008 |
|
Dyslipidemias
|
0.090 |
GeneticVariation
|
group |
BEFREE |
The minor GCKR A-allele of rs780094 is associated with an increased level of fasting serum triacylglycerol (p = 6 x 10(-14)), impaired fasting (p = 0.001) and OGTT-related insulin release (p = 3 x 10(-6)), reduced homeostasis model assessment of insulin resistance (p = 0.0004), WHO-defined dyslipidaemia (p = 6 x 10(-9)) and a modestly decreased risk of type 2 diabetes (p = 0.01).
|
18008060 |
2008 |