|
POLYPOSIS SYNDROME, HEREDITARY MIXED, 1
|
0.610 |
Biomarker
|
disease |
CLINGEN |
GREM1 and POLE variants in hereditary colorectal cancer syndromes.
|
26493165 |
2016 |
|
POLYPOSIS SYNDROME, HEREDITARY MIXED, 1
|
0.610 |
Biomarker
|
disease |
CLINGEN |
GREM1 germline mutation screening in Ashkenazi Jewish patients with familial colorectal cancer.
|
25992589 |
2015 |
|
POLYPOSIS SYNDROME, HEREDITARY MIXED, 1
|
0.610 |
Biomarker
|
disease |
CLINGEN |
Aberrant epithelial GREM1 expression initiates colonic tumorigenesis from cells outside the stem cell niche.
|
25419707 |
2015 |
|
POLYPOSIS SYNDROME, HEREDITARY MIXED, 1
|
0.610 |
GermlineCausalMutation
|
disease |
ORPHANET |
Hereditary mixed polyposis syndrome is caused by a 40-kb upstream duplication that leads to increased and ectopic expression of the BMP antagonist GREM1.
|
22561515 |
2012 |
|
POLYPOSIS SYNDROME, HEREDITARY MIXED, 1
|
0.610 |
Biomarker
|
disease |
CLINGEN |
Hereditary mixed polyposis syndrome is caused by a 40-kb upstream duplication that leads to increased and ectopic expression of the BMP antagonist GREM1.
|
22561515 |
2012 |
|
POLYPOSIS SYNDROME, HEREDITARY MIXED, 1
|
0.610 |
Biomarker
|
disease |
CLINGEN |
Identification of candidate predisposing copy number variants in familial and early-onset colorectal cancer patients.
|
21128281 |
2011 |
|
POLYPOSIS SYNDROME, HEREDITARY MIXED, 1
|
0.610 |
GeneticVariation
|
disease |
BEFREE |
Common genetic variants at the CRAC1 (HMPS) locus on chromosome 15q13.3 influence colorectal cancer risk.
|
18084292 |
2008 |
|
POLYPOSIS SYNDROME, HEREDITARY MIXED, 1
|
0.610 |
Biomarker
|
disease |
CLINGEN |
Gene expression patterns of human colon tops and basal crypts and BMP antagonists as intestinal stem cell niche factors.
|
17881565 |
2007 |
|
POLYPOSIS SYNDROME, HEREDITARY MIXED, 1
|
0.610 |
Biomarker
|
disease |
CLINGEN |
The bone morphogenetic protein antagonist gremlin 1 is overexpressed in human cancers and interacts with YWHAH protein.
|
16545136 |
2006 |
|
POLYPOSIS SYNDROME, HEREDITARY MIXED, 1
|
0.610 |
Biomarker
|
disease |
CLINGEN |
An ancestral Ashkenazi haplotype at the HMPS/CRAC1 locus on 15q13-q14 is associated with hereditary mixed polyposis syndrome.
|
12696020 |
2003 |
|
POLYPOSIS SYNDROME, HEREDITARY MIXED, 1
|
0.610 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
|
|
|
|
POLYPOSIS SYNDROME, HEREDITARY MIXED, 1
|
0.610 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
|
|
|
|
Colorectal Carcinoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
Hence, these experiments demonstrated that GREM1 is involved in CRC development and procession and provide a new idea for CRC diagnosis, resistance therapy, and prognosis.
|
30426548 |
2019 |
|
Colorectal Carcinoma
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Association analyses identify 31 new risk loci for colorectal cancer susceptibility.
|
31089142 |
2019 |
|
Colorectal Carcinoma
|
0.500 |
Biomarker
|
disease |
CTD_human |
Discovery of common and rare genetic risk variants for colorectal cancer.
|
30510241 |
2019 |
|
Colorectal Carcinoma
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Discovery of common and rare genetic risk variants for colorectal cancer.
|
30510241 |
2019 |
|
Colorectal Carcinoma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We provide an overview of newly described genes and syndromes associated with predisposition to CRC and polyposis, including: polymerase proofreading-associated polyposis, NTHL1-associated polyposis, mismatch repair gene biallelic inactivation-related adenomatous polyposis (including MSH3- and MLH3-associated polyposes), GREM1-associated mixed polyposis, RNF43-associated serrated polyposis, and RPS20 mutations as a rare cause of hereditary nonpolyposis CRC.
|
30862463 |
2019 |
|
Colorectal Carcinoma
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Novel Common Genetic Susceptibility Loci for Colorectal Cancer.
|
29917119 |
2019 |
|
Colorectal Carcinoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
In total, 44% of CRCs were positive for stromal GREM1, which was associated with decreased lymphovascular invasion, a lower cancer stage, and nuclear β-catenin staining.
|
28041973 |
2017 |
|
Colorectal Carcinoma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, low-frequency UTR variant rs12915554 in the gene GREM1 was in relation to CRC susceptibility in a Chinese population and this variation might promote CRC development through enhancing GREM1 expression in a miRNA-mediated posttranscriptional manner.
|
28977865 |
2017 |
|
Colorectal Carcinoma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We report 4 extended families with the duplication near GREM1 previously found in Ashkenazi Jews; 3 families were identified at cancer genetic clinics in Israel and 1 family was identified in a cohort of patients with familial colorectal cancer.
|
28242209 |
2017 |
|
Colorectal Carcinoma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In conclusion a high penetrant duplication in the regulatory region of GREM1, predisposing to CRC, was identified in a family with attenuated/atypical polyposis.
|
26493165 |
2016 |
|
Colorectal Carcinoma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Most of the approximately 13 high-penetrance genes that predispose to CRC primarily predispose to colorectal polyps, and each gene is associated with a specific type of polyp, whether conventional adenomas (APC, MUTYH, POLE, POLD1, NTHL1), juvenile polyps (SMAD4, BMPR1A), Peutz-Jeghers hamartomas (LKB1/STK11) and mixed polyps of serrated and juvenile types (GREM1).
|
26169059 |
2015 |
|
Colorectal Carcinoma
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
A new GWAS and meta-analysis with 1000Genomes imputation identifies novel risk variants for colorectal cancer.
|
25990418 |
2015 |
|
Colorectal Carcinoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
We then sought to investigate whether GREM1 is contextually and mechanistically associated with EMT in CRC.
|
25153376 |
2015 |