|
Neoplasms
|
0.200 |
Biomarker
|
group |
BEFREE |
In light of the active presence of GDNF in tumor microenvironment and necessity to overcome drug resistance, our findings can help in designing combined therapeutic strategies with implications for challenging TZMB resistance in BC.
|
29297700 |
2019 |
|
Neoplasms
|
0.200 |
AlteredExpression
|
group |
BEFREE |
GDNF neutralized TZMB activity and induced growth in all tumors.
|
28116540 |
2017 |
|
Neoplasms
|
0.200 |
Biomarker
|
group |
BEFREE |
However in vitro, NVP-AST487 was superior to letrozole in inhibiting the GDNF-induced motility and tumor spheroid growth of MCF7-AROM1 cells and required in combination with letrozole to inhibit GDNF-induced motility in BT474-AROM3 aromatase expressing cells.
|
27602955 |
2016 |
|
Neoplasms
|
0.200 |
Biomarker
|
group |
BEFREE |
Exposure to GDNF also induced tumor cell resistance to mitoxantrone and docetaxel chemotherapy.
|
25575823 |
2015 |
|
Neoplasms
|
0.200 |
AlteredExpression
|
group |
BEFREE |
GDNF expression in the tumors was positively correlated with RET and negatively correlated with p53.
|
25137025 |
2014 |
|
Neoplasms
|
0.200 |
Biomarker
|
group |
BEFREE |
Activating transcription factor 3 (ATF3) is a member of the ATF/CREB subfamily of the basic region-leucine zipper family and has been known as a tumor suppressor in human colorectal cancer cells.
|
20581861 |
2010 |
|
Neoplasms
|
0.200 |
Biomarker
|
group |
BEFREE |
Moreover nuclear factor (NF)-κB and other transcription factors like CREB, ATF-2 involved in tumour development and angiogenesis were also inhibited by harmine.
|
20858484 |
2010 |
|
Neoplasms
|
0.200 |
AlteredExpression
|
group |
BEFREE |
In this study, we showed that expression levels of intrinsic c-Ret, glial cell line-derived neurotrophic factor (Gdnf) and Gdnf receptor alpha 1 (Gfra1) transcripts in malignant melanomas from RET-transgenic mice were significantly upregulated compared with those in benign melanocytic tumors.
|
20422010 |
2010 |
|
Neoplasms
|
0.200 |
Biomarker
|
group |
BEFREE |
These studies suggest the functional link between the ATF-2 and the two tumor suppressors BRCA1 and p53.
|
17700520 |
2008 |
|
Neoplasms
|
0.200 |
Biomarker
|
group |
BEFREE |
Thus, ATF-2 acts as a tumor susceptibility gene of mammary tumors, at least partly, by activating a group of target genes, including Maspin and Gadd45alpha.
|
17189429 |
2007 |
|
Neoplasms
|
0.200 |
Biomarker
|
group |
BEFREE |
Germ line-activating oncogenic mutations in RET allow this receptor to signal independently of GFR alpha 1 and its ligand glial cell-derived neurotrophic factor (GDNF) to promote a spectrum of endocrine neoplasias.
|
18089803 |
2007 |
|
Neoplasms
|
0.200 |
PosttranslationalModification
|
group |
BEFREE |
However, little is known about the regulation of CREB and ATF-1 activities and their phosphorylation within the tumor microenvironment.
|
16306050 |
2006 |
|
Neoplasms
|
0.200 |
Biomarker
|
group |
BEFREE |
These cells could also survive and release GDNF 3 months following transplantation into the aged monkey brain.No tumors were found in any animal. hNPC can be genetically modified, and thereby represent a safe and powerful option for delivering growth factors to specific targets within the central nervous system for diseases such as Parkinson's.
|
16355116 |
2006 |
|
Neoplasms
|
0.200 |
Biomarker
|
group |
BEFREE |
A high-concentration of ATF-PAI2CD caused a significant reduction in tumor volume and weight in BALB/c (nu/nu) mice female inoculated with human 95D cells (5 x 10(6)); the antitumor effects were significant, which demonstrated a 67.9+/-4.2% reduction in tumor growth compared with control mice.
|
15490235 |
2005 |
|
Neoplasms
|
0.200 |
AlteredExpression
|
group |
BEFREE |
We investigated the NGF, BDNF, GDNF and NGF receptors (TrkA and p75) expression in the tumour tissues, cerebrospinal fluid (CSF) and plasma of ten children affected by low-grade astrocytomas and ependymomas.
|
15138791 |
2004 |
|
Neoplasms
|
0.200 |
Biomarker
|
group |
BEFREE |
The results presented support the notion of the possible involvment of glial cell line-derived neurotrophic factor (GDNF) with multiple endocrine neoplasia type 2A (MEN2A) tumours, and describe a useful tool for generating molecular mimetics directed towards specific mutations of the ret oncogene.
|
12630912 |
2003 |
|
Neoplasms
|
0.200 |
Biomarker
|
group |
BEFREE |
These regions house known tumor suppressor genes as well as genes encoding subunits of the multicomponent complex of glycosylphosphatidylinositol-linked proteins (glial cell line-derived neurotrophic factor family receptors alpha-2-4) and their ligands glial cell line-derived neurotrophic factor, neurturin, persephin, and artemin that facilitate RET dimerization and downstream signaling.
|
12679485 |
2003 |
|
Neoplasms
|
0.200 |
AlteredExpression
|
group |
BEFREE |
Whereas the GFRalpha-1 transcripts were detected at similar levels in normal tissues and in tumors, GDNF was frequently found expressed in sporadic tumors at levels several times higher than in controls.
|
10728700 |
2000 |
|
Neoplasms
|
0.200 |
GeneticVariation
|
group |
BEFREE |
Based on these, it is concluded that somatic mutations of the RET proto-oncogene or the GDNF gene do not appear to play a major role in the pituitary tumorigenesis in examined tumors.
|
10426588 |
1999 |
|
Neoplasms
|
0.200 |
GeneticVariation
|
group |
BEFREE |
This candidate mutation was identified in the germline and tumour tissue but was not present in 104 control GDNF alleles.
|
9215674 |
1997 |
|
Neoplasms
|
0.200 |
AlteredExpression
|
group |
BEFREE |
No disease-associated somatic GDNF mutations or gross gene amplification were detected in these tumors, suggesting only a minor role for GDNF in the genesis of phaeochromocytomas.
|
9000574 |
1997 |
|
Neoplasms
|
0.200 |
Biomarker
|
group |
HPO |
|
|
|