GDNF, glial cell derived neurotrophic factor, 2668

N. diseases: 409; N. variants: 13
Disease: Neuralgia ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0027796
Disease: Neuralgia
Neuralgia 		0.080 Biomarker phenotype BEFREE Studies have shown that glial cell-derived neurotrophic factor (GDNF) can relieve neuropathic pain. 31780260 2020
CUI: C0027796
Disease: Neuralgia
Neuralgia 		0.080 Biomarker phenotype BEFREE In order to elucidate the roles of miR-204 and GDNF in SCC-induced neuropathic pain, miR-204 sponge, GDNF, or shRNA against GDNF was introduced to the rats, followed by measurements for SCC-induced neuroinflammation and neuropathic pain. 31819204 2019
CUI: C0027796
Disease: Neuralgia
Neuralgia 		0.080 Biomarker phenotype BEFREE Spinal glial cell line-derived neurotrophic factor infusion reverses reduction of Kv4.1-mediated A-type potassium currents of injured myelinated primary afferent neurons in a neuropathic pain model. 30868936 2019
CUI: C0027796
Disease: Neuralgia
Neuralgia 		0.080 AlteredExpression phenotype BEFREE Pulsed Radiofrequency Improves Neuropathic Pain in Chronic Constriction Injury Rats through the Upregulation of the Transcription and Translation Levels of Glial Cell Line-Derived Neurotrophic Factor. 29357329 2018
CUI: C0027796
Disease: Neuralgia
Neuralgia 		0.080 Biomarker phenotype BEFREE Neublastin (BG00010) is a first-in-class, glial cell-derived neurotrophic factor shown in preclinical studies and an early clinical trial to have potential for the treatment of neuropathic pain. 28746076 2017
CUI: C0027796
Disease: Neuralgia
Neuralgia 		0.080 Biomarker phenotype BEFREE Moreover, pre-treatment with RET Ab could antagonize the effect of GDNF on inhibiting the NP induced by CCI. 29031858 2017
CUI: C0027796
Disease: Neuralgia
Neuralgia 		0.080 Biomarker phenotype BEFREE Two candidate targets are glial cell line-derived neurotrophic factor (GDNF) and artemin (ARTN), as these GDNF family ligands (GFLs) show efficacy in animal models of neuropathic pain (Boucher et al., 2000; Gardell et al., 2003; Wang et al., 2008, 2014). 28680400 2017
CUI: C0027796
Disease: Neuralgia
Neuralgia 		0.080 Biomarker phenotype BEFREE We investigated the therapeutic effects of adenoviral-mediated GDNF on neuropathic pain behaviors, microglial activation, pro-inflammatory cytokine expression and programmed cell death in a chronic constriction injury (CCI) nerve injury animal model. 24642655 2014