|
Depressed mood
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Glial cell line-derived neurotrophic factor (GDNF) as a neurotrophic factor closely related to depression is able to promote the growth, proliferation, differentiation, and survival of multiple neurons.
|
30445385 |
2019 |
|
Depressed mood
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Since changes in the dopamine system are implicated in several neuropsychiatric diseases, including schizophrenia, attention deficit hyperactivity disorder (ADHD) and depression, and ectopic GDNF delivery associates with side-effects in PD models and clinical trials, we further investigated Gdnf <sup>wt/hyper</sup> mice using 20 behavioral tests.
|
30089897 |
2018 |
|
Depressed mood
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Inflammation and trophic factors (brain-derived neurotrophic factor [BDNF], vascular endothelial growth factor, glial cell line-derived neurotrophic factor, and insulin-like growth factor-1) are associated with depression in the general population.
|
29787856 |
2018 |
|
Depressed mood
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Specifically, it describes (1) the implication of GDNF in the mechanism of depression and in the effect of antidepressant drugs and mood stabilizers and (2) the interrelation between GDNF and brain neurotransmitters, playing a key role in the pathogenesis of depression.
|
28099138 |
2017 |
|
Depressed mood
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Additionally, the presence or absence of GDNF has been correlated with conditions such as depression, pain, muscular soreness, etc.
|
28878618 |
2017 |
|
Depressed mood
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Together, these findings suggest the protein and mRNA expression levels of GDNF decreased in patients with depression.
|
28819313 |
2017 |
|
Depressed mood
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Correlations of GDNF with PANSS in schizophrenia and cholesterol level in depression have also been detected.
|
28689143 |
2017 |
|
Depressed mood
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
MicroRNA regulation of central glial cell line-derived neurotrophic factor (GDNF) signalling in depression.
|
25689572 |
2015 |
|
Depressed mood
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
An increased risk of HD and depression was associated with rs2910709 T/T genotype and rs884344 C allele, respectively, suggesting GDNF is a novel susceptibility gene for depression and HD.
|
24022000 |
2013 |
|
Depressed mood
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
Here we present an association study between eight (rs1981844, rs3812047, rs3096140, rs2973041, rs2910702, rs1549250, rs2973050 and rs11111) GDNF single nucleotide polymorphisms (SNPs) and anxiety and depression scores measured by the Hospital Anxiety and Depression Scale (HADS) on 708 Caucasian young adults with no psychiatric history.
|
24324616 |
2013 |
|
Depressed mood
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Depression and fatigue during chronic IFN-α administration were associated with alterations in the expression (OAS2) and transcriptional control (CREB/ATF) of genes linked to behavioral disorders including CFS and major depression, further supporting an immune contribution to these diseases.
|
22152193 |
2012 |