|
Central neuroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In this study, neurotoxin-induced GDNF overexpression was detected for the first time in MES23.5 DA immortalized neuroblastoma (MES23.5 DA) cells soon after 6-hydroxydopamine (6-OHDA) treatment.
|
31720997 |
2020 |
|
Central neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Moreover, GDNF modulates the rate of neuroblastoma (NB) and glioblastoma cancer cell proliferation.
|
28878618 |
2017 |
|
Central neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Herein we report that RET is required for NB cell proliferation and that the small molecule inhibitor regorafenib (BAY 73-4506) blocks glial cell derived neurotrophic factor (GDNF)-induced RET signaling in NB cells and inhibits NB growth both <i>in vitro</i> and <i>in vivo</i>.
|
29262623 |
2017 |
|
Central neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Recombinant lentiviral vectors were used to overexpress GDNF gene in hippocampal astrocytes of 3xTg-AD mice in vivo, and also in the MC65 human neuroblastoma that conditionally overexpresses the 99-residue carboxyl-terminal (C99) fragment of the amyloid precursor protein.
|
25119316 |
2014 |
|
Central neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Serial dilutions of GDNF-enriched conditioned medium from infected astrocytes added to growing neuroblastoma cell line SK-N-MC resulted in commensurate resistance against 6-OHDA toxicity.
|
21969113 |
2012 |
|
Central neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
These results suggest that RET signaling plays an important role in GDNF-induced enhancement of non-adherent proliferation of NB-39-nu cells, which might contribute to the metastasis of neuroblastoma.
|
19320641 |
2009 |
|
Central neuroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The main target for induction of cyclin D1 transcription by oncogenic ras in neuroblastoma cells is a cyclic AMP response element (CRE) located in proximal promoter sequences, and T3 represses the transcriptional activity of b-Zip transcription factors such as CREB (CRE-binding protein) or ATF-2 (activation transcription factor 2) that are direct targets of Rsk2 and bind to this sequence.
|
15314161 |
2004 |
|
Central neuroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Here we show that glial cell line-derived neurotrophic factor (GDNF) enhances CRMP-2 expression in TGW human neuroblastoma cells via activation of RET receptor tyrosine kinase.
|
15207709 |
2004 |
|
Central neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
N-Propargyl-1 (R)-aminoindan, rasagiline, increases glial cell line-derived neurotrophic factor (GDNF) in neuroblastoma SH-SY5Y cells through activation of NF-kappaB transcription factor.
|
14687604 |
2004 |
|
Central neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Here we report the ability of GDNF to induce proliferation, rather than differentiation, of neuroblastoma cells (SH-SY5Y) by targeting the signaling pathway responsible for mediating this proliferative effect.
|
12914961 |
2003 |
|
Central neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Immunostaining revealed that the expression of the SEP1 protein was detected in cell body, elongated neurites and growth cone-like structure of neuroblastoma cells treated with GDNF.
|
14580940 |
2003 |
|
Central neuroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Taken together, these results indicate that GDNF up-regulates the expression of the TH gene by promoting the transcription of the TH gene and the stability of TH mRNA with the Ret receptor dependency in some neuroblastoma cell lines.
|
12358785 |
2002 |
|
Central neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We show that the glial cell line-derived neurotrophic factor (GDNF) activates the PI3K/Akt-signaling pathway in human neuroblastoma cells that express functional Ret-receptor complexes.
|
12485836 |
2002 |
|
Central neuroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Differential regulation of glial cell line-derived neurotrophic factor (GDNF) expression in human neuroblastoma and glioblastoma cell lines.
|
9972821 |
1999 |
|
Central neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Interestingly, the expression of presenilin-1 in human U87 MG astrocytoma and human SK-N-SH neuroblastoma cells is only increased when cells are treated with glial cell line-derived neurotrophic factor or transforming growth factor-beta3.
|
10473269 |
1999 |
|
Central neuroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In addition, GDNF clearly activated a Ras-MAPK pathway in human neuroblastoma cells.
|
9299438 |
1997 |