|
Ovarian Failure, Premature
|
0.100 |
Biomarker
|
disease |
BEFREE |
In this study, we show that BMSC and BMSC-derived exosome transplantation can significantly recover the estrus cycle, increase the number of basal and sinus follicles in POF rats, increase estradiol (E<sub>2</sub>) and anti-Mullerian hormone (AMH) levels, and reduce follicle stimulating hormone (FSH) and luteinizing hormone (LH) levels in the serum.
|
31537899 |
2020 |
|
Ovarian Failure, Premature
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
However, the AMH assay can become an indirect marker of the remaining female fertile years in some cases such as those women that are at risk for premature ovarian failure or in those suffering from polycystic ovary syndrome.
|
31398713 |
2019 |
|
Ovarian Failure, Premature
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In patients with POI, exposure to PCBs was correlated with higher levels of LH, whereas exposure to OCPs was associated with lower levels of AMH.
|
31108393 |
2019 |
|
Ovarian Failure, Premature
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Expression of the male-specific Sry gene in the ovarian tissues of POI + PBMCs + PRP female recipient rats was evident at 5, 10, and 20 days posttransplantation along with significant increases in the expression of angiogenesis markers CD34+ and VEGF and folliculogenesis markers AMH and FSHR.
|
31034039 |
2019 |
|
Ovarian Failure, Premature
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
ROC curve AUC for primary POI showed the highest values for AMH (0.930) and AFC (0.944).
|
30558460 |
2019 |
|
Ovarian Failure, Premature
|
0.100 |
Biomarker
|
disease |
BEFREE |
Previous studies have suggested that deletion of Foxo3a, FoxL2, PTEN, p27, and AMH leads to early exhaustion of the primordial follicle pool and premature ovarian insufficiency (POI) in transgenic mice.
|
31637660 |
2019 |
|
Ovarian Failure, Premature
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
This research provides some insight into young women's current thoughts about the possibility of predicting POF with an AMH test.
|
31530237 |
2019 |
|
Ovarian Failure, Premature
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The ovaries of POI rats contained fewer antral and maturing follicles (p < 0.05) than those of control rats, whereas atretic follicles were increased significantly (p < 0.05), and AMH levels were significantly lower in the VCD group than in the control group (p < 0.05).
|
31152926 |
2019 |
|
Ovarian Failure, Premature
|
0.100 |
Biomarker
|
disease |
BEFREE |
At the last follow up, 35 patients had AMH below the expected values for age; eight presented postmenopausal FSH; ten had not recovered their ovarian function and five met the defined criteria for POI.
|
31672154 |
2019 |
|
Ovarian Failure, Premature
|
0.100 |
Biomarker
|
disease |
BEFREE |
AMH is regarded as a promising predictor for ovarian reserve in humans and non-human primate, and widely used in human medicine to predict ovarian response to gonadotropin, menopause and premature ovarian failure.
|
30243886 |
2018 |
|
Ovarian Failure, Premature
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Our results showed that the expression of IL-6, IL-21 and AMH were related to the occurrence and development of POF, IL-6, IL-21 and AMH can be used as the primary screening indexes for POF patients.
|
30233686 |
2018 |
|
Ovarian Failure, Premature
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
After hPMSC transplantation, the AMH and FSHR expression in ovarian tissue was significantly higher than in the POF group as determined by immunochemistry and western blot analysis.
|
29386068 |
2018 |
|
Ovarian Failure, Premature
|
0.100 |
Biomarker
|
disease |
BEFREE |
Thus treatment with MIS may provide a method of contraception with the unique characteristic of blocking primordial follicle activation that could be exploited to prevent the primary ovarian insufficiency often associated with chemotherapy.
|
28137855 |
2017 |
|
Ovarian Failure, Premature
|
0.100 |
Biomarker
|
disease |
BEFREE |
AMH can be used as a marker of sertoli/granulosa cell tumors and primary ovarian insufficiency in girls with delayed puberty, Turner Syndrome and after treatment with gonadotoxic agents.
|
28613046 |
2017 |
|
Ovarian Failure, Premature
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Previous studies have demonstrated the associations of several sequence variants in AMH or AMHR2 with POI, but no functional assay has been performed to verify whether there was any defect on AMH signaling.
|
27430550 |
2016 |
|
Ovarian Failure, Premature
|
0.100 |
Biomarker
|
disease |
BEFREE |
The familial segregation further supports the implication of AMH in the development of POI.
|
25750103 |
2015 |
|
Ovarian Failure, Premature
|
0.100 |
Biomarker
|
disease |
BEFREE |
DNA sequencing was used to detect the genotype distribution and allele frequency of the genes AMH and AMH receptor II (AMHR2) in 120 cases of idiopathic POI and 120 normal-ANM women.
|
24912417 |
2014 |
|
Ovarian Failure, Premature
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The frequency of the AMH Ile(49)Ser and AMHR2 -482A>G polymorphisms was analyzed in 211 patients with idiopathic POI and in 233 post-menopausal controls, and we also analyzed clinical characteristics, such as age at the time of POI and LH, FSH as well as estradiol levels according to the specific genotype.
|
24146295 |
2013 |
|
Ovarian Failure, Premature
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The women with autoimmune-driven POF have significantly higher anti-Mullerian hormone levels in comparison to women with non-autoimmune-driven POF.
|
23504400 |
2013 |
|
Ovarian Failure, Premature
|
0.100 |
Biomarker
|
disease |
BEFREE |
We developed a unique standardized AMH value, taking FMR1 premutation status and the subject's age into account, which appears to be stable over time and may serve as a predictor for FXPOI after further longitudinal assessment.
|
21576079 |
2011 |
|
Ovarian Failure, Premature
|
0.100 |
AlteredExpression
|
disease |
LHGDN |
Evaluation of different markers of the ovarian reserve in patients presenting with premature ovarian failure.
|
18191888 |
2008 |