Hypothyroidism
|
0.100 |
Biomarker
|
disease |
BEFREE |
Endocrinological evaluation revealed growth hormone and thyroid-stimulating hormone deficiency.
|
26302767 |
2015 |
Hypothyroidism
|
0.100 |
Biomarker
|
disease |
BEFREE |
POU1F1 (Pit-1; Gene ID 5449) is an anterior pituitary transcriptional factor, and POU1F1 mutation is known to cause anterior pituitary hypoplasia, growth hormone and prolactin deficiency and various degree of hypothyroidism.
|
21316014 |
2011 |
Hypothyroidism
|
0.100 |
Biomarker
|
disease |
BEFREE |
Mutations within POU1F1 are associated with GH, TSH and PRL deficiencies, with the TSH deficiency being highly variable.
|
18174732 |
2007 |
Hypothyroidism
|
0.100 |
Biomarker
|
disease |
BEFREE |
TSH deficiency was manifested after the initiation of GH and was treated with thyroxine while puberty was initiated with conjugated estrogens.
|
17162714 |
2006 |
Hypothyroidism
|
0.100 |
Biomarker
|
disease |
BEFREE |
Endocrinopathies are a common feature of FA, primarily manifesting as glucose/insulin abnormalities, GH insufficiency, and hypothyroidism.
|
11335753 |
2001 |
Hypothyroidism
|
0.100 |
Biomarker
|
disease |
BEFREE |
Development of a site-directed polyclonal antibody against the pituitary growth hormone-releasing hormone receptor and its use to estimate GHRH receptor concentration in normal and hypothyroid rats.
|
10461026 |
1999 |
Hypothyroidism
|
0.100 |
Biomarker
|
disease |
BEFREE |
We report a child whose hypothyroidism was recognized clinically at age 6 weeks, and subsequently found to have GH and Prl as well as TSH deficiency.
|
9485179 |
1998 |
Hypothyroidism
|
0.100 |
Biomarker
|
disease |
BEFREE |
Pit-1 gene mutations result in complete growth hormone (GH) and PRL deficiencies and variable degrees of TSH deficiency, producing the clinical syndrome of combined pituitary hormone deficiency (CPHD).
|
9588494 |
1998 |
Hypothyroidism
|
0.100 |
Biomarker
|
disease |
BEFREE |
However, as the involvement of PIT1 mutation is rare in Russia, the other negative cases need to be analyzed for another candidate gene responsible for combined GH/Pr/TSH deficiency.
|
9632165 |
1998 |
Hypothyroidism
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Growth hormone normalizes low-density lipoprotein receptor gene expression in hypothyroid rats.
|
8637440 |
1996 |
Hypothyroidism
|
0.100 |
Biomarker
|
disease |
BEFREE |
Four out of 10 children in two unrelated families presented with a total pituitary growth hormone (GH) and prolactin deficiency and a partial thyrotropin (TSH) deficiency.The GH gene was intact in family I.
|
2634610 |
1989 |
Hypothyroidism
|
0.100 |
Biomarker
|
disease |
BEFREE |
The syndrome is characterized by: adipsia-hypodipsia (5/5 patients), recurrent hypernatremia (5/5), obesity (4/5), inability to excrete a water load (5/5), lack of growth hormone release in response to provocative stimuli (4/4), blunted thyrotropin releasing hormone responses (3/4), hypothyroidism (2/4), and hyperlipemia associated with hypernatremic crisis (1/1).
|
6808452 |
1982 |