Turner Syndrome
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Treatment with growth hormone (GH) during childhood has indisputable benefits when taking into account the low stature of TS women.
|
31685880 |
2019 |
Turner Syndrome
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The cohort consisted of 94 girls and young women with TS born between 1971 and 2001 (age range: 3.1-23.2 yrs.), who were treated with human growth hormone and regularly presented at our outpatient clinic every 4 to 6 months.The longitudinal data of all patients were ascertained retrospectively from patient charts.
|
30658614 |
2019 |
Turner Syndrome
|
0.400 |
Biomarker
|
disease |
BEFREE |
We aimed to clarify whether the loss of a specific X chromosome gene locus and the administration of GH and estradiol facilitate the development of AIDs in TS females.
|
31075085 |
2019 |
Turner Syndrome
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We included randomised controlled clinical trials (RCTs) that enrolled girls aged up to 18 years with TS who were treated with GH and oxandrolone compared with GH only treatment.
|
31684688 |
2019 |
Turner Syndrome
|
0.400 |
Biomarker
|
disease |
BEFREE |
These included recurrent parathyroid adenomas, growth along the 75<sup>th</sup>-90<sup>th</sup> centiles on the TS height curve despite minimal treatment with growth hormone, behavioral problems and evidence of gonadal dysgenesis with testicular-like structures, such as seminiferous tubules lined by Sertoli cells and a contiguous nodule of Leydig cells.
|
29739732 |
2019 |
Turner Syndrome
|
0.400 |
Biomarker
|
disease |
BEFREE |
Here, we will review the history of our understanding of growth in TS, reflect on the path of clinical trials ultimately leading to regulatory approval for clinical use of GH, discuss factors associated with growth outcomes and survey the current unanswered questions about growth and GH in TS.
|
30811776 |
2019 |
Turner Syndrome
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Health-Related Quality of Life in Turner Syndrome and the Influence of Growth Hormone Therapy: A 20-Year Follow-Up.
|
31009056 |
2019 |
Turner Syndrome
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Here, we present an updated Review of Turner syndrome, covering advances in genetic and genomic mechanisms of disease, associated disorders and multidisciplinary approaches to patient management, including growth hormone therapy and hormone replacement therapy.
|
31213699 |
2019 |
Turner Syndrome
|
0.400 |
Biomarker
|
disease |
BEFREE |
Treatment with GH was undertaken for 247/255 patients with GHD and 29/30 with TS.
|
31696446 |
2019 |
Turner Syndrome
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Search of an international database of children treated with GH revealed 772 girls with Turner syndrome followed from GH initiation to near adult height.
|
31227282 |
2019 |
Turner Syndrome
|
0.400 |
Biomarker
|
disease |
BEFREE |
Growth Hormone Supplementation and Psychosocial Functioning to Adult Height in Turner Syndrome: A Questionnaire Study of Participants in the Canadian Randomized Trial.
|
30930850 |
2019 |
Turner Syndrome
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Thus, we aimed to assess serum AMH levels in girls with TS and its relation to karyotype, spontaneous puberty, and growth hormone (GH) therapy.
|
30088853 |
2018 |
Turner Syndrome
|
0.400 |
Biomarker
|
disease |
BEFREE |
Growth Hormone Therapy for Turner Syndrome.
|
30378785 |
2018 |
Turner Syndrome
|
0.400 |
Biomarker
|
disease |
BEFREE |
In addition, greater awareness for TS may underlie trends to earlier start of GH therapy and induction of puberty at a more physiological age.
|
29541059 |
2018 |
Turner Syndrome
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
This study aimed to systematically review the available literature on "quality of life" (QoL) or "health-related quality of life" (HRQoL) in Turner syndrome (TS) patients and to analyze the relations among height, puberty, and the use of growth hormone (GH) and the QoL of TS patients.
|
29427215 |
2018 |
Turner Syndrome
|
0.400 |
Biomarker
|
disease |
BEFREE |
Treatment with growth hormone (GH) is standard clinical practice in children with GH deficiency (GHD) or Turner syndrome (TS).
|
30836359 |
2018 |
Turner Syndrome
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The mean baseline GH doses were largely within recommended ranges for GHD and SGA, but below the lowest recommended starting dose for TS in almost every year since 2011 except in France.
|
29652668 |
2018 |
Turner Syndrome
|
0.400 |
Biomarker
|
disease |
BEFREE |
In particular, almost half of girls with TS received GH doses below practice guidelines and label recommendations.
|
28522645 |
2017 |
Turner Syndrome
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
At the start of GH girls with TS showed insignificantly higher REE per FFM (REE/FFM) (mean±SD; 65±9 kcal/kg×day) than did the other female patients (62±9 kcal/kg×day) (p>0.23).
|
28236628 |
2017 |
Turner Syndrome
|
0.400 |
Biomarker
|
disease |
BEFREE |
Growth prediction models (GPMs) exist to support clinical management of children treated with growth hormone (GH) for growth hormone deficiency (GHD), Turner syndrome (TS) and for short children born small for gestational age (SGA).
|
28902629 |
2017 |
Turner Syndrome
|
0.400 |
Biomarker
|
disease |
BEFREE |
Validating genetic markers of response to recombinant human growth hormone in children with growth hormone deficiency and Turner syndrome: the PREDICT validation study.
|
27651465 |
2016 |
Turner Syndrome
|
0.400 |
Biomarker
|
disease |
BEFREE |
This family illustrates the complexity and difficulties in counseling, follow-up and treatment in Turner syndrome, namely referring to a tertiary center, fertility and treatment such as growth hormone and hormonal replacement, due to the heterogeneity of the clinical spectrum.
|
26824976 |
2016 |
Turner Syndrome
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Why Treat girls with Turner Syndrome with Growth Hormone? Growth and Beyond.
|
26182480 |
2015 |
Turner Syndrome
|
0.400 |
Biomarker
|
disease |
BEFREE |
This prospective, phase IV study used an integrated genomic analysis to identify markers associated with 1-month change in IGF-I (ΔIGF-I) following initiation of recombinant human (r-h)GH therapy in treatment-naïve children with GH deficiency (GHD) (n=166) or Turner syndrome (TS) (n=147).
|
23567489 |
2014 |
Turner Syndrome
|
0.400 |
Biomarker
|
disease |
BEFREE |
Genotypes were correlated with adult height data of 65 Turner syndrome (TS) and 47 GH deficiency (GHD) patients treated with rhGH, by multiple linear regressions.
|
24905066 |
2014 |