|
Isolated somatotropin deficiency
|
0.500 |
Biomarker
|
disease |
BEFREE |
Effects of growth hormone therapy in pediatric patients with growth hormone deficiency and Chiari I malformation: a retrospective study.
|
31502034 |
2020 |
|
Isolated somatotropin deficiency
|
0.500 |
Biomarker
|
disease |
BEFREE |
Efficacy and safety of a biosimilar recombinant human growth hormone (r-hGH Cristalia) compared with reference r-hGH in children with growth hormone deficiency (CERES study): A randomized, multicentric, investigator-blind, phase 3 trial.
|
31493626 |
2020 |
|
Isolated somatotropin deficiency
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
We describe a non-consanguineous pedigree composed by several individuals with short stature, including 2 pediatric patients with typical diagnosis of isolated growth hormone deficiency (IGHD) and 4 other siblings with severe short stature, low serum IGF-1 and IGFBP-3, but normal stimulated GH levels, suggesting growth hormone insensitivity (GHI) in the latter group.
|
31835104 |
2020 |
|
Isolated somatotropin deficiency
|
0.500 |
Biomarker
|
disease |
BEFREE |
Although not yet well-understood, today it is clear that Growth Hormone (GH) exerts a relevant role in the regulation of ovulation and fertility; in fact, fertility is lower in women with GH deficiency (GHD), and GH receptors (GHR) and GH mRNA have been found in the ovary since the onset of follicular development in humans.
|
31379735 |
2019 |
|
Isolated somatotropin deficiency
|
0.500 |
Biomarker
|
disease |
BEFREE |
As a consequence, hGH is prescribed under conditions of GH deficiency and, because of its lipolytic activity, stimulation of hGH release has also been used to treat obesity.
|
30227383 |
2019 |
|
Isolated somatotropin deficiency
|
0.500 |
Biomarker
|
disease |
BEFREE |
Because GH replacement therapy has been shown to improve mood and quality of life in patients with GH deficiency, this emerging area may hold promise for patients suffering from epilepsy-related depression.
|
30773449 |
2019 |
|
Isolated somatotropin deficiency
|
0.500 |
Biomarker
|
disease |
BEFREE |
Growth hormone (GH) stimulation tests were performed 3-4 years post TBI in children with GH deficiency (GHD) 1 year post TBI and in all children with low height velocity (<-1 DS) or low IGF-1 (<-2 DS).
|
30884465 |
2019 |
|
Isolated somatotropin deficiency
|
0.500 |
Biomarker
|
disease |
BEFREE |
Somapacitan, a long-acting growth hormone (GH) derivative, has been well-tolerated in children with GH deficiency (GHD) and adults (healthy and adult GHD), in phase I, single- and multiple-dose trials, respectively, and has pharmacokinetic and pharmacodynamic properties supporting a once-weekly dosing regimen.
|
29671202 |
2019 |
|
Isolated somatotropin deficiency
|
0.500 |
Biomarker
|
disease |
BEFREE |
The long-acting growth hormone (LAGH) is a promising alternative biopharmaceutical to treat growth hormone (GH) deficiency in children, and it was developed using a variety of technologies by several pharmaceutical companies.
|
30970583 |
2019 |
|
Isolated somatotropin deficiency
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Use of PEGylated Recombinant Human Growth Hormone in Chinese Children with Growth Hormone Deficiency: A 24-Month Follow-Up Study.
|
31641350 |
2019 |
|
Isolated somatotropin deficiency
|
0.500 |
Biomarker
|
disease |
BEFREE |
While growth hormone (GH) and the insulin-like growth factor type I (IGF-I) are known to exert synergistic actions on muscle anabolism, the consequences of prolonged GH deficiency (GHD) on muscle function have not been well defined.
|
30251164 |
2019 |
|
Isolated somatotropin deficiency
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The in vitro functional analysis of single-nucleotide polymorphisms associated with growth hormone (GH) response in children with GH deficiency.
|
29855605 |
2019 |
|
Isolated somatotropin deficiency
|
0.500 |
Biomarker
|
disease |
BEFREE |
Impact of BMI on peak growth hormone responses to provocative tests and therapeutic outcome in children with growth hormone deficiency.
|
31700044 |
2019 |
|
Isolated somatotropin deficiency
|
0.500 |
Biomarker
|
disease |
BEFREE |
Conclusion To the best of our knowledge, this is the first patient with APS showing partial empty sella and GH deficiency that might have contributed to his poor growth.GH failed to improve long-term outcome.
|
31199775 |
2019 |
|
Isolated somatotropin deficiency
|
0.500 |
Biomarker
|
disease |
BEFREE |
Long-term growth hormone (GH) replacement of adult GH deficiency (GHD) benefits the heart.
|
31100717 |
2019 |
|
Isolated somatotropin deficiency
|
0.500 |
Biomarker
|
disease |
BEFREE |
As indicated by the growth hormone provocation test, the boy had growth hormone deficiency.
|
31576764 |
2019 |
|
Isolated somatotropin deficiency
|
0.500 |
Biomarker
|
disease |
BEFREE |
Evidence of efficacy of GH in GH deficiency, Turner syndrome and short children born small for gestational age is reviewed.
|
31284701 |
2019 |
|
Isolated somatotropin deficiency
|
0.500 |
Biomarker
|
disease |
BEFREE |
Two different GH stimulation tests revealed GH deficiency in the younger sister with short stature.
|
30625464 |
2019 |
|
Isolated somatotropin deficiency
|
0.500 |
Biomarker
|
disease |
BEFREE |
However, the necessity of growth hormone administration and the profile of the infertile patients with growth hormone deficiency who would benefit from treatment are largely unknown.
|
29975109 |
2019 |
|
Isolated somatotropin deficiency
|
0.500 |
Biomarker
|
disease |
BEFREE |
Short- and long-term responsiveness to low dose growth hormone (GH) in adult GH deficiency: Role of GH receptor polymorphism.
|
30712287 |
2019 |
|
Isolated somatotropin deficiency
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Accuracy and Limitations of the Growth Hormone (GH) Releasing Hormone-Arginine Retesting in Young Adults With Childhood-Onset GH Deficiency.
|
31417499 |
2019 |
|
Isolated somatotropin deficiency
|
0.500 |
Biomarker
|
disease |
BEFREE |
Growth hormone and hematopoiesis: A retrospective analysis on a large cohort of children with growth hormone deficiency.
|
30053742 |
2019 |
|
Isolated somatotropin deficiency
|
0.500 |
Biomarker
|
disease |
BEFREE |
Therefore, the early establishment of GH replacement therapy can correct craniofacial morphological changes induced by GH deficiency.
|
31658340 |
2019 |
|
Isolated somatotropin deficiency
|
0.500 |
Biomarker
|
disease |
BEFREE |
Additional areas that are expected to transform the growth field include the development of long-acting growth hormone preparations and other new therapeutics and diagnostics that may increase adult height or aid in the diagnosis of growth hormone deficiency.
|
31514194 |
2019 |
|
Isolated somatotropin deficiency
|
0.500 |
Biomarker
|
disease |
BEFREE |
Complete or partial hypopituitarism (isolated growth hormone (GH) deficiency as most frequent) may occur after mild TBI equally as after moderate-to-severe TBI.
|
30929221 |
2019 |