Cushing Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
<b>Conclusion:</b> This is the first report of interspersed myelolipoma and BMAH with GIP-dependent Cushing's syndrome.
|
31572300 |
2019 |
Cushing Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
Altogether, our results provide insight into the molecular pathogenesis of GIP-dependent Cushing's syndrome, occurring through monoallelic transcriptional activation of GIPR driven in some adrenal lesions by structural variations.
|
28931750 |
2017 |
Cushing Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
This case report illustrates the lack of sustained efficacy of somatostatin analogues on GIP-dependent Cushing's syndrome, independent of their affinity for the different somatostatin receptor subtypes.
|
21264796 |
2011 |
Cushing Syndrome
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We observed that enforcing expression of the gastric inhibitory polypeptide (GIP) receptor or the luteinizing hormone (LH) receptor genes (taken as canonical examples of aberrantly expressed GPCRs) in adrenocortical cells resulted in the formation of hyperplastic tissues and the development of Cushing syndrome features in transplanted mice.
|
17250952 |
2007 |
Cushing Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
The mechanisms responsible for the ectopic adrenal expression of glucose-dependent insulinotropic peptide (GIP) receptor (GIPR) in GIP-dependent Cushing's syndrome (CS) are unknown.
|
16772347 |
2006 |
Cushing Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
However, cortisol secretion occurs in response to gastric inhibitory polypeptide (GIP) in rare cases of food-dependent Cushing's syndrome (CS).
|
15705925 |
2005 |
Cushing Syndrome
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Abnormal responses were observed in three patients with Cushing's syndrome; one patient showed a gastric inhibitory polypeptide (GIP)-dependent cortisol rise after meal, together with responses after GnRH and cisapride; the second patient showed an LH-dependent cortisol response to GnRH, and in the third cortisol rose after cisapride.
|
15326569 |
2004 |
Cushing Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
In conclusion, mutations or SNPs in the regulatory region of the GIPR gene are unlikely to underlie GIP-dependent CS.
|
15276624 |
2004 |
Cushing Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
In food-dependent Cushing's syndrome the adrenals aberrantly express receptors for gastric inhibitory polypeptide (GIP).
|
12099397 |
2002 |
Cushing Syndrome
|
0.100 |
GeneticVariation
|
disease |
LHGDN |
Analysis of the putative promoter region of the GIP receptor gene (GIPR) in GIP-dependent Cushing's syndrome (CS).
|
12530694 |
2002 |
Cushing Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
Gastric inhibitory polypeptide (GIP) stimulates cortisol secretion, cAMP production and DNA synthesis in an adrenal adenoma responsible for food-dependent Cushing's syndrome.
|
9888586 |
1999 |
Cushing Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
Asynchronous development of bilateral nodular adrenal hyperplasia in gastric inhibitory polypeptide-dependent cushing's syndrome.
|
10443649 |
1999 |
Cushing Syndrome
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In conclusion, the present data demonstrate that ectopic expression of functional GIP receptors is the main cause of food-dependent Cushing's syndrome.
|
9851802 |
1998 |
Cushing Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
Cushing's syndrome due to a gastric inhibitory polypeptide-dependent adrenal adenoma: insights into hormonal control of adrenocortical tumorigenesis.
|
9745416 |
1998 |
Cushing Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
We conclude that the GIPR overexpression and its coupling to steroidogenesis underlie GIP-dependent Cushing's syndrome.
|
9709947 |
1998 |
Cushing Syndrome
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We conclude that food-dependent Cushing's syndrome results from the expression of GIP receptors on adrenocortical adenoma cells.
|
8784063 |
1996 |
Cushing Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
The pathogenesis of AIMBAD appears to be heterogeneous, as recent reports have demonstrated GIP-mediated hypercortisolism and familial AIMBAD.
|
8038906 |
1994 |