|
Colitis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
It was found that the supplementation of KDCE could alleviate typical symptoms of IBD including weight loss, colon shortening, intestinal barrier damage, and decreases in the colitis disease activity index and pro-inflammatory cytokines.
|
31732076 |
2019 |
|
Colitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Of 775 patients with long-standing IBD colitis, 44% (n=340) had <u>></u>1 negative colonoscopy.
|
29720408 |
2019 |
|
Colitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Low-dose As<sub>2</sub>O<sub>3</sub> use as a mean of preventing the acute phase of colitis can be seen as an interesting approach which counts as a great addition to IBD available treatments.
|
30415273 |
2019 |
|
Colitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
We demonstrated serum (1→3)-β-D-glucan (BG) elevation in patients with IBD and endoscopic moderate colitis in clinical remission, supporting the possible influence of gut fungi toward IBD in human.
|
31530137 |
2019 |
|
Colitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Colitis was established in CD177<sup>-/-</sup> and wild-type mice in response to dextran sulfate sodium (DSS) insults to determine the role of CD177<sup>+</sup> neutrophils in IBD.
|
28468761 |
2018 |
|
Colitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Patients with inflammatory bowel disease [IBD] colitis are at increased risk for colorectal cancer [CRC].
|
29648663 |
2018 |
|
Colitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Disturbance of intestinal homeostasis is associated with the development of inflammatory bowel disease [IBD], and TGF-β signalling impairment in mononuclear phagocytes [MPs] causes murine colitis with goblet cell depletion.
|
29917067 |
2018 |
|
Colitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Absence of GPR4 ameliorates colitis in IBD animal models, indicating an important regulatory role in mucosal inflammation, thus providing a new link between tissue pH and the immune system.
|
29136128 |
2018 |
|
Colitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Oxazolone-induced colitis has been frequently used in literature as a model of IBD, but insights into the underlying immune response and pathological features are surprisingly still very limited.
|
29791477 |
2018 |
|
Colitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Convergent functions of epithelial and myeloid HuR included their requirement for suppressing inflammation in chemically induced colitis and their redundancies in chronic TNF-driven IBD and microbiota control.
|
30532756 |
2018 |
|
Colitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The purpose of this Review is to summarize current associations between IBD and dysbiosis, describe the role of the gut microbiota in the context of specific animal models of colitis, and discuss the potential role of microbiota-focused interventions in the treatment of human IBD.
|
28743984 |
2017 |
|
Colitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
RKIP contributes to colitis development by promoting inflammation and mediating IEC apoptosis and might represent a therapeutic target of IBD.
|
26801887 |
2017 |
|
Colitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Epidemiological and clinical data indicate that patients suffering from IBD with long-standing colitis display a higher risk to develop colorectal high-grade dysplasia.
|
27371534 |
2017 |
|
Colitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Among ICOS+CD4+ T cells, conventional CD4+ T cells were the main T cell population in patents with αCTLA-4-induced colitis, whereas Treg cells were predominant in IBD or αPD-1-induced colitis.
|
28967957 |
2017 |
|
Colitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Here we define the in vivo role of BVES in colitis-associated cancer (CAC), its cellular function and its relevance to patients with IBD.
|
28389570 |
2017 |
|
Colitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Study population comprised 144 case patients who developed CRC from the diagnosis of IBD (65 and 79 cases diagnosed, respectively, before and from 2004, starting year of the prospective observational period of CESAME) and 286 controls matched for gender, age, IBD subtype and year of diagnosis, and cumulative extent of colitis.
|
27995656 |
2017 |
|
Colitis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Genes shown to be significantly dysregulated in human IBD were used to study gene expression in colons from a piroxicam-accelerated colitis interleukin-10 knockout [PAC IL-10 k.o.
|
25795566 |
2015 |
|
Colitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Furthermore, the level of IL-6, a pleiotropic cytokine which is implicated in the pathogenesis of IBD and colitis-associated cancer, was suppressed by DPhP in rat colon tissue and serum.
|
22410118 |
2012 |
|
Colitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In contrast to our original hypothesis, no defect of the anti-inflammatory potential of TGFβ and IL10 was observed in children with IBD or EO-IBD except two infants who presented with granuloma-positive colitis at 3 months of life: no response to IL10 was observed secondary to mutations in the α (p.R262C) or β (p.E141X) chain of IL10R, respectively, although a fully functional Jak-STAT3 pathway was present in both patients.
|
21519361 |
2011 |
|
Colitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
These findings suggest a disease-promoting role of complement, particular C5a, in the pathology of TNBS-induced colitis in mice, indicating possible therapeutic potentials for C5a-specific antibody in IBD.
|
21102504 |
2011 |
|
Colitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
a recent study in a mouse model of colitis has demonstrated that interleukin (Il)‑13, through inhibition of the mixed type 1 and type 17 T‑helper cell inflammatory response, has a protective effect. the decoyreceptor Il‑13rα2 inhibits this protective effect, suggesting blockade of Il‑13rα2 as a potential therapy for patients with IBD.
|
21304479 |
2011 |
|
Colitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Proinflammatory role of vasopressin through V1b receptors in hapten-induced experimental colitis in rodents: implication in IBD.
|
20864658 |
2010 |