Keratoderma, Palmoplantar
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
Neoplasms
|
0.060 |
AlteredExpression
|
group |
BEFREE |
In EGFR-mutant NSCLC patients, ANKRD1 was overexpressed in the tumor after the failure of EGFR-TKI therapy, especially after long-duration EGFR-TKI treatments.
|
30291293 |
2018 |
Neoplasms
|
0.060 |
AlteredExpression
|
group |
BEFREE |
We wanted to assess the expression of CARPs VIII and XI in these tumors and study their association to different clinicopathological features and tumor-associated CAs II, IX and XII.
|
29792187 |
2018 |
Neoplasms
|
0.060 |
AlteredExpression
|
group |
BEFREE |
Both epinephrine (EPI) and norepinephrine (NE) could directly inhibit breast cancer cell viability, as well as tumor growth <i>in vivo</i> EPI and NE activate the tumor suppressor Hippo signaling pathway, and the suppressive effect of exercise-conditioned serum was found to be mediated through phosphorylation and cytoplasmic retention of YAP and reduced expression of downstream target genes, for example, ANKRD1 and CTGF.
|
28887324 |
2017 |
Neoplasms
|
0.060 |
Biomarker
|
group |
BEFREE |
Additionally, our data indicate that the tumor-suppressive effect of ANKRD1 depends on the presence of p53.
|
29179447 |
2017 |
Neoplasms
|
0.060 |
GeneticVariation
|
group |
BEFREE |
CARP is a potential tumor suppressor in gastric carcinoma and a single-nucleotide polymorphism in CARP gene might increase the risk of gastric carcinoma.
|
24870804 |
2014 |
Neoplasms
|
0.060 |
AlteredExpression
|
group |
BEFREE |
These findings suggest that ANKRD1, a gene not previously associated with ovarian cancer or with response to chemotherapy, is associated with treatment outcome, and decreasing ANKRD1 expression, or function, is a potential strategy to sensitize tumors to platinum-based drugs.
|
18980987 |
2008 |
Heart failure
|
0.040 |
Biomarker
|
disease |
BEFREE |
Importantly, cardiac ANKRD1 has been shown to be highly induced in various cardiomyopathies and in heart failure, although it is still unclear what impact this may have on the pathophysiology of heart failure.
|
28672880 |
2017 |
Congestive heart failure
|
0.040 |
Biomarker
|
disease |
BEFREE |
Importantly, cardiac ANKRD1 has been shown to be highly induced in various cardiomyopathies and in heart failure, although it is still unclear what impact this may have on the pathophysiology of heart failure.
|
28672880 |
2017 |
Heart failure
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
ANKRD1 and RHOU mRNA levels were related with LV function which emphasizes their relevance in HF.
|
24709777 |
2014 |
Congestive heart failure
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
ANKRD1 and RHOU mRNA levels were related with LV function which emphasizes their relevance in HF.
|
24709777 |
2014 |
Heart failure
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
The ANKRD1 gene is over-expressed in heart failure in human and animal models.
|
19525294 |
2009 |
Heart failure
|
0.040 |
Biomarker
|
disease |
BEFREE |
The upregulation of nuclear CARP expression and positive correlation between cardiac CARP and proANP suggests that CARP may be used as a genetic marker existing in the nuclei in contrast to proANP existing in the cytosol of cardiac cells in heart failure patients.
|
19359327 |
2009 |
Congestive heart failure
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
The ANKRD1 gene is over-expressed in heart failure in human and animal models.
|
19525294 |
2009 |
Congestive heart failure
|
0.040 |
Biomarker
|
disease |
BEFREE |
The upregulation of nuclear CARP expression and positive correlation between cardiac CARP and proANP suggests that CARP may be used as a genetic marker existing in the nuclei in contrast to proANP existing in the cytosol of cardiac cells in heart failure patients.
|
19359327 |
2009 |
Total anomalous pulmonary venous return
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
Increased ANKRD1 levels linked to gain of function mutations have been associated to total anomalous pulmonary venous return and adult cardiomyopathy occurrence in humans.
|
31688894 |
2019 |
Total anomalous pulmonary venous return
|
0.030 |
Biomarker
|
disease |
BEFREE |
TAPVR has also been linked to the ANKRD1/CARP genes.
|
26121141 |
2015 |
Cardiomyopathy, Familial Idiopathic
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
According to our epidemiological data, the prevalence of ANKRD1 mutations seems to be lower than that of its binding partner myopalladin, indicating the clinical significance of myopalladin for the functional integrity of the sarcomeric apparatus and the protection against DCM.
|
22892539 |
2013 |
Cardiomyopathy, Familial Idiopathic
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
On the basis of genetic and functional analysis of CARP mutations, we have identified ANKRD1 as a new gene associated with DCM, accounting for approximately 2% of cases.
|
19525294 |
2009 |
Cardiomyopathy, Familial Idiopathic
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
The ANKRD1 mutations may cause DCM as a result of disruption of the normal cardiac stretch-based signaling.
|
19608030 |
2009 |
Total anomalous pulmonary venous return
|
0.030 |
Biomarker
|
disease |
BEFREE |
Taken together, these results define ANKRD1 as a possible candidate gene for TAPVR pathogenesis.
|
18273862 |
2008 |
Cardiovascular Diseases
|
0.020 |
Biomarker
|
group |
BEFREE |
The current views on the actions of ANKRD1 in cardiovascular disease and its utility as a candidate cardiac biomarker with diagnostic and/or prognostic potential are also discussed.
|
28672880 |
2017 |
Cardiovascular Diseases
|
0.020 |
AlteredExpression
|
group |
BEFREE |
Previous studies have demonstrated that CARP is up-regulated in some cardiovascular disorders and muscle diseases; however, its role in these diseases remains controversial now.
|
27143260 |
2016 |
Hypertrophic obstructive cardiomyopathy
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Impact of ANKRD1 mutations associated with hypertrophic cardiomyopathy on contraction parameters of engineered heart tissue.
|
23572067 |
2013 |
Hypertrophic obstructive cardiomyopathy
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Cardiac ankyrin repeat protein gene (ANKRD1) mutations in hypertrophic cardiomyopathy.
|
19608031 |
2009 |