AFF4, AF4/FMR2 family member 4, 27125

N. diseases: 62; N. variants: 12
Disease: Childhood Leukemia ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1332977
Disease: Childhood Leukemia
Childhood Leukemia 		0.030 Biomarker disease BEFREE These findings suggest that AFF4/SEC could be a potential therapeutic target for the treatment of leukemia or other cancers associated with MYC overexpression. 22547686 2012
CUI: C1332977
Disease: Childhood Leukemia
Childhood Leukemia 		0.030 AlteredExpression disease BEFREE Knockdown of AFF4 in leukemic cells shows reduction in MLL chimera target gene expression, suggesting that AFF4/SEC could be a key regulator in the pathogenesis of leukemia through many of the MLL partners. 20159561 2010
CUI: C1332977
Disease: Childhood Leukemia
Childhood Leukemia 		0.030 AlteredExpression disease BEFREE MCEF, the newest member of the AF4 family of transcription factors involved in leukemia, is a positive transcription elongation factor-b-associated protein. 12065898 2003