AGO2, argonaute RISC catalytic component 2, 27161

N. diseases: 186; N. variants: 11
Disease: Hepatitis B ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0019163
Disease: Hepatitis B
Hepatitis B 		0.030 PosttranslationalModification disease BEFREE In conclusion, miR‑20a may be loaded onto AGO2, prior to its translocation into the nucleus, inducing the methylation of HBV DNA in human hepatoma cells, leading to the suppression of HBV replication. 31257511 2019
CUI: C0019163
Disease: Hepatitis B
Hepatitis B 		0.030 AlteredExpression disease BEFREE We show in the present study that the siRNA-mediated silencing of Drosha, Dicer and Ago2 [argonaute RISC (RNA-induced silencing complex) catalytic component 2] transcripts in Huh7 cells resulted in elevated levels of HBV (hepatitis B virus)-specific RNAs and, conversely, we observed a decrease in mRNA and protein levels of same RNAi components in HepG2 cells infected with HBV. 24902849 2014
CUI: C0019163
Disease: Hepatitis B
Hepatitis B 		0.030 Biomarker disease BEFREE Hepatitis B virus-specific miRNAs and Argonaute2 play a role in the viral life cycle. 23091627 2012