AGO2, argonaute RISC catalytic component 2, 27161

N. diseases: 186; N. variants: 11
Disease: Penis carcinoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0853105
Disease: Penis carcinoma
Penis carcinoma 		0.010 GeneticVariation disease BEFREE We also identified recurrent mutations in the novel penile cancer tumor suppressor genes CSN1(GPS1) and FAT1 Expression of CSN1 mutants in cells resulted in colocalization with AGO2 in cytoplasmic P-bodies, ultimately leading to the loss of miRNA-mediated gene silencing, which may contribute to disease etiology. 27325650 2016