|
Gastrointestinal Stromal Tumors
|
0.300 |
Biomarker
|
group |
CTD_human |
Hedgehog pathway dysregulation contributes to the pathogenesis of human gastrointestinal stromal tumors via GLI-mediated activation of KIT expression.
|
27793025 |
2016 |
|
Gastrointestinal Stromal Sarcoma
|
0.300 |
Biomarker
|
disease |
CTD_human |
Hedgehog pathway dysregulation contributes to the pathogenesis of human gastrointestinal stromal tumors via GLI-mediated activation of KIT expression.
|
27793025 |
2016 |
|
Burkitt Lymphoma
|
0.300 |
Biomarker
|
disease |
CTD_human |
The genetic landscape of mutations in Burkitt lymphoma.
|
23143597 |
2012 |
|
African Burkitt's lymphoma
|
0.300 |
Biomarker
|
disease |
CTD_human |
The genetic landscape of mutations in Burkitt lymphoma.
|
23143597 |
2012 |
|
Burkitt Leukemia
|
0.300 |
Biomarker
|
disease |
CTD_human |
The genetic landscape of mutations in Burkitt lymphoma.
|
23143597 |
2012 |
|
Craniofacial Abnormalities
|
0.300 |
Biomarker
|
group |
CTD_human |
Loss of the Sall3 gene leads to palate deficiency, abnormalities in cranial nerves, and perinatal lethality.
|
15282310 |
2004 |
|
Colorectal Carcinoma
|
0.300 |
GeneticVariation
|
disease |
UNIPROT |
|
|
|
|
Body mass index
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
Body mass index
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Meta-analysis of genome-wide association studies for body fat distribution in 694 649 individuals of European ancestry.
|
30239722 |
2019 |
|
mathematical ability
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals.
|
30038396 |
2018 |
|
Malignant Neoplasms
|
0.020 |
GeneticVariation
|
group |
BEFREE |
We identified 92 CpG islands significantly hypermethylated in thymic carcinoma in relation to thymoma and selected G protein subunit gamma 4 (GNG4), growth hormone secretagogue receptor (GHSR), homeobox D9 (HOXD9) and spalt like transcription factor 3 (SALL3), which are related to cancer.
|
31746370 |
2020 |
|
Primary malignant neoplasm
|
0.020 |
GeneticVariation
|
group |
BEFREE |
We identified 92 CpG islands significantly hypermethylated in thymic carcinoma in relation to thymoma and selected G protein subunit gamma 4 (GNG4), growth hormone secretagogue receptor (GHSR), homeobox D9 (HOXD9) and spalt like transcription factor 3 (SALL3), which are related to cancer.
|
31746370 |
2020 |
|
Liver carcinoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
These results indicated that promoter CpG island hypermethylation contributes to the downregulation of sall3 mRNA transcription in HCC.
|
22690083 |
2012 |
|
Malignant Neoplasms
|
0.020 |
PosttranslationalModification
|
group |
BEFREE |
This functional characterization of SALL3 sheds light on regulatory mechanisms for DNMT3A and provides new strategies to inhibit aberrant methylation in cancer.
|
19139273 |
2009 |
|
Primary malignant neoplasm
|
0.020 |
PosttranslationalModification
|
group |
BEFREE |
This functional characterization of SALL3 sheds light on regulatory mechanisms for DNMT3A and provides new strategies to inhibit aberrant methylation in cancer.
|
19139273 |
2009 |
|
Liver carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
We also show that SALL3 is inducible by BMP-4 and silenced by associated DNA methylation in hepatocellular carcinoma (HCC).
|
19139273 |
2009 |
|
Thymoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
No significant differences were observed in the promoter methylation of GNG4, HOXD9, or SALL3 between thymoma and the thymus.
|
31746370 |
2020 |
|
Thymic Carcinoma
|
0.010 |
PosttranslationalModification
|
disease |
BEFREE |
DNA methylation of GHSR, GNG4, HOXD9 and SALL3 is a common epigenetic alteration in thymic carcinoma.
|
31746370 |
2020 |
|
Congenital contractural arachnodactyly
|
0.010 |
Biomarker
|
disease |
BEFREE |
The results obtained in the current study suggested that spalt like transcription factor 3 and OPCML intronic transcript 1 may serve an important role in the development and progression of CCA.
|
31612038 |
2019 |
|
Chordoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Immunohistochemistry revealed LMX1A to be dominant in skull base chordoma, SALL3 to be unique to spine chordoma, and T to be common to both chordoma subtypes.
|
28844110 |
2018 |
|
Pelvic Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
Hypermethylated gene promoters were significantly more prevalent in renal pelvic tumors (p < 0.001), specifically for TMEFF2, GDF15, RASSF1A, SALL3 and ABCC6 (all p < 0.05).
|
29587736 |
2018 |
|
Alcoholic Intoxication, Chronic
|
0.010 |
Biomarker
|
disease |
BEFREE |
Chloroprene and valproic acid were identified as the expression regulators for genes C11orf66 and SALL3 which were captured by alcoholism SNPs, respectively.
|
28000566 |
2017 |
|
Malignant tumor of cervix
|
0.010 |
PosttranslationalModification
|
disease |
BEFREE |
Methylation of the SALL3 promoter was observed in 15 of 23 (65.21%) cervical cancer tissue samples, 15 of 23 (65.21%) matched pericarcinomatous tissue samples and 5 of 17 (29.41%) normal cervical tissue samples (p<0.05).
|
26697877 |
2015 |
|
Neoplasms
|
0.010 |
PosttranslationalModification
|
group |
BEFREE |
The aberrant hypermethylation of SALL3 together with HPV involvement inactivated its function as a tumor suppressor and contributed to carcinogenesis in cervical cancer.
|
26697877 |
2015 |
|
Cervix carcinoma
|
0.010 |
PosttranslationalModification
|
disease |
BEFREE |
Methylation of the SALL3 promoter was observed in 15 of 23 (65.21%) cervical cancer tissue samples, 15 of 23 (65.21%) matched pericarcinomatous tissue samples and 5 of 17 (29.41%) normal cervical tissue samples (p<0.05).
|
26697877 |
2015 |