|
Schizophrenia
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Genomic structure and localisation within a linkage hotspot of Disrupted In Schizophrenia 1, a gene disrupted by a translocation segregating with schizophrenia.
|
11317219 |
2001 |
|
Schizophrenia
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Using patients from a pedigree in which schizophrenia, depression or bipolar disorder have been linked with a balanced translocation at 1 and 11, candidate pathogenetic genes were cloned as DISC1 (disrupted in schizophrenia-1) and DISC2.
|
11377748 |
2001 |
|
Schizophrenia
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The results of karyotypic, clinical, and ERP investigations of this family suggest that the recently described genes DISC1 and DISC2, which are directly disrupted by the breakpoint on chromosome 1, may have a role in the development of a disease phenotype that includes schizophrenia as well as unipolar and bipolar affective disorders.
|
11443544 |
2001 |
|
Schizophrenia
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Interestingly, the strongest evidence for linkage in the combined study sample was obtained for marker D1S2709, which is an intragenic marker of the DISC1 gene, previously suggested as a susceptibility gene for schizophrenia.
|
11468279 |
2001 |
|
Schizophrenia
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We have undertaken a search for polymorphic sequence variation within Disrupted in Schizophrenia 1 and Disrupted in Schizophrenia 2 (DISC1 and DISC2), which are both novel genes that span a translocation breakpoint strongly associated with schizophrenia and related psychoses in a large Scottish family.
|
11525420 |
2001 |
|
Schizophrenia
|
0.600 |
Biomarker
|
disease |
BEFREE |
Given that many of these regions have been implicated in schizophrenia pathogenesis, these results suggest brain circuits through which DISC1 truncation may predispose to schizophrenia.
|
12802181 |
2003 |
|
Schizophrenia
|
0.600 |
Biomarker
|
disease |
BEFREE |
Based on these data, we propose that DISC1 is a multifunctional protein whose truncation contributes to schizophrenia susceptibility by disrupting intracellular transport, neurite architecture and/or neuronal migration, all of which have been hypothesized to be pathogenic in the schizophrenic brain.
|
12812986 |
2003 |
|
Schizophrenia
|
0.600 |
Biomarker
|
disease |
BEFREE |
Disrupted-In-Schizophrenia 1, a candidate gene for schizophrenia, participates in neurite outgrowth.
|
12874605 |
2003 |
|
Schizophrenia
|
0.600 |
Biomarker
|
disease |
BEFREE |
Our findings would also encourage more detailed analyses of the effect of DISC1 on the component-traits of schizophrenia.
|
14532331 |
2003 |
|
Schizophrenia
|
0.600 |
Biomarker
|
disease |
LHGDN |
In this study we genotyped 28 single nucleotide polymorphisms (SNPs) from 1q42 covering the three candidate genes TRAX, DISC1 and DISC2, using a study sample of 458 Finnish families ascertained for schizophrenia.
|
14532331 |
2003 |
|
Schizophrenia
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Nudel has been implicated to play a role in neuronal migration, together with the developmental variation in the abundance of the DISC1-Nudel complex, may implicate a defective DISC1-Nudel complex as a neurodevelopmental cause of schizophrenia.
|
14962739 |
2004 |
|
Schizophrenia
|
0.600 |
Biomarker
|
disease |
BEFREE |
Although the subcellular targeting of DISC1 is clearly complex, the association with mitochondria is of interest as many mitochondrial deficits have been reported in schizophrenia and other neuropsychiatric illnesses.
|
15121183 |
2004 |
|
Schizophrenia
|
0.600 |
GeneticVariation
|
disease |
LHGDN |
The gene named DISC1, disrupted at the chromosome 1 breakpoint, is a novel candidate gene that may have a role in the pathogenesis of schizophrenia.
|
15184103 |
2004 |
|
Schizophrenia
|
0.600 |
Biomarker
|
disease |
BEFREE |
The gene named DISC1, disrupted at the chromosome 1 breakpoint, is a novel candidate gene that may have a role in the pathogenesis of schizophrenia.
|
15184103 |
2004 |
|
Schizophrenia
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Our group has previously observed linkage on chromosome 1q42, maximizing within the DISC1 gene, which has also been implied in the etiology of schizophrenia based on functional studies.
|
15197400 |
2004 |
|
Schizophrenia
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Multipoint variance components linkage gave a maximum LOD of 2.77 (overall maximum LOD 2.47 after correction for multiple tests), 12 cM from the previously identified SCZ susceptibility locus DISC1.
|
15249933 |
2004 |
|
Schizophrenia
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
These results suggest that the genomic interval of DISC1 probably involved in transcriptional regulation does not display major genetic relevance in Japanese schizophrenia patients.
|
15342131 |
2004 |
|
Schizophrenia
|
0.600 |
Biomarker
|
disease |
BEFREE |
More recently, DISC1 was linked to schizophrenia, broadly defined, in the general Finnish population, through the undertransmission to affected women of a common haplotype from the region of intron 1/exon 2.
|
15386212 |
2004 |
|
Schizophrenia
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Additionally, a number of independent genetic studies highlight the region of chromosome 1q containing DISC1 and DISC2 as a likely susceptibility locus for both schizophrenia and affective disorders.
|
15478311 |
2004 |
|
Schizophrenia
|
0.600 |
Biomarker
|
disease |
BEFREE |
A modest association between FEZ1 and schizophrenia suggests that this gene and the DISC1-mediated molecular pathway might play roles in the development of schizophrenia, with FEZ1 affecting only a small subset of Japanese schizophrenia patients.
|
15522253 |
2004 |
|
Schizophrenia
|
0.600 |
Biomarker
|
disease |
BEFREE |
Current evidence supports NRG1, DTNBP1, DISC1, DAOA(G72), DAO, and RGS4 as schizophrenia susceptibility loci.
|
15744031 |
2005 |
|
Schizophrenia
|
0.600 |
Biomarker
|
disease |
BEFREE |
This result provides further supporting evidence for DISC1 as a susceptibility factor for both bipolar disorder and schizophrenia, consistent with the diagnoses in the original Scottish translocation family.
|
15838535 |
2005 |
|
Schizophrenia
|
0.600 |
Biomarker
|
disease |
LHGDN |
This result provides further supporting evidence for DISC1 as a susceptibility factor for both bipolar disorder and schizophrenia, consistent with the diagnoses in the original Scottish translocation family.
|
15838535 |
2005 |
|
Schizophrenia
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
These convergent data suggest that allelic variation within DISC1, either at Ser704Cys or haplotypes monitored by it, increases the risk for schizophrenia and that the mechanism of this effect involves structural and functional alterations in the hippocampal formation.
|
15939883 |
2005 |
|
Schizophrenia
|
0.600 |
GeneticVariation
|
disease |
LHGDN |
These convergent data suggest that allelic variation within DISC1, either at Ser704Cys or haplotypes monitored by it, increases the risk for schizophrenia and that the mechanism of this effect involves structural and functional alterations in the hippocampal formation.
|
15939883 |
2005 |