DISC1, DISC1 scaffold protein, 27185

N. diseases: 136; N. variants: 44
Disease: Schizophrenia ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.600 GeneticVariation disease LHGDN Based on the genetic and functional evidence that DISC1 may be associated with schizophrenia, we sequenced portions of DISC1 in 28 unrelated probands with schizophrenia and six unrelated probands with schizoaffective disorder, ascertained as part of a large sibpair study. 15940305 2005
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.600 Biomarker disease BEFREE Based on the genetic and functional evidence that DISC1 may be associated with schizophrenia, we sequenced portions of DISC1 in 28 unrelated probands with schizophrenia and six unrelated probands with schizoaffective disorder, ascertained as part of a large sibpair study. 15940305 2005
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.600 GeneticVariation disease BEFREE We studied association of the DISC1 and TRAX genes with schizophrenia in 338 Japanese by analyzing 15 single nucleotide polymorphisms (SNPs), including 12 SNPs in DISC1 and three in TRAX, respectively. 16039834 2005
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.600 AlteredExpression disease BEFREE DISC1 is expressed in the hippocampus and has been identified as a possible genetic risk factor for both schizophrenia and bipolar disorder. 16054297 2005
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.600 Biomarker disease BEFREE These data suggest that DISC1 is associated with neurocognitive functioning in schizophrenia. 16056147 2005
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.600 Biomarker disease LHGDN These data suggest that DISC1 is associated with neurocognitive functioning in schizophrenia. 16056147 2005
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.600 GeneticVariation disease BEFREE This finding should stimulate studies aiming at the molecular characterization of how the specific alleles of DISC1 affect the visual memory functions and eventually participates in the development of schizophrenia. 16103888 2005
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.600 Biomarker disease LHGDN This finding should stimulate studies aiming at the molecular characterization of how the specific alleles of DISC1 affect the visual memory functions and eventually participates in the development of schizophrenia. 16103888 2005
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.600 Biomarker disease BEFREE The DISC1 gene lies within 2.5 megabases of our peak marker on chromosome 1q42 and has been previously implicated in schizophrenia, bipolar disorder, and, recently, schizoaffective disorder. 16203953 2005
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.600 Biomarker disease BEFREE Several independent studies have identified Disrupted In Schizophrenia 1 (DISC1) as a potential susceptibility factor in the pathogenesis of schizophrenia and severe recurrent major depression. 16209927 2005
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.600 GeneticVariation disease BEFREE Specific alleles of the DISC1 and TRAX genes on 1q42 appear to contribute to genetic risk for schizophrenia through disruptive effects on the structure and function of the prefrontal cortex, medial temporal lobe, and other brain regions. 16275808 2005
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.600 Biomarker disease BEFREE DISC1 and PDE4B are interacting genetic factors in schizophrenia that regulate cAMP signaling. 16293762 2005
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.600 Biomarker disease BEFREE For example, DISC1 and NRG1 may confer susceptibility to a form of illness with mixed features of schizophrenia and mania. 16319375 2006
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.600 GeneticVariation disease LHGDN This analysis further strengthens the candidacy of DISC1 as a risk factor for schizophrenia in the general population, and suggests that more intensive searching for causative variants is justified. 16389590 2006
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.600 Biomarker disease BEFREE This analysis further strengthens the candidacy of DISC1 as a risk factor for schizophrenia in the general population, and suggests that more intensive searching for causative variants is justified. 16389590 2006
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.600 Biomarker disease MGD Disc1 is mutated in the 129S6/SvEv strain and modulates working memory in mice. 16484369 2006
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.600 Biomarker disease BEFREE Although, many other DISC1 binding partners still need to be investigated, these data implicate genetically linked abnormalities in the DISC1 molecular pathway in the pathophysiology of schizophrenia. 16510495 2006
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.600 Biomarker disease BEFREE Our findings also would encourage further studies, particularly family-based association studies with larger samples, to analyze the association between DISC1 and schizophrenia. 16524593 2007
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.600 Biomarker disease BEFREE They also provide converging evidence that the chromosome 1q42 region is relevant to schizophrenia by demonstrating linkage and association of markers of the Transelin-Associated-Factor-X and Disrupted-In- Schizophrenia-1 genes with prefrontal cortical gray matter deficits in twins discordant for schizophrenia. 16595856 2006
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.600 Biomarker disease BEFREE Genes and schizophrenia: beyond schizophrenia: the role of DISC1 in major mental illness. 16699061 2006
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.600 Biomarker disease BEFREE On the basis of these findings, production of DISC1 genetically engineered mice is proposed as a promising animal model for SZ and BP. 16797264 2006
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.600 GeneticVariation disease BEFREE The original finding of DISC1 as a gene disrupted by a balanced translocation on chromosome 1q42 that segregates with schizophrenia, bipolar disorder, and recurrent major depression has sparked a number of confirmatory linkage and association studies. 16843095 2006
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.600 Biomarker disease BEFREE The DISC1 gene has been linked to schizophrenia in two independent Caucasian populations. 16936715 2007
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.600 Biomarker disease LHGDN Evidence that a DISC1 frame-shift deletion associated with psychosis in a single family may not be a pathogenic mutation. 16936759 2006
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.600 GeneticVariation disease BEFREE We therefore performed an association study of the DISC1 gene with MDD and schizophrenia. 16959794 2006