DISC1, DISC1 scaffold protein, 27185

N. diseases: 136; N. variants: 44
Disease: Behavior Disorders ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0004930
Disease: Behavior Disorders
Behavior Disorders 		0.020 Biomarker group BEFREE A transgenic rat overexpressing non-mutant human DISC1, modeling aberrant proteostasis of the DISC1 protein, displays behavioral, biochemical and anatomical deficits consistent with aspects of mental disorders, including changes in the dorsal striatum, an anatomical region critical in the development of behavioral disorders. 29467617 2018
CUI: C0004930
Disease: Behavior Disorders
Behavior Disorders 		0.020 Biomarker group BEFREE The PDE4 isoform PDE4B1 also interacts with the DISC1 protein, implicated in neural development and behavioral disorders. 29197324 2017