DISC1, DISC1 scaffold protein, 27185

N. diseases: 136; N. variants: 44
Disease: Impaired cognition ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0338656
Disease: Impaired cognition
Impaired cognition 		0.100 Biomarker disease BEFREE This concept was underpinned by the function of the molecule disrupted-in-schizophrenia 1 (DISC1), which represents an intracellular hub of developmental processes and has been related to cognitive dysfunction in psychiatric disorders. 30617212 2019
CUI: C0338656
Disease: Impaired cognition
Impaired cognition 		0.100 Biomarker disease BEFREE Voluntary exercise improves cognitive deficits in female dominant-negative DISC1 transgenic mouse model of neuropsychiatric disorders. 28593819 2019
CUI: C0338656
Disease: Impaired cognition
Impaired cognition 		0.100 AlteredExpression disease BEFREE Overexpression of DISC1 via adeno-associated virus (serotype 8, AAV8) in the hippocampus of 8-month-old APP/PS1 transgenic mice for 4 months rescues cognitive deficits, synaptic loss, and Aβ plaque accumulation, in a way dependent on the interaction of DISC1 with LC3. 30488644 2019
CUI: C0338656
Disease: Impaired cognition
Impaired cognition 		0.100 GeneticVariation disease BEFREE Intra-nasal dopamine alleviates cognitive deficits in tgDISC1 rats which overexpress the human DISC1 gene. 29107702 2017
CUI: C0338656
Disease: Impaired cognition
Impaired cognition 		0.100 Biomarker disease BEFREE These results indicate that DISC1 attenuates Aβ generation and cognitive deficits of APP/PS1 transgenic mice through promoting lysosomal degradation of BACE1. 26062786 2016
CUI: C0338656
Disease: Impaired cognition
Impaired cognition 		0.100 GeneticVariation disease BEFREE In conclusion, DISC1 gene variations may affect the course of cognitive deficits found in patients suffering from the first episode of non-affective psychosis. 26443054 2015
CUI: C0338656
Disease: Impaired cognition
Impaired cognition 		0.100 Biomarker disease BEFREE These findings indicate that truncations of Disc1 alter glutamatergic and GABAergic neurotransmission both commonly and differently in the models and some of the effects are sex-specific, revealing how altered Disc1 expression may contribute to behavioral disruptions and cognitive deficits of SZ. 23481583 2013
CUI: C0338656
Disease: Impaired cognition
Impaired cognition 		0.100 GeneticVariation disease BEFREE Association of distinct allelic haplotypes of DISC1 with psychotic and bipolar spectrum disorders and with underlying cognitive impairments. 17673452 2007
CUI: C0338656
Disease: Impaired cognition
Impaired cognition 		0.100 Biomarker disease BEFREE Disrupted in Schizophrenia 1 (DISC1) is a schizophrenia risk gene associated with cognitive deficits in both schizophrenics and the normal ageing population. 17043677 2007
CUI: C0338656
Disease: Impaired cognition
Impaired cognition 		0.100 Biomarker disease BEFREE Thus, DISC1 and its pathways support the neurodevelopmental hypothesis of schizophrenia and provide a mechanistic explanation for the characteristic cognitive deficits. 17258902 2007
CUI: C0338656
Disease: Impaired cognition
Impaired cognition 		0.100 Biomarker disease BEFREE After reviewing principles important for the selection of genes, neuroimaging techniques, and subjects, we describe how imaging-genetics investigations have helped clarify the contribution of five candidate genes (COMT, GRM3, G72, DISC1, and BDNF) to cognitive deficits in schizophrenia. 16603474 2006