|
Nonorganic psychosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Thus, the utility of DISC1 as a biological lead for psychosis research is clear.
|
31204062 |
2019 |
|
Nonorganic psychosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
This could be a potential mechanism mediating risk for psychosis, lending further credibility to the fact that DISC1 is of functional interest in the aetiology of major mental illness.
|
29945223 |
2018 |
|
Nonorganic psychosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Variations in Disrupted-in-Schizophrenia 1 gene modulate long-term longitudinal differences in cortical thickness in patients with a first-episode of psychosis.
|
26209938 |
2016 |
|
Nonorganic psychosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
These findings overlap with those shown in affected patients with psychosis and in DISC1 animal models and highlight the value of rare but biologically informative mutations in modeling psychosis.
|
26102360 |
2015 |
|
Nonorganic psychosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We demonstrate that PAK7 is developmentally co-expressed with another known psychosis risk gene (DISC1) suggesting a potential molecular mechanism involving aberrant synapse development and plasticity.
|
24474471 |
2014 |
|
Nonorganic psychosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Effect of DISC1 on the P300 waveform in psychosis.
|
21878470 |
2013 |
|
Nonorganic psychosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
We used genome-wide genotyping data for a Norwegian sample of healthy controls (n = 171) and patients with a history of psychosis (n = 184), to investigate 61 SNPs in the DISC1 region for putative association with structural magnetic resonance imaging (sMRI) measures (hippocampal volume; mean cortical thickness; and total surface area, as well as cortical thickness and area divided into four lobar measures).
|
22815203 |
2012 |
|
Nonorganic psychosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
By conditioning a previous genome-wide association study on DISC1, we have been able to identify eight genes as associating to psychosis proneness.
|
22363459 |
2012 |
|
Nonorganic psychosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
DISC1, a promising candidate susceptibility gene, encodes a protein which interacts with many other proteins, including CIT, NDEL1, NDE1, FEZ1 and PAFAH1B1, some of which also have been associated with psychosis.
|
20084519 |
2010 |
|
Nonorganic psychosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The balanced t(1;11)(q42.1;q14.3) translocation with a breakpoint between exons 8 and 9 of DISC1 has been found to be co-segregated with psychosis in a Scottish family.
|
19586833 |
2009 |
|
Nonorganic psychosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
To study the effect of previously identified risk alleles of DISC1 on quantitative intermediate phenotypes for psychosis in an unselected population.
|
19188535 |
2009 |
|
Nonorganic psychosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
No pathogenic rearrangement within the DISC 1 gene in psychosis.
|
18395819 |
2009 |
|
Nonorganic psychosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Because the DISC1 gene is shown to be a causative gene for psychosis in a Scottish family, the FEZ1 gene may well have importance in mental disease.
|
17374448 |
2007 |
|
Nonorganic psychosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Candidate gene association studies have provided further evidence to suggest that some genes including two of the most studied candidates, Disrupted in Schizophrenia 1 (DISC1) and Neuregulin 1 (NRG1) may be involved in both types of psychosis.
|
17449450 |
2007 |
|
Nonorganic psychosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The genetics and biology of DISC1--an emerging role in psychosis and cognition.
|
16843095 |
2006 |