DISC1, DISC1 scaffold protein, 27185

N. diseases: 136; N. variants: 44
Disease: Decreased Concentration ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C3899403
Disease: Decreased Concentration
Decreased Concentration 		0.010 AlteredExpression phenotype BEFREE We report that late adolescent stress in combination with Disrupted-in-Schizophrenia 1 (DISC1) genetic risk elicited alterations in glutamatergic neurons in the PFc, such as increased expression of glutamate transporters, decreased extracellular levels of glutamate, decreased concentration of d-serine, and impaired activation of NMDA-Ca<sup>2+</sup>/calmodulin kinase II signaling. 28756461 2017